Creation of biomaterials expected to control bone quality in the elderly and application to implants
| Project/Area Number |
18K09713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小正 裕 大阪歯科大学, 医療保健学部, 教授 (10131385)
小正 聡 大阪歯科大学, 歯学部, 講師 (70632066)
岡崎 定司 大阪歯科大学, 歯学部, 教授 (80169094)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | PEEK / インプラント / in vitro / in vivo / ナノ構造 |
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| Outline of Final Research Achievements |
Various coating methods have been attempted to improve the biological properties of PEEK materials. Among them, it is shown that surface modification with titanium nanostructures on the PEEK surface increases hydrophilicity and promotes early cell adhesion and induction of hard tissue differentiation.However, the biocompatibility of this material is not clear.Therefore, in this study, we investigated how the nanostructure treatment of pure titanium metal-deposited PEEK material affects the behavior of rat bone marrow cells. As a result, the pure titanium metal was coated by plasma treatment to precipitate nanostructures. Part of the possibility that the surface of PEEK material exhibits high ability to induce hard tissue differentiation was shown.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の学術的な特色は，ナノテクノロジーの一つである材料表面のナノ構造制御に着目し，新たな生体材料を開発し他分野への応用を視野に入れているという点にある．また，構造制御の方法も比較的簡易であることから，PEEKインプラント材料の生体親和性の著しく向上することが期待でき，この結果は医科界・歯科界において多くの患者に普及させることを期待できる．
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Amelogenin promotes bone regeneration using human dental pulp cells on modified titanium nanostructures2019
Author(s)
Komasa S, Takao S, Zhang H, Li M, Yan S, Zeng Y, Yang Y, XU HANG, Kashiwagi K, Kusumoto T, Yoshimine S, Nishizaki H, Komasa Y, Okazaki J, Kawazoe T
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Journal Title
The Journal of Japan Association of Oral rehabiitation
Volume: 32
Pages: 32-45
NAID
Related Report
Peer Reviewed
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[Journal Article] Optimized Surface Characteristics and Enhanced in Vivo Osseointegration of Alkali-Treated Titanium with Nanonetwork Structures2019
Author(s)
Zeng Y, Yang Y, Chen L, Yin D, Zhang H, Tashiro Y, Inui S, Kusumoto T, Nishizaki H, Sekino T, Okazaki J, Komasa S
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Journal Title
International Journal of Molecular Sciences
Volume: 20(5)
Related Report
Peer Reviewed / Open Access
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[Journal Article] Osseointegration of Alkali-Modified NANOZR Implants: An In Vivo Study2019
Author(s)
Komasa S, Nishizaki M, Zhang H, Takao S, Yin D, Terada C, Kobayashi Y, Kusumoto T, Yoshimine S, Nishizaki H, Okazaki J, Chen L
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Journal Title
International Journal of Molecular Sciences
Volume: 20(4)
Related Report
Peer Reviewed / Open Access
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[Presentation] 大気圧プラズマ処理が新規セラミック材料表面に与える影響2019
Author(s)
高尾誠二, 小正 聡, 上り口晃成, 曽 昱豪, 楊 元元, 李 敏, Yan Sifan, 楠本哲次, 西崎 宏, 吉峰茂樹, 岡崎定司
Organizer
令和元年度日本補綴歯科学会関西支部学術大会
Related Report
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[Presentation] 濃アルカリ処理を施したナノジルコニアへの大気圧プラズマ処理が与える影響について2019
Author(s)
高尾誠二, 小正 聡, 上り口晃成, 曽 昱豪, 楊 元元, 松本卓巳, 楠本哲次, 吉峰茂樹, 西崎 宏, 小正 裕, 岡崎定司
Organizer
公益社団法人日本補綴歯科学会第128回学術大会
Related Report
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[Presentation] アルカリ処理したナノジルコニアとナノ構造析出純チタン金属表面上の硬組織分化誘導関連の遺伝子発現の比較2018
Author(s)
小正 聡, 西崎 真理子, 寺田 知里, Chen Luyuan, 波床 真依, 尹 德栄, 高尾 誠二, 楠本 哲次, 西崎 宏, 吉峰 茂樹, 小正 裕, 岡崎 定司
Organizer
第32回口腔リハビリテーション学会学術大会
Related Report
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