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A new model construction of deglutition using high resolution 3DCT images

Research Project

Project/Area Number 18K09706
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionIwate Medical University

Principal Investigator

Sahara Yoshinori  岩手医科大学, 歯学部, 教授 (40206008)

Co-Investigator(Kenkyū-buntansha) 道脇 幸博  昭和大学, 歯学部, 兼任講師 (40157540)
千葉 俊美  岩手医科大学, 歯学部, 教授 (40254784)
橋本 卓弥  東京理科大学, 工学部機械工学科, 講師 (60548163)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords嚥下 / 画像解析 / コンピュターシュミレーション / 4次元CT画像 / 嚥下生体モデル / 嚥下筋駆動型モデル / 嚥下運動 / CT画像解析 / 舌骨運動軌跡 / 筋電図 / 筋骨格モデル / バイオメカニクス / 誤嚥 / CT / マノメーター / シュミレーションモデル
Outline of Final Research Achievements

During swallowing a large number of organs work in a coordinated manner, yet medical images taken by CT or VF can hardly visualize the complex motion of swallowing with sufficient temporal and spatial resolution. Taking use of 3D images by a 320ADCT with a newly developed segmentation method, we have visualized not only bolus, bone and cartilage, but also soft tissues. We have also successfully simulated hyoid muscles activities and laryngeal muscles activities during a whole sequence of swallowing with different algorithms. These results could help further understanding of the mechanism of deglutition and aspiration.

Academic Significance and Societal Importance of the Research Achievements

嚥下研究において、①医用画像(CT,VF, MRI)と解剖の知識を統合した生体モデル、②嚥下時の生体現象を数理モデル化、③嚥下時の食品データを数理モデル化し、コンピュータ・シミュレーションがおこなわれてきた。320列面検出型CTによる高精度、高分解能3次元画像を基にした精緻なモデルは、嚥下の研究・臨床での利用価値は高く、関連する様々な分野で有効なツールになり得ると予想される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (19 results)

All 2021 2020 2019

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (12 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results)

  • [Journal Article] コンピュータシミュレーションによって嚥下の解明をめざす2021

    • Author(s)
      道脇幸博,菊地貴博,外山義雄,神谷 哲
    • Journal Title

      歯科理工学会雑誌

      Volume: 40 Pages: 21-24

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Realistic computer simulation of bolus flow during swallowing.2020

    • Author(s)
      Michiwaki Y, Kamiya T, Kikuchi T, Toyama Y, Takai M, Hanyu K, Inoue M, Yahiro N, Koshizuka S.
    • Journal Title

      Food Hydrocoll.

      Volume: 108 Pages: 106040-106040

    • DOI

      10.1016/j.foodhyd.2020.106040

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Musculoskeletal Model of Hyolaryngeal Elements for Understanding Pharyngeal Swallowing Mechanics2020

    • Author(s)
      Hashimoto Takuya、Urabe Mariko、Chee-Sheng Foo、Murakoshi Atsuko、Kikuchi Takahiro、Michiwaki Yukihiro、Koike Takuji
    • Journal Title

      Applied Sciences

      Volume: 10 Issue: 18 Pages: 6276-6276

    • DOI

      10.3390/app10186276

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An fMRI Study of Brain Network Involved in Teeth Tapping in the Elderly.2020

    • Author(s)
      T. Kobayashi, H Fukami, E Ishikawa, K Shibata, M Kubota, H Kondo, Y. Sahara
    • Journal Title

      Front Aging Neurosci.

      Volume: 12 Pages: 32-32

    • DOI

      10.3389/fnagi.2020.00032

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum and saliva cytokines levels in an patients with brain abscess due to periodontitis.2020

    • Author(s)
      O. Murai, T. Chiba, D. Sasaki , Y. Sahara, T. Yaegashi
    • Journal Title

      Medical Research Archives

      Volume: 8 Pages: 1-16

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computational modeling of child’s swallowing to simulate choking on toys.2019

    • Author(s)
      Yukihiro Michiwaki, Takahiro Kikuchi, Tetsu Kamiya, Yoshio Toyama, Motoki, Inoue, Keigo Hanyuu, Megumi Takai & Seiichi Koshizuka
    • Journal Title

      Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization,

      Volume: 8 Issue: 3 Pages: 1-7

    • DOI

      10.1080/21681163.2019.1647458

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 嚥下障害と介護食レオロジー2019

    • Author(s)
      水沼 博、道脇幸博
    • Journal Title

      化学工学

      Volume: 83 Pages: 473-476

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 動態力学シミュレーションによる嚥下機能の解析2021

    • Author(s)
      道脇幸博
    • Organizer
      日本嚥下医学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 嚥下の筋骨格モデル2021

    • Author(s)
      橋本卓弥
    • Organizer
      日本嚥下医学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Swallowing Musculoskeletal Analysis Using 320-ADCT.2020

    • Author(s)
      T. Hashimoto, T. Kikuchi, Y. Michiwaki
    • Organizer
      International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of muscle activity in tongue's motion considering distinguished muscle fibers.2020

    • Author(s)
      S. Ono, H. Azegami, K. Takeuchi, Y. Michiwaki, T. Kikuchi
    • Organizer
      Asian Congress of Structural and Multidisciplinary Optimization 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Muscle-driven swallowing simulation to elucidate the neuromuscular system functioning underlying human swallowing.2020

    • Author(s)
      Y. Michiwak, T. Kikuchi, T. Kamiya, Y. Toyama, M. Takai, M. Inoue, N. Yahiro, M. Urabe, T. Hashimoto, T. Ijiri, Y. Sahara, S. Koshizuka
    • Organizer
      日本神経科学学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Harmonic Coordinateを用いた自由形状変形法による嚥下4次元CT画像の領域分割2020

    • Author(s)
      菊地貴博,井尻敬 ,才藤栄一,稲本陽子,道脇幸博
    • Organizer
      Visual Computing
    • Related Report
      2020 Annual Research Report
  • [Presentation] Biomechanical simulation of swallowing and aspiration.2019

    • Author(s)
      Y Michiwaki, T Kikuchi, T Kamiya, Y Toyama, M Takai, M Inoue, N Yahiro, M Urabe, T Hashimoto, T Ijiri, H Shinozaki, Y Sahara, S Koshizuka
    • Organizer
      Medical Engineering of Orofacial Laryngopharyngeal Function
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] An fMRI Study of Brain Network Involved in Elderly Teeth Tapping.2019

    • Author(s)
      Y Sahara, H Fukami
    • Organizer
      Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Exploration of brain region relevant to sweet-sour taste interactions by using fMRI.2019

    • Author(s)
      H Fukami, N Ono, S Mori, A Kitamura, Y Sahara
    • Organizer
      European Chemoreception Research Organization
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Computer simulation of swallowing to reveal food features related to aspiration,2019

    • Author(s)
      Y Michiwaki, T Kikuchi, T Kamiya, Y Toyama, M Takai, M Inoue, N Yahiro, K Hanyuu, S Koshizuka
    • Organizer
      NSFC-JSPS Joint Symposium Hydrocolloids for Modern Food Function Design,
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 加齢変化と嚥下障害―コンピュータシミュレーションによるモデル化と解析2019

    • Author(s)
      道脇幸博,橋本卓弥,菊地貴博,占部麻里子,佐原資謹
    • Organizer
      認知症と口腔機能研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] An fMRI Study of Brain Network Involved in Elderly Teeth Tapping.2019

    • Author(s)
      Y. Sahara, H. Fukami
    • Organizer
      Federation of the Asian and Oceanian Physiological Societies Congress,
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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