• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functions of Rho family proteins on hard tissue formation

Research Project

Project/Area Number 18K09512
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57010:Oral biological science-related
Research InstitutionShowa University

Principal Investigator

Yamada Atsushi  昭和大学, 歯学部, 講師 (50407558)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordssignal transduction / 骨軟骨代謝 / 細胞内シグナル伝達
Outline of Final Research Achievements

The low molecular weight Rho family G proteins Rac1 and Cdc42 serve as molecular switches that transmit various extracellular information into the cell. Regarding cells, it is known that various biological activities, such as cell proliferation, differentiation, and cell death, are regulated mainly through the regulation of actin cytoskeleton. The purpose of this study was to study the functions of Rac1 and Cdc42 genes in hard tissue cells using various inhibitors and activators.

Academic Significance and Societal Importance of the Research Achievements

Rhoファミリー低分子量Gタンパク質は生体内で様々な機能を有することが細胞レベルおよび生体レベルで知られている。そのため、Rhoファミリー低分子量Gタンパク質中でもRac1およびCdc42の硬組織細胞における機能に関する研究は本研究分野で非常に社会的意義が大きいと考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (26 results)

All 2021 2020 2019 2018 Other

All Journal Article (12 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 11 results,  Open Access: 8 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Zoledronate promotes inflammatory cytokine expression in human CD14-positive monocytes among peripheral mononuclear cells in the presence of γδ T cells.2021

    • Author(s)
      Takimoto R, Suzawa T, Yamada A, Sasa K, Miyamoto Y, Yoshimura K, Sasama Y, Tanaka M, Kinoshita M, Ikezaki K, Ichikawa M, Yamamoto M, Shirota T, Kamijo R
    • Journal Title

      Immunology

      Volume: 162(3) Issue: 3 Pages: 306-313

    • DOI

      10.1111/imm.13283

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells in Uremic Rats.2020

    • Author(s)
      Kato T, Mizobuchi M, Sasa K, Yamada A, Ogata H, Honda H, Sakashita A, Kamijo R
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 532(1) Issue: 1 Pages: 11-18

    • DOI

      10.1016/j.bbrc.2020.05.096

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional analysis of PTH1R variants found in primary failure of eruption.2020

    • Author(s)
      Izumida E, Suzawa T, Miyamoto Y, Yamada A, Takimoto R, Otsu M, Saito T, Yamaguchi T, Nishimura K, Ohtaka M, Nakanishi M, Yoshimura K, Sasa K, Takimoto R, Uyama R, Shirota T, Maki K, Kamijo R.
    • Journal Title

      Journal of Dental Research

      Volume: 99 Issue: 4 Pages: 429-436

    • DOI

      10.1177/0022034520901731

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ネフロネクチンの骨代謝における機能.2020

    • Author(s)
      山田篤,木下三博,上條竜太郎
    • Journal Title

      月刊「BIO Clinica」

      Volume: 35(7) Pages: 48-52

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Lipopolysaccharide (LPS) Inhibits Ectopic Bone Formation Induced by Bone Morphogenetic Protein-2 and TGF-β1 through IL-1β Production.2020

    • Author(s)
      Matsumoto A, Takami M, Urano E, Nakamachi T, Yoshimura K, YamadaA, Suzawa T, Miyamoto Y, Baba K, Kamijo R.
    • Journal Title

      Journal of Oral Biosciences

      Volume: 62 Issue: 1 Pages: 44-51

    • DOI

      10.1016/j.job.2020.01.004

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Visualization of junctional epithelial cell replacement by oral gingival epithelial cells over a life time and after gingivectomy.2019

    • Author(s)
      Kato M, Tanaka J, Aizawa R, Yajima-Himuro S, Seki T, Tanaka K, Yamada A, Ogawa M, Kamijo R, Tsuji T, Mishima K, Yamamoto M
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 7640-7640

    • DOI

      10.1038/s41598-019-44065-x

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cdc42 regulates cranial suture morphogenesis and ossification2019

    • Author(s)
      Aizawa Ryo、Yamada Atsushi、Seki Tatsuaki、Tanaka Junichi、Nagahama Ryo、Ikehata Mikiko、Kato Tadashi、Sakashita Akiko、Ogata Hiroaki、Chikazu Daichi、Maki Koutaro、Mishima Kenji、Yamamoto Matsuo、Kamijo Ryutaro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 512 Issue: 2 Pages: 145-149

    • DOI

      10.1016/j.bbrc.2019.02.106

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunotherapy for malignant tumors with focus on toll-like receptors.2019

    • Author(s)
      Manome Y, Suzuki D, Nishida R, Yamada A, Miyamoto Y, Funatsu T, Kamijo R
    • Journal Title

      Oral Sci Int

      Volume: 16 Issue: 1 Pages: 3-7

    • DOI

      10.1002/osi2.1011

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 血管形成におけるCdc42の役割2019

    • Author(s)
      吉田優子、山田篤、吉村健太郎、上條竜太郎、飯島毅彦
    • Journal Title

      日本口腔組織培養学会

      Volume: 28 Pages: 1-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nephronectin Expression is Inhibited by Inorganic Phosphate in Osteoblasts2018

    • Author(s)
      Kato Tadashi、Yamada Atsushi、Sasa Kiyohito、Yoshimura Kentaro、Morimura Naoko、Ogata Hiroaki、Sakashita Akiko、Kamijo Ryutaro
    • Journal Title

      Calcified Tissue International

      Volume: 104 Issue: 2 Pages: 201-206

    • DOI

      10.1007/s00223-018-0484-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation.2018

    • Author(s)
      Sasa K, Yoshimura K, Yamada A, Suzuki D, Miyamoto Y, Imai H, Nagayama K, Maki K, Yamamoto M, Kamijo R
    • Journal Title

      Sci. Rep.

      Volume: 8(1) Issue: 1 Pages: 10579-10579

    • DOI

      10.1038/s41598-018-28605-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cooperation of Rho family proteins Rac1 and Cdc42 in cartilage development and calcified tissue formation2018

    • Author(s)
      Ikehata M, Yamada A, Fujita K, Yoshida Y, Kato T, Sakashita A, Ogata H, Iijima T, Kuroda M, Chikazu D, Kamijo R.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 印刷中 Issue: 3 Pages: 525-529

    • DOI

      10.1016/j.bbrc.2018.04.032

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 骨芽細胞においてPMAはNephronectinの発現をPKCαおよびδを介し抑制する.2020

    • Author(s)
      木下三博、山田篤、上條竜太郎
    • Organizer
      第38回 日本骨代謝学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 抗MHC抗体投与後の肺水腫における血管内皮グリコカリックスの分解.2020

    • Author(s)
      西田梨恵,鈴木 大,笹 清人,山田 篤,田中準一,三島健二,飯島毅彦,上條竜太郎
    • Organizer
      第62回 歯科基礎医学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ゾレドロン酸による末梢血単球の破骨細胞分化抑制.2020

    • Author(s)
      瀧本玲子,田中元博,山田 篤,宮本洋一,笹 清人,須澤徹夫,吉村健太郎,高見正道,代田達夫,上條竜太郎
    • Organizer
      第62回 歯科基礎医学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Rhoファミリー低分子量Gタンパク質Cdc42の血管形成および骨形成に対する機能解析.2020

    • Author(s)
      吉田優子, 山田篤, 鈴木航, 上條竜太郎, 飯島毅彦
    • Organizer
      第62回 歯科基礎医学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ゾレドロン酸による末梢血単球の破骨細胞分化抑制.2020

    • Author(s)
      瀧本玲子,笹 清人,山田 篤,宮本洋一,吉村健太郎,代田達夫,上條竜太郎
    • Organizer
      第38回 日本骨代謝学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Gelated ozone suppresses osteoclast differentiation and periodontal bone loss.2019

    • Author(s)
      Oshio A, Miyamoto Y, Sasa K, Yamada A, Yoshimura K, Kamijo R
    • Organizer
      第67回国際歯科研究学会日本部会総会・学術大会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 歯周病性骨破壊に対するオゾンジェルの効2019

    • Author(s)
      吉村健太郎、宮本洋一、笹清人、 山田篤、坂井信裕、高見正道、上條竜太郎
    • Organizer
      第2回 オゾン医療・審美学会総会・学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ビスホスホネートのヒト末梢血単核細胞に対する作用の解析2019

    • Author(s)
      瀧本 玲子、宮本 洋一、山田 篤、須澤 徹夫、笹 清人、上條 竜太郎、代田 達夫
    • Organizer
      第65回昭和大学学士会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] PMA による細胞外マトリックスタンパク質 Nephronectin の発現制御機構の解明2019

    • Author(s)
      木下三博、山田 篤、上條竜太郎
    • Organizer
      第56回 日本口腔組織培養学会学術大会・総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Cdc42は出生後の血管形成および血管を介した骨形成に重要な役割を果たしている。2018

    • Author(s)
      吉田優子、山田篤、上條竜太郎
    • Organizer
      第55回日本口腔組織培養学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 骨軟骨形成におけるRhoファミリー低分子量Gタンパク質Rac1とCdc42の機能解析2018

    • Author(s)
      池畑美紀子、山田篤、吉田優子、加藤憲、近津大地、上條竜太郎
    • Organizer
      第36回日本骨代謝学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Cdc42は出生後の血管形成および血管を介した骨形成に重要な役割を果たしている。2018

    • Author(s)
      吉田優子、山田篤、池畑美紀子、加藤憲、上條竜太郎
    • Organizer
      第36回日本骨代謝学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 細胞外リン濃度の上昇はFGFシグナルを介し、細胞外マトリックスタンパク質Nephronectinの発現を抑制する。2018

    • Author(s)
      加藤憲、山田篤、吉田優子、池畑美紀子、緒方浩顕、上條竜太郎
    • Organizer
      第36回日本骨代謝学会学術集会
    • Related Report
      2018 Research-status Report
  • [Remarks] 昭和大学歯学部 口腔生化学講座

    • URL

      http://www10.showa-u.ac.jp/~oralbio/index.html

    • Related Report
      2019 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi