Establishment of bone reconstruction using bioactive porous titanium porous that enables implant stability

• Project/Area Number: 18K09683
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Hiroshima University
• Principal Investigator: Doi Kazuya 広島大学, 医系科学研究科(歯), 助教 (80444686)
• Co-Investigator(Kenkyū-buntansha): 久保 隆靖 広島大学, 病院(歯), 講師 (60240876) ; 沖 佳史 広島大学, 医系科学研究科(歯), 助教 (80806571)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 骨再建 / インプラント / チタン多孔体 / 生体活性 / 多孔性チタン

Outline of Final Research Achievements

The presented study investigated the stability of implants after bone　reconstruction with bioactive porous titanium. The bioactive porous titanium showed an apatite formation promoting action in the simulated body fluid. In addition, in the rabbit femur implantation test, the bioactive porous titanium promoted bone formation from the surroundings bone, and the result of bone formation ratio was significantly higher than that of the other comparative groups. Furthermore, when the implant was implanted in the site where the bone was reconstructed with a bioactive porous titanium, osseointegration was established, and the results showed that the implant was well supported.

Academic Significance and Societal Importance of the Research Achievements

顎骨広範囲骨欠損の骨再建にはチタンプレートなど緻密体の骨再建材料が用いられているが，形態的回復が難しくかつ内部への骨形成は困難である．そのため骨再建後のインプラント治療などは困難であり，十分な機能回復が得られない．チタン多孔体は内部への骨伝導が可能な立体構造を有しており，さらに同部へのインプラント治療が可能である結果を示した．チタン材料で骨再建した部位へのインプラント体のオッセオインテグレーションの確立は初めての報告であり，学術的にも大きな意義を持つと考えられる．

Research Products

• [Journal Article] Osseointegration Aspects of Implants at the Bone Reconstruction Site by a Novel Porous Titanium Scaffold (2021)
  • Author(s): Doi Kazuya、Kobatake Reiko、Makihara Yusuke、Oki Yoshifumi、Umehara Hanako、Kubo Takayasu、Tsuga Kazuhiro
  • Journal Title: Journal of Oral and Maxillofacial Research Volume: 12 Issue: 3
  • DOI: 10.5037/jomr.2021.12304
  • Peer Reviewed / Open Access
• [Journal Article] The development of novel bioactive porous titanium as a bone reconstruction material. (2020)
  • Author(s): Doi K, Kobatake R, Makihara Y, Oki Y, Umehara H, Kubo T, Tsuga K
  • Journal Title: RSC Advances Volume: 10 Issue: 38 Pages: 22684-22690
  • DOI: 10.1039/d0ra03202f
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparative study of surface modification treatment for porous titanium. (2020)
  • Author(s): Kobatake R, Doi K, Oki Y, Makihara Y, Umehara H, Kubo T, Tsuga K.
  • Journal Title: J Oral Maxillofac Res. Volume: 11 Issue: 2
  • DOI: 10.5037/jomr.2020.11205
  • Peer Reviewed / Open Access
• [Journal Article] Development of a novel bioactive titanium membrane with alkali treatment for bone regeneration (2020)
  • Author(s): Umehara H, Doi K, Oki Y, Kobatake R, Makihara Y, Kubo T, Tsuga K
  • Journal Title: Dent mater J Volume: in press
  • NAID: 130007911289
  • Peer Reviewed / Open Access
• [Journal Article] 新規チタン多孔体による顎骨再建療法への試み (2020)
  • Author(s): 土井一矢
  • Journal Title: デンタルダイヤモンド Volume: 4 Pages: 102-106
• [Journal Article] Effect of Autoclave heat sterilization on the surface properties of the sodium titaniate hydrogel layer on the alkali-treated titanium membrane (2019)
  • Author(s): Umehara H, Doi K, Kobatake R, Oki Y, Makihara Y, Kubo T, Tsuga K
  • Journal Title: 広大歯誌 Volume: 51 Pages: 85-90
  • Peer Reviewed
• [Journal Article] Novel fabrication of porous titanium by a resin-impregnated titanium substitution technique for bone reconstruction (2019)
  • Author(s): Kobatake R, Doi K, Kubo T, Makihara Y, Oki Y, Yokoi M, Umehara H, Tsuga K
  • Journal Title: RSC Advances Volume: 9 Issue: 3 Pages: 1625-31
  • DOI: 10.1039/c8ra08744j
  • Peer Reviewed / Open Access
• [Presentation] Newly development of porous titanium bone reconstruction material which enables implant treatment (2021)
  • Author(s): Wakamatsu K, Doi K, Kobatake R, Makihara Y, Oki Y, Umehara H, Kubo T, Tsuga K
  • Organizer: 6th Joint Scientific Meeting in Dentistry (JSMiD), Web, 2021.
  • Int'l Joint Research
• [Presentation] Osseointegration aspects of placed implant in bone reconstruction with newly developed porous titanium (2021)
  • Author(s): Kobatake R, Doi K, Makihara Y, Oki Y, Umehara H, Kubo T, Gruber R, Tsuga K
  • Organizer: 7th Biennial joint congress of JPS-CPS-KAP
  • Int'l Joint Research
• [Presentation] スポンジ状チタンおよびマイクロメッシュチタン薄膜による生物応答 (2019)
  • Author(s): 土井一矢
  • Organizer: 科学技術振興機構（JST）広島大学-新技術説明会
  • Invited
• [Presentation] Novel fabrication of bioactive porous titanium for bone reconstruction (2019)
  • Author(s): KobatakeR, Doi K, Makihara Y, Oki Y, Umehara H, Oue H, Abe Y, Kubo T, Tsuga K
  • Organizer: DENTISPHERE 4-International Scientific Meeting, 5th Asean plus, Tokushima joint international conference
  • Int'l Joint Research
• [Presentation] The bioactive effect of alkali treated titanium membrane (2019)
  • Author(s): Umehara H, Doi K, Kobatake R, Oki Y, Makihara U, Kubo T, Tsuga K
  • Organizer: DENTISPHERE 4-International Scientific Meeting, 5th Asean plus, Tokushima joint international conference
  • Int'l Joint Research
• [Presentation] Biology of Non-absorbable Material in Implant Treatment (2019)
  • Author(s): Doi K
  • Organizer: DENTISPHERE 4-International Scientific Meeting, 5th Asean plus, Tokushima joint international conference
  • Int'l Joint Research / Invited
• [Presentation] インプラント骨造成に用いる非吸収性人工骨のバイオロジー (2018)
  • Author(s): 土井一矢
  • Organizer: 第61回秋季日本歯周病学会
  • Invited
• [Presentation] 新規生体活性チタンメンブレンの材料特性および生体活性の検討 (2018)
  • Author(s): 土井一矢，久保隆靖，小畠玲子，沖 佳史，梅原華子，牧原勇介，津賀一弘
  • Organizer: 第48回日本口腔インプラント学会学術大会
• [Presentation] Osseointegration aspect of implants placed in bone reconstructed site with novel porous titanium (2018)
  • Author(s): Kobatake R, Doi K, Oki Y, Yokoi M, Makihara Y, Umehara H, Kubo T, Tsuga K
  • Organizer: 27th annual scientific meeting of European association for osseointegration
  • Int'l Joint Research
• [Patent(Industrial Property Rights)] 多孔金属薄膜 (2019)
  • Inventor(s): 土井一矢，小畠玲子，藤田 剛，梅原華子，久保隆靖
  • Industrial Property Rights Holder: 広島大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019