| Project/Area Number |
18K09705
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
近藤 祐介 九州歯科大学, 歯学部, 講師 (00611287)
柄 慎太郎 九州歯科大学, 歯学部, 特別研修員 (20759386)
細川 隆司 九州歯科大学, 歯学部, 教授 (60211546)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ビタミンK / 骨代謝 / インプラント / 骨質 / 骨代謝マーカー |
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| Outline of Final Research Achievements |
Vitamin K2, also called menaquinone (MK), inhibits bone loss in postmenopausal women. We demonstrate the microstructural and mechanical properties of bone recovery in ovariectomized (OVX) rats during MK-7 administration. Bilateral ovariectomy and a sham operation were performed on 14-week-old female Wistar rats. MK-7 was orally administered at 30 mg/kg daily for 12 weeks. The femur was used for the 3-point bending test and microstructural analysis by micro-CT, and the mandibular cortical bone for the nanoindentation test. Micro-CT revealed that MK-7 group had greater bone volume per tissue volume and a higher trabecular number than the OVX group. The bulk-scale 3-point bending test did not allow the mechanical properties between OVX and OVX/MK7 groups to be discerned, yet at the smallest level, the elastic-plastic transition point of the nanoindentation stress-strain curve of the mandibular cortical bone was higher in the MK-7 group than in the OVX group.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでのインプラントの術前CT検査では，骨密度の指標であるCT値で評価するのみであり，骨質を含めた骨強度の評価はできていないのが現状である．本研究では骨粗鬆症モデルラットに対し，ビタミンK2であるメナキノン7を投与したところ，大腿骨の骨質が改善されただけでなく，顎骨のナノレベルでの機械的強度が改善することが示された．本研究の結果より，閉経後の女性患者にインプラント治療を行う場合，術前に血中ucOC量などでビタミンK2の摂取状況を把握し，積極的な栄養指導を行っていくことが有効である可能性が示唆された．
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