| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Uncarboxylated osteocalcin (GluOC) is a bone-derived hormone that plays an important role not only in glucose and energy metabolism but also in maintaining skeletal muscle mass. GPRC6A, a member of family C of G protein-coupled receptors, has been reported to serve as a GluOC receptor. We analyzed adipocyte-specific GPRC6A deficient mice and found that these animals manifested adipocyte hypertrophy under obesogenic environment. This was associated with reduced lipolytic activity due to down-regulation of lipolytic enzymes in adipose tissue of the knockout mice. Suppressed lipolysis resulted in reduced fatty acid release in the circulation compared with control mice. Our results suggest that the constitutive activation of GPRC6A signaling by GluOC in adipocytes plays a key role in lipolysis, providing fatty acid as an energy source to the skeletal muscle.
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