Minimum Invasive Surgery with using Barrier Theory Construction against the Invasion of Tongue Cancer
Project/Area Number |
18K09742
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 57060:Surgical dentistry-related
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Research Institution | Osaka University |
Principal Investigator |
OKURA MASAYA 大阪大学, 大学院歯学研究科, 招へい教員 (10281130)
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Project Period (FY) |
2018-04-01 – 2023-03-31
|
Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 口腔癌 / 舌癌 / 浸潤様式 / 生存率 / 累積死亡率 / BMI / TNM分類 / QOL / 予後 / 局所浸潤 / 腫瘍浸潤周囲環境 / minimum invasive surgery / 舌部節 |
Outline of Final Research Achievements |
Oral function analysis after oral cancer treatment showed that the amount of mouth opening and the number of teeth associated with contralateral occlusion were determinants of the foods eaten and the range of food choices for eating out. Level IV/V metastasis was an even stronger high-risk group for oral cancer, and adjuvant therapy was non-inferior to RT alone and to CCRT. The invasion of cancer cells into the tongue was determined to be a rare case of invasion into the muscle scaffold, causing an inflammatory reaction around the cancer cells, inducing a peritumoral stromal reaction Desmoplasia, and invading the stroma into the scaffold. Low pretreatment body weight was found to be associated with an increased risk of lymph node metastasis and further distant metastasis, leading to increased disease-specific cumulative mortality.
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Academic Significance and Societal Importance of the Research Achievements |
本研究によって、希少癌に分類される口腔癌について様々なEBMを日本人で検証することができた。欧米と同じ結果のものは少なく、日本人に限定された結果を示すものであった。これらの結果は、術前の評価すべき項目、手術法の選択、術後のAdjuvant療法の選択など、今後の臨床に大きく役立つものである。 舌癌の浸潤様式は、新しい知見が得られた。この知見を完全に証明することが今後の課題であるが、舌癌切除法のMinimum Invasive Surgeryを確立できると考えている。
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Report
(6 results)
Research Products
(26 results)
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[Journal Article] Oral melanoma: a multicenter study of 69 patients from Japan2022
Author(s)
Yamada Shin-ichi、Hasegawa Takumi、Yamakawa Nobuhiro、Tamura Masashi、Takizawa Atsushi、Kakei Yasumasa、Okura Masaya、Naruse Tomofumi、Otsuru Mitsunobu、Rin Shin、Ueda Michihiro、Yamashita Tetsuro、Kirita Tadaaki、Ota Yoshihide、Kurita Hiroshi
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Journal Title
Clinical Oral Investigations
Volume: 26
Issue: 10
Pages: 6187-6193
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Muticenter retrospective study of weekly cetuximab plus paclitaxel for recurrent or metastatic oral squamous cell carcinoma2021
Author(s)
TOMOFUMI NARUSE1, SOUICHI YANAMOTO1, MITSUNOBU OTSURU1, NOBUHIRO YAMAKAWA2, TADAAKI KIRITA2, YUKARI SHINTANI3, TATSUSHI MATSUMURA3, MASAYA OKURA4,5, MASASHI SASAKI6, YOSHIHIDE OTA6, SHIN-ICHI YAMADA7, HIROSHI KURITA7 and MASAHIRO UMEDA1; JAPAN ORAL ONCOLOGY GROUP (JOOG)
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Journal Title
Anticancer Res
Volume: 41
Issue: 11
Pages: 5785-91
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] General rules for clinical and pathological studies on oral cancer (2nd edition): a synopsis2021
Author(s)
Ota Y, Noguchi T, Ariji E, Fushimi C, Fuwa N, Harada H, Hayashi T, Hayashi R, Honma Y, Miura M, Mori T, Nagatsuka H, Okura M, Ueda M, Uzawa N, Yagihara K, Yagishita H, Yamashiro M, Yanamoto S, Kirita T
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Journal Title
Int J Clin Oncol
Volume: 26
Issue: 4
Pages: 623-35
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Postoperative adjuvant therapy for patients with loco-regionally advanced oral squamous cell carcinoma who are at high risk of recurrence.2020
Author(s)
Yanamoto S, Denda Y, Ota Y, Hasegawa T, Akashi M, Okura M, Yamada SI, Kurita H, Yamakawa N, Kirita T, Ueda M, Umeda M; Japan Oral Oncology Group (JOOG)
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Journal Title
Int J Oral Maxillofac Surg
Volume: 49
Issue: 7
Pages: 848-853
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical Significance of the G8 Screening Tool in Elderly Patients With Oral Squamous Cell Carcinoma2020
Author(s)
Yamada SI, Hasegawa T, Okuyama K, Yamakawa N, Okura M, Hashidume M, Yanamoto S, Akashi M, Kirita T, Umeda M, Kurita H.
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Journal Title
Clin Oral Investig
Volume: 24
Issue: 6
Pages: 1953-1961
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Multicenter retrospective study of the prognosis and treatment outcomes of Japanese oral squamous cell carcinoma patients with level IV/V metastasis.2019
Author(s)
Hasegawa T, Yanamoto S, Otsuru M, Kakei Y, Okura M, Yamakawa N, Yamada SI, Ota Y, Umeda M, Kirita T, Kurita H, Ueda M, Komori T; Japan Oral Oncology Group (JOOG)
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Journal Title
Head & Neck
Volume: 41
Issue: 7
Pages: 2256-2263
DOI
Related Report
Peer Reviewed
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[Journal Article] Tumor budding and adjacent tissue at the invasive front correlate with delayed neck metastasis in clinical early-stage tongue squamous cell carcinoma.2019
Author(s)
Yamakawa N, Kirita T, Umeda M, Yanamoto S, Ota Y, Otsuru M, Okura M, Kurita H, Yamada SI, Hasegawa T, Aikawa T, Komori T, Ueda M; Japan Oral Oncology Group (JOOG)
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Journal Title
J Surg Oncol
Volume: 119
Issue: 3
Pages: 370-378
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching.2019
Author(s)
Otsuru M, Ota Y, Yanamoto S, Okura M, Umeda M, Kirita T, Kurita H, Ueda M, Komori T, Yamakawa N, Kamata T, Hasegawa T, Shibahara T, Ohiro Y, Yamashita Y, Noguchi K, Noguchi T, Karakida K, Naito H, Aikawa T, Yamashita T, Kabata D, Shintani A.
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Journal Title
Ann Surg Oncol.
Volume: 26
Issue: 2
Pages: 555-563
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] 早期舌扁平上皮癌における頸部後発転移の新たな予測因子2021
Author(s)
山川延宏1,8,桐田忠昭1,8,梅田正博2,8,柳本惣市2,8,大鶴光信2,8,大倉正也3,8,相川友直3,8,太田嘉英4,8,栗田 浩5,8,山田慎一5,8,明石昌也6,8,長谷川巧実6,8,上田倫弘
Organizer
日本頭頚部癌学会
Related Report
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[Presentation] 希少がんである口腔癌を多方面から考える 早期舌癌における頸部後発転移に対する新規予測因子の検討2018
Author(s)
山川 延宏, 桐田 忠昭, 梅田 正博, 柳本 惣市, 太田 嘉英, 大鶴 光信, 大倉 正也, 相川 友直, 栗田 浩, 山田 慎一, 古森 孝英, 長谷川 巧実, 上田 倫弘, 日本口腔がん臨床研究グループ
Organizer
56回日本癌治療学会学術集会
Related Report
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[Presentation] Prevention of surgical site infection after oral cancer surgery by topical tetracycline: Results of a multicenter randomized control trial.2018
Author(s)
Madoka Funahara, Souichi Yanamoto, Michihiro Ueda, Takatsugu Suzuki, Yoshihide Ota, Fumihiro Nishimaki, Hiroshi Kurita, Nobuhiro Yamakawa, Tadaaki Kirita, Masaya Okura, Yasuaki Mekaru, Keiichi Arakaki, Masahiro Umeda
Organizer
ASCO Annual Meeting 2018
Related Report
Int'l Joint Research
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