| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
This study demonstrated that (1) sweet-sensitive taste cells (T1R3-expressing taste cells) possess leptin signaling components (STAT3, SHP2, PI3K), (2) among these components, PI3K plays a critical role in suppression of sweet responses of taste cells by leptin, and (3) leptin-induced activation of PI3K leads to production of PIP3 and phosphorylation of Akt in T1R3-expressing taste cells.
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