| Project/Area Number |
18K09618
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57040:Regenerative dentistry and dental engineering-related
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡辺 孝康 日本大学, 歯学部, 助教 (70725514)
中川 一路 京都大学, 医学研究科, 教授 (70294113)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 歯科インプラント / 細菌 / インプラント / 感染症 / 細菌叢 |
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| Outline of Final Research Achievements |
As dental implants are placed into the jawbone, biofilm which is composed of numerous microorganisms is formed at the transmucosal area. Microbiota which consist biofilm around implants is known to be altered by oral hygiene conditions. This event is considered to lead to the onset or progression of peri-implant inflammation and peri-implantitis which exhibit bone resorption. However, it is still not clear how indigenous microbiota around implants are established and be affected by environmental factors. Therefore, we conducted a comprehensive study by collecting peri-implant biofilms from patients with ongoing implant therapy. Samples were collected time-serially post exposure of implant to oral cavity. We investigated the bacterial species composing the biofilms at each time point. As a result, until 2 weeks post implant exposure, the composition of biofilms among patients did not differ. However, after 4 weeks, the composition or the abundance of bacterial species varied.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果から，無菌状態にあるインプラントが口腔内に露出してから非常に早期の段階で細菌叢が定着している事が明らかとなった．その上で、創傷治癒を完了した時点で個々の患者毎に特有の細菌構成となっており，患者の持っている環境因子，すなわち口腔疾患や全身疾患，生活習慣といったものの影響を非常に強く受けていることが示唆された．このことから，口腔内環境を悪化させる方向に変化させる環境因子の改善が細菌学的にも有効であることの立証への足掛かりとなるものと考えられる．
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