| Project/Area Number |
18K09648
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57040:Regenerative dentistry and dental engineering-related
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
Maruta Michito 福岡歯科大学, 口腔歯学部, 准教授 (40507802)
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| Co-Investigator(Kenkyū-buntansha) |
荒平 高章 福岡歯科大学, 口腔歯学部, 助教 (30706958)
泉 利雄 福岡歯科大学, 口腔歯学部, 教授 (40248547)
梶本 昇 福岡歯科大学, 口腔歯学部, 助教 (30824213)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 骨補填材 / 多孔体 / 溶解析出反応 / リン酸三カルシウム / 溶解性 / 炭酸基 / 歯科用石膏 / マグネシウム / 溶解析出 / 人工骨補填材 |
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| Outline of Final Research Achievements |
Semi-hydrated gypsum in dentistry was used as a starting material. This study established how to prepare a porous body with a three-dimensional interconnecting porous structure. Typically, it is known that hydroxyapatite is formed when gypsum is hydrothermally treated, but in this study, a method that can stabilize the precipitation of beta-tricalcium phosphate is a semi-stable phase by using an additive.
The porous gypsum body to which magnesium was added was phase-converted to beta-type calcium phosphate by adjusting the amount of magnesium added and the hydrothermal treatment temperature. It has become possible to develop a porous body that can adjust the porosity by creating a template with a 3D printer and using the curing reaction of gypsum.
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| Academic Significance and Societal Importance of the Research Achievements |
ベータ型リン酸三カルシウムは1050℃以上になるとアルファ型リン酸三カルシウムへと相転移（β→α転移）を開始してしまいます。そのため、1050℃より低い温度で焼結させなければならず、焼結密度が低く、強度も小さくなってしまいます。つまり、高温焼結によるベータ型リン酸三カルシウム合成法では内部気孔率（または気孔径）を下げることでしか圧縮強度を向上させることはできません。本研究では低い結晶性を有する完全連通気孔構造を持つ新規ベータ型リン酸三カルシウムの調製法を明らかにした。
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