| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Bones' shape and mechanical strength are maintained through bone remodeling composed of bone resorption by osteoclasts and bone formation by osteoblasts. The roles of nitric oxide (NO) and reactive oxygen species (ROS) in bone remodeling have not been fully clarified. In this study, we examined the production and function of 8-nitro-cGMP, a novel signaling molecule of NO and ROS, in osteoclasts, osteoblasts, and osteocytes. All the three types of cells examined produced 8-nitro-cGMP. 8-nitro-cGMP promoted osteoclast differentiation and suppressed mineralization by osteoblasts. These results indicate that 8-nitro-cGMP is a regulator that supports bone resorption and suppresses bone formation.
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