In situ regenerative treatment for long peripheral nerve defect with hybrid type artificial nerve
| Project/Area Number |
18K09491
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
林 礼人 順天堂大学, 医学部, 教授 (10365645)
丸山 祐一郎 順天堂大学, 大学院医学研究科, 教授 (80181840)
原 章 順天堂大学, 医学部, 准教授 (50327839)
吉澤 秀和 順天堂大学, 医学部, 非常勤助教 (10512593)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 人工神経 / 生体内再生治療 / 端側神経縫合 / 遺伝子改変マウス / シュワン細胞 / 末梢神経再生 / ハイブリッド型人工神経 / 端側吻合 |
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| Outline of Final Research Achievements |
End to side (ETS) neurorrhaphy has been used as an option for an axonal provider. In this study, we investigated whether ETS neurorrhaphy could be a useful technique as a Schwann cell (SCs) provider in Artificial Nerve (AN) in vivo. The sciatic nerve with axon fluorescent of 8-12 weeks Thy1-GFP rats were used for this study. From our in vivo study, End to Side neurorrhaphy, which is used as a axonal provider, could be useful as a Schwann cell provider to support axonal elongation in Artificial nerve.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで四肢外傷よる神経損傷や悪性腫瘍切除後に生じた長い神経欠損に対して、自家神経移植術が標準術式として用いられてきたが、移植神経採取部の合併症、採取可能な神経長の限界などの問題点がある。2013年3月から人工神経の臨床応用が可能となったが、現時点での人工神経の適応は、神経欠損長が3㎝以内で感覚神経のみに限られている。本研究の結果により、長い神経欠損を架橋する際に、軸索伸長を促進するための栄養因子を供給するシュワン細胞の人工神経内への導入が生体内で可能となった。
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Report
(5 results)
Research Products
(63 results)
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[Journal Article] COVID-19: Initial experience of an international group of hand surgeons.2020
Author(s)
Ducournau F, Arianni M, Awwad S, Baur EM, Beaulieu JY, Bouloudhnine M, Caloia M, Chagar K, Chen Z, Chin AY, Chow EC, Cobb T, David Y, Delgado PJ, Woon Man Fok M, French R, Golubev I, Haugstvedt JR, Ichihara S.
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Journal Title
Hand Surgery and Rehabilitations
Volume: 39
Issue: 3
Pages: 159-166
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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