Elucidation of sleep bruxism mechanism using chemogenetic analysis of neural circuit assembly
| Project/Area Number |
18K09527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57010:Oral biological science-related
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
井上 富雄 昭和大学, 歯学部, 教授 (70184760)
船戸 弘正 筑波大学, 国際統合睡眠医科学研究機構, 客員教授 (90363118)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 睡眠時ブラキシズム / セロトニン / SSRI / うつ病 / 光遺伝学 / 薬理遺伝学 / ブラキシズム / Disc1 |
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| Outline of Final Research Achievements |
Bruxism is a multifactorial disease caused by involuntary masticatory muscle activities such as clenching and clenching, in which various factors such as stress and drug administration are involved in a complex manner. However, details regarding the related mechanism(s) remain largely unknown. We found that administration of a serotonin reuptake inhibitor (SSRI), a type of antidepressant known to induce bruxism, increased masseter muscle activity during non-REM sleep. Using that phenomenon as an index, the activity of GABA neurons present in ventrolateral periaqueductal gray matter (vlPAG) was altered by employing a DREADD system, though there was nearly no subsequent alteration in masseter muscle activity. These results suggest that vlPAG GABA neurons may not be involved in SSRI-induced masseter muscle activity.
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| Academic Significance and Societal Importance of the Research Achievements |
多くの国民が悩んでいる歯ぎしりや食いしばり（総称してブラキシズムと言う）の治療法を開発するために、ブラキシズムがどのようにして起こるのかメカニズムを探索している。私たちは、ブラキシズムの誘発因子の1つである抗うつ薬、セロトニン再取り込み阻害薬（SSRI）をマウスに投与し、ノンレム睡眠中の顎を動かす筋肉の活動性が上昇することを発見した。この現象は、中脳水道周囲灰白質腹外側部という脳の一部分に存在するGABAニューロンの活動状態を人為的に変化させても、ほとんど変化がなかった。このように、顎を動かす筋肉に脳のどの部分が影響しているのかを調べ、ブラキシズムの治療法の開発に役立てようと考えている。
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Report
(5 results)
Research Products
(40 results)
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[Presentation] 小細胞性網様体吻側領域に存在するPhox2b陽性ニューロンの電気生理学的・形態学的解析2021
Author(s)
梶原里紗,中村史朗,池田啓子,鬼丸洋,中山希世美,望月文子,壇辻昌典,西村晶子,立川哲史,飯島毅彦,井上富雄
Organizer
第68回昭和大学学士会総会
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[Presentation] Activation of 5-HT2A receptor enhances function of GluN2A-containing NMDA receptor via Src kinase in dendrites of rat jaw-closing motoneurons2018
Author(s)
Dantsuji M, Nakamura S, Mochizuki A, Nakayama K, Kiyomoto M, S. K. Park, Y. J. Bae, Ozeki M, Inoue T.
Organizer
Society for Neuroscience 48th annual meeting, San Diego, U.S.A.
Related Report
Int'l Joint Research
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[Presentation] 5-HT2A receptor mediates enhancement of NMDA receptor function via Src pathway in dendrites of jaw-closing motoneurons in rats2018
Author(s)
Dantsuji M, Nakamura S, Mochizuki A, Nakayama K, Kiyomoto M, S. K. Park, Y. J. Bae, Ozeki M, Inoue T.
Organizer
11th Forum of Neuroscience, Berlin, Germany.
Related Report
Int'l Joint Research
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