• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of intelligent drug-delivery systems controlled under external stimulation with NIR irradiation

Research Project

Project/Area Number 18K09616
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57040:Regenerative dentistry and dental engineering-related
Research InstitutionNagasaki University (2019-2022)
Hokkaido University (2018)

Principal Investigator

ABE Shigeaki  長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (40374566)

Co-Investigator(Kenkyū-buntansha) 高田 知哉  公立千歳科学技術大学, 理工学部, 准教授 (00342444)
兵野 篤  旭川工業高等専門学校, 物質化学工学科, 助教 (20554299)
木場 隆之  北見工業大学, 工学部, 准教授 (40567236)
玉井 美保  北海道大学, 歯学研究院, 助教 (20619704)
江良 裕子  埼玉県立大学, 保健医療福祉学部, 助教 (00825309)
成徳 英理  北海道大学, 歯学研究院, 学術研究員 (00829393)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords薬剤徐放 / ゾル-ゲル / 赤外照射 / 外部刺激 / ハイドロゲル / 非侵襲性 / 赤外応答性 / ゾルーゲル / 外部刺激応答 / 光熱変換 / インテリジェントDDS
Outline of Final Research Achievements

We have investigated a hydrogel composite that undergoes a sol-gel phase transition under external stimulation. Obtained polyacrylamide-based hydrogel composite showed a reversible sol-gel phase transition during the heating-cooling process. In order to use infrared light as an external stimulus for controlling the phase transition process, we prepared hydrophilic carbon nanotubes (CNT) derivatives with surface chemical modification because CNTs are known to have effective photothermal conversion properties. Then we prepared a composite material with hydrogel. made. The obtained material indicated efficiently sol transition by infrared light irradiation and exhibited a reversible sol-gel phase transition. Release of the model drug was also confirmed by the transition. Based on these results, we succeeded in prototyping a novel material that exhibits a sol-gel phase transition upon irradiation with infrared light and enables drug release.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果として得られた赤外光照射により薬剤徐放を可能とする新規ハイドロゲル複合材料は、薬剤の投与を必要とするタイミングに、開腹などの外科的な侵襲を与えず、且つ大型の装置の使用を必要とせずに、小型の赤外光源を用いることで簡便に薬剤の放出を可能とする材料である。用いた材料は既に医療材料として使用されている化合物や、安全性の検討がなされている物質であり、医療応用への展開も期待できる。この技術により、歯科のみならず医学領域においても、非侵襲的に効果的な薬剤の投与を可能とするため、患者のQOLの向上への貢献が期待される。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (46 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (24 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 24 results,  Open Access: 10 results) Presentation (22 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] A novel thermos responsible hydrogel composite: Controlled by infra-red irradiation2023

    • Author(s)
      S. Abe, M. NNesabi, S. Safaee, E. Seitoku, Y. Yato, A. Hyono, K. Nakanishi, Y. Era, M. Nakamura, T. Kusaka, A. Valanezhad, T. Takada, and I. Watanabe
    • Journal Title

      Molecular Crystals and Liquid Crystals

      Volume: 755 Issue: 1 Pages: 1-7

    • DOI

      10.1080/15421406.2023.2194600

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative evaluation of three nanofilled resin-based dental composites: cytotoxicity, surface roughness and flexural properties2022

    • Author(s)
      S. Jafarnia, A. Valanezhad*, T. Odatsu, M. Nesabi, S. Safaee, S. Abe, M. Khodaei, S. Shahabi, and I. Watanabe
    • Journal Title

      Polymers and Polymer Composites

      Volume: 30 Pages: 1-8

    • DOI

      10.1177/09673911221087586

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel coating layer on zirconia using modified zinc phosphatizing method2021

    • Author(s)
      KODAMA Kouta、VALANEZHAD Alireza、KHODAEI Mohammad、SAFAEE Sirus、JAFARNIA Shiva、NESABI Mahdis、ABE Shigeaki、WATANABE Ikuya、MURATA Hiroshi
    • Journal Title

      Dental Materials Journal

      Volume: 40 Issue: 4 Pages: 870-876

    • DOI

      10.4012/dmj.2020-253

    • NAID

      130008069736

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2021-07-25
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fabrication of bioactive glass coating on pure titanium by sol-dip method: Dental applications2021

    • Author(s)
      SAFAEE Sirus、VALANEZHAD Alireza、NESABI Mahdis、JAFARNIA Shiva、SANO Hideaki、SHAHABI Sima、ABE Shigeaki、WATANABE Ikuya
    • Journal Title

      Dental Materials Journal

      Volume: 40 Issue: 4 Pages: 949-956

    • DOI

      10.4012/dmj.2020-323

    • NAID

      130008069758

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2021-07-25
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physical and mechanical characteristics of short fiber-reinforced resin composite in comparison with bulk-fill composites2021

    • Author(s)
      Jafarnia Shiva、Valanezhad Alireza、Shahabi Sima、Abe Shigeaki、Watanabe Ikuya
    • Journal Title

      Journal of Oral Science

      Volume: 63 Issue: 2 Pages: 148-151

    • DOI

      10.2334/josnusd.20-0436

    • NAID

      130008009607

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel multi-structural reinforced treatment on Ti implant utilizing a combination of alkali solution and bioactive glass sol2021

    • Author(s)
      Nesabi Mahdis、Valanezhad Alireza、Safaee Sirus、Odatsu Tetsurou、Abe Shigeaki、Watanabe Ikuya
    • Journal Title

      Journal of the Mechanical Behavior of Biomedical Materials

      Volume: 124 Pages: 104837-104837

    • DOI

      10.1016/j.jmbbm.2021.104837

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ion Capture and Release Ability of Glass Ionomer Cement Containing Nanoporous Silica Particles with Different Pore and Particle Size2021

    • Author(s)
      Endo Ryoshun、Nakanishi Ko、Bando Yosuke、Abe Shigeaki、Maruoka Haruhi、Nakamura Mariko、Akasaka Tsukasa、Yoshida Yasuhiro、Sato Yoshiaki
    • Journal Title

      Materials

      Volume: 14 Issue: 19 Pages: 5742-5742

    • DOI

      10.3390/ma14195742

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone Formation Ability and Cell Viability Enhancement of MC3T3-E1 Cells by Ferrostatin-1 a Ferroptosis Inhibitor of Cancer Cells2021

    • Author(s)
      Valanezhad Alireza、Odatsu Tetsurou、Abe Shigeaki、Watanabe Ikuya
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 22 Pages: 12259-12259

    • DOI

      10.3390/ijms222212259

    • NAID

      120007186858

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fabrication of infrared-responsive carbon nanotube coating on glass surface through covalent bond formation using photoreactive silane coupling agent2020

    • Author(s)
      T. Takada, Y. Kitamura, S. Takakuwa
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 128 Issue: 12 Pages: 1066-1071

    • DOI

      10.2109/jcersj2.20152

    • NAID

      130007949045

    • ISSN
      1348-6535, 1882-0743
    • Year and Date
      2020-12-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thermoresponse of poly(acrylamide-<i>co</i>-butyl methacrylate)/polyacrylic acid/MWCNT composite hydrogels observed by infrared irradiation2020

    • Author(s)
      T. Takada
    • Journal Title

      TANSO

      Volume: 2020 Issue: 295 Pages: 135-139

    • DOI

      10.7209/tanso.2020.135

    • NAID

      130007955928

    • ISSN
      0371-5345, 1884-5495
    • Year and Date
      2020-11-15
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Self-assembled monolayer formation on a dental orthodontic stainless steel wire surface to suppress metal ion elution2020

    • Author(s)
      H. Tamaki, S. Abe, S. Yamagata, Y. Yoshida, and Y. Sato
    • Journal Title

      Coatings

      Volume: 20 Issue: 4 Pages: 36701-09

    • DOI

      10.3390/coatings10040367

    • NAID

      120006988210

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bonding performance of a hydrophilic amide monomer containing adhesive to occlusal and cervical dentin2020

    • Author(s)
      E. Seitoku, S. Hoshika, T. Ikeda, S. Abe, T. Tanaka, and H. Sano
    • Journal Title

      Materials

      Volume: 13 Issue: 21 Pages: 472701-08

    • DOI

      10.3390/ma13214727

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fractal dimensional analysis on dispersion/aggregation state of MWCNT in poly(4-chloromethyl)styrene: effect of UV-induced polymer-MWCNT chemical bond formation and its influence in electrical conductivity of their composites2020

    • Author(s)
      Tomoya Takada, Ryoga Ushiromura, Takuto Fushiki
    • Journal Title

      International Journal of Polymer Analysis and Characterization

      Volume: 25 Issue: 4 Pages: 252-261

    • DOI

      10.1080/1023666x.2020.1783079

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Size- and morphology- controlled preparation of surface-modified waterdispersible fullerene nanoparticles for bioapplications2020

    • Author(s)
      H. Oguma, E. Seitoku, M. Mutoh, S. Yoshizawa, K. Nakanishi, Y. Bando, Y. Era, T. Kiba, P. Saikaew, M. Tamai, T. Akasaka, M. Nakamura, T. Kusaka, Y. Yoshida, Y. Sato, H. Sano, S. Abe, .A. Valanezhad, I. Watanabe, S. Inoue, and T. Takada
    • Journal Title

      J. Nanoscience and Nanotechnology

      Volume: 20 Issue: 5 Pages: 2668-2674

    • DOI

      10.1166/jnn.2020.17473

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fabrication and characterization of microcavity organic light-emitting diode with CaF2/ZnS distributed Bragg reflector2020

    • Author(s)
      T. Kitabayashi, T. Asashita, N. Satoh, T. Kiba, M. Kawamura, Y. Abe, K.H. Kim
    • Journal Title

      Thin Solid Films

      Volume: 699 Pages: 13791201-06

    • DOI

      10.1016/j.tsf.2020.137912

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Size dependence of emission enhancement of Tris(8-hydroxyquinolinato) aluminum with plasmonic Al nanostructure2020

    • Author(s)
      N. Iijima, M. Ugajin, T. Kiba, M. Kawamura, Y. Abe, K.H. Kim, A. Higo, J. Takayama S. Hiura, A. Murayama
    • Journal Title

      Thin Solid Films

      Volume: 700 Pages: 13792001-08

    • DOI

      10.1016/j.tsf.2020.137920

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surface-engineered design of efficient luminescent europium(III) complex-based hydroxyapatite nanocrystals for rapid HeLa cancer cell imaging2019

    • Author(s)
      T. Kataoka, S. Abe, and M. Tagaya
    • Journal Title

      ACS Applied Materials & Interfaces

      Volume: 11 Issue: 9 Pages: 8915-8927

    • DOI

      10.1021/acsami.8b22740

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electric Charge Dependence of Controlled Dye-Release Behavior in Glass Ionomer Cement Containing Nano-Porous Silica Particles2018

    • Author(s)
      Bando Y, Nakanishi K, Abe S, Yamagata S, Yoshida Y, Iida J
    • Journal Title

      Journal of Nanoscience and Nanotechnology

      Volume: 18 Issue: 1 Pages: 75-79

    • DOI

      10.1166/jnn.2018.14618

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Calcium charge and release of conventional glass-ionomer cement containing nano porous silica2018

    • Author(s)
      K. Nakamura, S. Abe, H. Minamikawa, and Y. Yawaka
    • Journal Title

      Materials

      Volume: 11, Issue: 8 Pages: 129501-129508

    • DOI

      10.3390/ma11081295

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemical modification to suppress metal ions elution of dental orthodontic wire surface2018

    • Author(s)
      H. Tamaki, S. Tsuchiya, Y. Sakurada, S. Yamagata, A. Hyono, K. Kaneko, K. Kawai, S. Abe, Y. Yoshida, and J. Iida
    • Journal Title

      Molecular Crystals and Liquid Crystals

      Volume: 660 Issue: 1 Pages: 163-172

    • DOI

      10.1080/15421406.2018.1457279

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optical and Chromatic Evaluation of Fluorescent Orthodontic Bonding Materials Doped with a Europium β-diketonate Complex2018

    • Author(s)
      A. Matsumoto, S. Yamagata, S. Abe, T. Akasaka, Y. Yoshida, and J. Iida
    • Journal Title

      Nano Biomedicine

      Volume: 10 Issue: 1 Pages: 3-8

    • DOI

      10.11344/nano.10.3

    • NAID

      130007438742

    • ISSN
      1883-5198, 2185-4734
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optical and chromatic evaluation of fluorescent orthodontic bonding materials doped with a europium β-diketonate complex2018

    • Author(s)
      M. Nishimoto, S. Abe, and T. Yonezawa
    • Journal Title

      New J. Chemistry

      Volume: 42 Issue: 17 Pages: 14493-14501

    • DOI

      10.1039/c8nj01747f

    • NAID

      130007438742

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preparation of calcium phosphate nanoparticles hybridized with europium(III) complex for novel luminescent organic-inorganic systems2018

    • Author(s)
      M. Tagaya, S. Abe, K,i Shinozaki, and T. Kataoka
    • Journal Title

      J. Physics and Chemistry of Solids

      Volume: 122 Pages: 218-226

    • DOI

      10.1016/j.jpcs.2018.06.031

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Light-curing Type Fluorescent Orthodontic Bonding Materials using Europium-β-diketonate Complex2018

    • Author(s)
      S. Yamagata, T. Yamamoto, Y. Sato, S. Abe, T. Akasaka, and Y. Yoshida
    • Journal Title

      Nano Biomedicine

      Volume: 10 Issue: 2 Pages: 53-60

    • DOI

      10.11344/nano.10.53

    • NAID

      130007607966

    • ISSN
      1883-5198, 2185-4734
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] A novel drug releaseable dental materials using nano-structured silica particles2022

    • Author(s)
      S. Abe, M. Nesabi, S. Safaee, S. Iwata, Y. Era, Y. Yatoh, A. Hyono, A. Valanezhad, and I. Watanabe
    • Organizer
      International Dental Material Congress 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脱炭酸酵素(Carbonic Anhydrase)活性中心を模倣した酵素モデル化合物を用いた石灰化反応の制御2022

    • Author(s)
      阿部薫明、江良裕子、高田知哉
    • Organizer
      第49回有機典型化学討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Molecular Design of Organic Radical-Functionalized Graphene: Density Functional Theory (DFT) Study2022

    • Author(s)
      S. Abe, I. Watanabe, and H. Tachikawa
    • Organizer
      MNC2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of thermos responsible composite hydrogels using Carbon Nanotube derivatives2021

    • Author(s)
      Shigeaki Abe, Yuko Era, Alireza Valanezhad, Mariko Nakamura, Tomoya Takada, and Ikuya Watanabe
    • Organizer
      KJF-ICOMEP 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sustainable drug-release property of dental resin composite using nano-porous silica particles2021

    • Author(s)
      Sirus Safaee, Mahdis Nesabi, Shiva Jafarnia, Alireza Valanezhad, Yuko Era, Shigeaki Abe, and Ikuya Watanabe
    • Organizer
      第78回日本歯科理工学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 薬剤徐放能を持つ歯科用コンポジット材料の開発2021

    • Author(s)
      阿部薫明 ,遠藤諒俊, Mahdis Nesabi,Sirus Safaee,Shiva Jafarnia, 岩沼健児, 成徳英理, 中西 康, 江良祐子, Alireza Valanezhad, 中村光一, 高田知哉, 佐藤嘉晃, 渡邊郁哉
    • Organizer
      第43回日本バイオマテリアル学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] ポリアクリルアミド/ポリアクリル酸/MWCNT複合ハイドロゲルの作製と赤外線応答性2021

    • Author(s)
      高田知哉、早坂勇輝、阿部薫明
    • Organizer
      日本化学会第101回春年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Eu(III)錯体を含有したハイドロキシアパタイトナノ粒子の合成と葉酸修飾による細胞標識機能化2021

    • Author(s)
      片岡卓也、阿部薫明、多賀谷基博
    • Organizer
      日本セラミックス協会2021年年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 温度応答により薬剤徐放性を示すハイドロゲルコンポジット材料の開発2020

    • Author(s)
      阿部薫明, 江良裕子, 中西 康, Valanezhad Alireza, 渡邊郁哉
    • Organizer
      第75回日本歯科理工学会
    • Related Report
      2020 Research-status Report
  • [Presentation] ナノ多孔質物質を用いた薬剤徐放能を持つ新規な歯科修復材料の開発2020

    • Author(s)
      成徳英理、江良裕子、阿部薫明、佐野英彦
    • Organizer
      化学系学協会北海道支部2020年冬季研究発表
    • Related Report
      2019 Research-status Report
  • [Presentation] カゴ状ナノシリカ粒子を用いた薬剤徐放性歯科材料の開2019

    • Author(s)
      江良裕子,阿部薫明,赤坂司,吉田靖弘
    • Organizer
      第73回;日本歯科理工学会学術講演
    • Related Report
      2019 Research-status Report
  • [Presentation] Multifunctional surface modification on dental orthodontic wire surface: Suppression of metal ions elution and antibacterial property2019

    • Author(s)
      H. Tamaki, S. Abe, S. Yamagata, Y. Yoshida, J. Iida and Y. Sato
    • Organizer
      Nano Korea 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ナノポーラス物質含有による歯科用シーラント材料から薬剤徐放特性の検討2019

    • Author(s)
      江良裕子,中西 康,阿部薫明,玉井美保,赤坂 司,吉田靖弘
    • Organizer
      第74回日本歯科理工学会学術講演
    • Related Report
      2019 Research-status Report
  • [Presentation] Drug release behavior from dental/medical materials using nanoporous silica2019

    • Author(s)
      Y. Era, F. Farhana, S. Iwata, S. Abe, M. Nakamura, I. Watanabe, and Y. Yoshida
    • Organizer
      Chitose International Forum 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ナノ多孔質シリカの孔サイズがもたらすイオン放出能への影響2019

    • Author(s)
      遠藤諒俊、中西 康、坂東洋祐、松本愛子、阿部薫明、山方秀一、吉田靖弘、佐藤嘉晃
    • Organizer
      第78回日本矯正歯科学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Model drug-released behavior from medical materials using nanoporous silica2019

    • Author(s)
      E. Seitoku, K. Nakanishi, Y. Bandoh, Y. Era, S. Iwata, S. Abe, M. Nakamura, I. Watanabe, and H. Sano
    • Organizer
      19th Asian BioCeramics Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] カゴ状ナノシリカ粒子を用いた薬剤徐放性歯科材料の開発2019

    • Author(s)
      江良裕子,阿部薫明,赤坂司,吉田靖弘
    • Organizer
      第73回歯科理工学春季学術討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] Photoluminescent and biocompatible property of folic acid derivative immobilized apatite/Eu-complex hybrid particles for biomedical tool2018

    • Author(s)
      S. Abe, T. Kataoka M. Tagaya
    • Organizer
      NanoKorea 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cytocompatibility of nano-porous silica using for novel controlled drug-release materials2018

    • Author(s)
      E. Seitoku, S. Abe, Y. Banjo, K. Nakanishi, S. Kakuda, J. Iida, Y. Yoshida, H. Sano
    • Organizer
      IADR-PER 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] Size- and morphology- controlled preparation of surface-modified water-dispersible fullerene nanoparticles for bioapplications2018

    • Author(s)
      Y. ERA, E. SEITOKU, S. ABE, T. KIBA, M. NAKAMURA, Teruo KUSAKA,, S. INOUE, Y. YOSHIDA, H. SANO, and T. TAKADA
    • Organizer
      KJF
    • Related Report
      2018 Research-status Report
  • [Presentation] 多孔質シリカを用いた選択的薬剤徐放を実現する歯科用材料の開発2018

    • Author(s)
      江良裕子,中西康,阿部薫明,玉井美保,赤坂司,吉田靖弘
    • Organizer
      第72回歯科理工学秋季学術討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] Controlled drug release property of nano-porous silica micro particles and their cytocompatibility2018

    • Author(s)
      E. Seitoku, Y. Era, S. Abe, M. Nakamura, T. Kusaka, S. Inoue, Y. Yoshida, H. Sano
    • Organizer
      Bioceramics 30
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi