| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The investigation for bone diseases was developed mainly via suppression of bone resorption including RANKL intracellular signaling. However, the application for OPG which is a RANKL-decoy receptor are not well examined. In osteoblasts expressing RANKL-venus or OPG-cherry, long-term stretch-mechanical stimulus induced the distinct intracellular transportation. Long-term light stimulus which induces the changes in membrane potential promoted the intracellular transportation of OPG but not RANKL, suggesting that specific condition of light stimulus or mechanical stimulus would occur the distinct intracellular transportation of OPG.
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