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Basic study of new treatments for lymphedema by application of endovascular treatment

Research Project

Project/Area Number 18K09487
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56070:Plastic and reconstructive surgery-related
Research InstitutionYokohama City University

Principal Investigator

MAEGAWA Jiro  横浜市立大学, 医学研究科, 教授 (70244449)

Co-Investigator(Kenkyū-buntansha) 矢吹 雄一郎  横浜市立大学, 附属病院, 助教 (30610357)
三上 太郎  横浜市立大学, 医学研究科, 客員准教授 (90315804)
小林 眞司  地方独立行政法人神奈川県立病院機構神奈川県立こども医療センター(臨床研究所), 臨床研究所, 部長 (90464536)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsリンパ浮腫 / 血管内治療 / ワイヤ / ガイドワイヤ / リンパ管静脈吻合
Outline of Final Research Achievements

As a basic study of new treatments for lymphedema by application of endovascular treatment, we developed a thin wire which can be inserted into lymphatic vessels. The wire with its outer diameter of 0.25 mm can be detectable by ultrasound sonography and X-ray. As a preclinical study, we evaluated safety, effectiveness, and possibility for endovascular treatment of the wire using pig. As a result, no abnormal changes and signs in lymphatic endothelium and valves were observed. It was easy to detect the wire by X-ray. In addition, we made lymphaticovenous anastomosis, then the wire could be inserted into the lymphatic vessels and pass the anastomosis, which suggested possibilities in applications of endovascular treatment in lymphedema.

Academic Significance and Societal Importance of the Research Achievements

リンパ機能障害を主原因とするリンパ浮腫の診断はリンパシンチや蛍光リンパ造影など画像診断が中心であるが、リンパ機能障害によるリンパ管の狭窄や閉塞部位を直接診断する方法はなかった。本研究成果により、リンパ管ワイヤを用いて障害部位を診断することが可能となった。さらに動静脈における血管内治療をリンパ浮腫治療に応用できる可能性が示唆され、低侵襲な新たなリンパ浮腫治療の可能性が広がった。得られた結果を基に、本ワイヤによるリンパ管障害部位の診断の臨床応用を目指した結果、本年度末に医療機器としての承認を得ることができ、ワイヤの上市がなされた。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (15 results)

All 2022 2021 2020 2019 2018

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results)

  • [Journal Article] A phase III, multicenter, single-arm study to assess the utility of indocyanine green fluorescent lymphography in the treatment of secondary lymphedema.2022

    • Author(s)
      Akita S, Unno N, Maegawa J, Kimata Y, Fukamizu H, Yabuki Y, Kitayama S, Shinaoka A, Yamada K, Sano M, Ota Y, Ohnishi F, Sakuma H, Nuri T, Ozawa Y, Shiko Y, Kawasaki Y, Hanawa M, Fujii Y, Imanishi E, Fujiwara T, Hanaoka H, Mitsukawa N.
    • Journal Title

      Vasc Surg Venous Lymphat Disord

      Volume: 10 Issue: 3 Pages: 728-737

    • DOI

      10.1016/j.jvsv.2021.09.006

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Novel Approach to Subcutaneous Collecting Lymph Ducts Using a Small Diameter Wire in Animal Experiments and Clinical Trials2021

    • Author(s)
      Yuichiro Yabuki , Jiro Maegawa , Naohiko Shibukawa , Shintaro Kagimoto , Shinya Kitayama , Shinobu Matsubara , Taro Mikami
    • Journal Title

      Lympat Res Biol.

      Volume: 19 Issue: 1 Pages: 73-79

    • DOI

      10.1089/lrb.2019.0047

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preliminary Report: The Relevance of Tumor Necrosis Factor-α in Acquired Primary Lymphedema?A Histopathological Investigation2019

    • Author(s)
      Asano Saori、Mikami Taro、Matsubara Shinobu、Maegawa Jiro、Wakui Hiromichi、Tamura Kouichi、Yoshimi Ryusuke
    • Journal Title

      Lymphatic Research and Biology

      Volume: 未定 Issue: 3 Pages: 232-238

    • DOI

      10.1089/lrb.2019.0046

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] リンパ管静脈吻合術の今後2019

    • Author(s)
      前川二郎, 北山 晋也, 鍵本 慎太郎, 矢吹 雄一郎
    • Journal Title

      リンパ学

      Volume: 42 Pages: 32-35

    • Related Report
      2019 Research-status Report
  • [Journal Article] 慢性リンパ浮腫患者の反復性蜂窩織炎に対する抗菌薬の長期低用量内服の有効性2019

    • Author(s)
      角田佑衣、矢吹雄一郎、足立英子、鍵本慎太郎、北山晋也、三上太郎、佐武利彦、前川二郎
    • Journal Title

      形成外科

      Volume: 62 Pages: 1009-1016

    • NAID

      40022013449

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] リンパ浮腫2019

    • Author(s)
      矢吹雄一郎、前川二郎
    • Journal Title

      形成外科

      Volume: 62

    • Related Report
      2019 Research-status Report
  • [Journal Article] リンパ浮腫診断と治療up-to-date2019

    • Author(s)
      前川二郎, 北山 晋也, 矢吹 雄一郎, 平出 さおり, 三上 太郎
    • Journal Title

      リンパ学

      Volume: 42 Pages: 57-59

    • Related Report
      2019 Research-status Report
  • [Presentation] Methods for detection of lymphatic vessels in lymphaticovenous anastomosis2021

    • Author(s)
      Jiro Maegawa
    • Organizer
      The 5th Congress of Asian Pacific Federation of Societies for Reconstructive Microsurgery
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] リンパ浮腫診療におけるマイクロサージャリー -手技の成功と治療結果の解離-2021

    • Author(s)
      前川二郎
    • Organizer
      第48回日本マイクロサージャリー学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] リンパ浮腫に対するリンパシンチグラフィにおける撮影条件の標準化に向けて2020

    • Author(s)
      矢吹雄一郎、小池智之、足立英子、北山晋也、前川二郎
    • Organizer
      第44回リンパ学会
    • Related Report
      2020 Research-status Report
  • [Presentation] リンパ管静脈側端吻合術の吻合部長期開存に関する検討2020

    • Author(s)
      矢吹雄一郎、足立英子、北山晋也、前川二郎
    • Organizer
      第47回マイクロサージャリー学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Development of lymphatic wire for detection of lymph collectors in treatment of peripheral lymphedema2019

    • Author(s)
      Jiro Maegawa
    • Organizer
      The 9th International Lymphoedema Framework Conference (Chicago, USA)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] リンパ浮腫 診断と治療up to date2019

    • Author(s)
      前川二郎
    • Organizer
      第43回日本リンパ学会(東京)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] リンパ管静脈吻合術の今後2018

    • Author(s)
      前川二郎
    • Organizer
      第42回日本リンパ学会(弘前)
    • Related Report
      2018 Research-status Report
  • [Presentation] SPECT-CT lymphoscintigraphy for surgical treatment in peripheral lymphedema2018

    • Author(s)
      Jiro Maegawa
    • Organizer
      8th International Lymphedema Framework(Rotterdam, Netherlands)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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