| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
To develop an iodine contrast agent that can be used even by patients with iodine hypersensitivity, it is necessary to develop an iodine contrast agent that suppresses the dissociation of iodine bonds. In this study, we aimed to develop a new contrast agent that coats the iodine unit using molecular-sized capsules. From the analysis of the UV/Vis absorption spectrum, it was revealed that the novel tripod ligand L and Zn2+ form a 1:1 complex. This result was also confirmed by MALDI-TOF-MS. Analysis of the NMR spectrum revealed that choline is encapsulated inside the complex of Zn2+ and L, and it was found that the complex of Zn2+ and L forms a molecular capsule that can coat molecules.
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