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Investigation pf a novel sterilisation method by peroxynitric acid for peri-implant infection

Research Project

Project/Area Number 18K09685
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionKyushu University

Principal Investigator

Esaki Daisuke  九州大学, 歯学研究院, 共同研究員 (10608970)

Co-Investigator(Kenkyū-buntansha) 都留 朋子  九州大学, 大学病院, 医員 (40823612)
松下 恭之  九州大学, 大学病院, 准教授 (60159150)
鮎川 保則  九州大学, 歯学研究院, 教授 (50304697)
古谷野 潔  九州大学, 歯学研究院, 特別教員 (50195872)
神野 洋平  九州大学, 大学病院, 助教 (40507779)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords歯科インプラント治療 / インプラント周囲炎 / 過硝酸 / 歯科用インプラント / 殺菌 / インプラント / PNA
Outline of Final Research Achievements

This research evaluated the bactericidal effects of peroxynitric acid (HOONO2; PNA) on biofilms formed on titanium surfaces. Streptococcus gordonii was cultured on titanium discs that were then used to evaluate the bactericidal effects of PNA. Using low concentration of PNA, the bacterial count based on a CFU assay reached an undetectable level within 10 s.Bacillus subtilis solution was coated on the dental model, and impression taking of the model was done by dental impression material. Dental impression material was disinfected by PNA, and bactericidal effects were evaluated. The bacterial count based on a CFU assay reached an undetectable level within 10 minutes.
PNA is useful for sterilizing biofilms on titanium surfaces and dental impression material that have been contaminated with bacteria.

Academic Significance and Societal Importance of the Research Achievements

歯科インプラント治療は歯科補綴治療の選択肢として需要な位置を占める治療法である。しかし、近年インプラント周囲炎の問題が大きく取り上げられており、その治療法についても絶対的な方法はない。そこで過硝酸の殺菌効果に着目し、インプラント周囲炎の治療法に応用するための基礎実験を行い、良好な結果を得た。過硝酸の歯科材料の消毒への応用を目指した基礎実験も行い、良好な結果を得た。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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