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Practice of holistic medicine for multifaceted assessment and longitudinal treatment of frailty in oral cancer patients

Research Project

Project/Area Number 18K09749
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionKagoshima University

Principal Investigator

Suzuki Hajime  鹿児島大学, 医歯学域歯学系, 助教 (10623340)

Co-Investigator(Kenkyū-buntansha) 石畑 清秀  鹿児島大学, 医歯学域鹿児島大学病院, 講師 (10437957)
吉村 卓也  鹿児島大学, 医歯学域鹿児島大学病院, 助教 (30726758)
改元 香  鹿児島女子短期大学, その他部局等, 講師 (50649861)
手塚 征宏  鹿児島大学, 医歯学域歯学系, 助教 (50759777)
中村 典史  鹿児島大学, 医歯学域歯学系, 教授 (60217875)
網谷 東方  鹿児島大学, 医歯学域鹿児島大学病院, 講師 (70535674)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords口腔がん / サルコペニア / 栄養 / フレイル / 画像評価 / 診療連携手帳 / 摂食嚥下障害 / 骨格筋の量と質 / 口腔癌 / CT / 医科歯科連携
Outline of Final Research Achievements

The number of elderly cancer patients is increasing every year, and many reports indicate that the presence of frailty and sarcopenia leads to an increased risk of postoperative complications and adverse effects of chemoradiation therapy, as well as an increased risk of death. There are few reports on the actual status of frailty and sarcopenia in oral cancer patients, and its impact on life expectancy remains unclear. In our retrospective study of oral cancer patients, we found decreased survival in patients with preoperative lumbar skeletal muscle mass and skeletal muscle adiposity (decreased skeletal muscle quality). In addition, we found that preoperative low nutrition and the presence of poor skeletal muscle quality were independent risk factors for life expectancy.

Academic Significance and Societal Importance of the Research Achievements

本研究により、口腔がん患者の生命予後に、術前の栄養障害とサルコペニアが強く関係していることを見出し、高齢者におけるフレイル・サルコペニア予防の重要性が明らかとなった。このことは、高齢がん治療において、生命予後のみならず、高齢者の脆弱性に焦点を当てた、総合的・多角的な評価を取り入れ、治療選択を行うことの重要性を示唆している。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] Impact of Preoperative Low Prognostic Nutritional Index and High Intramuscular Adipose Tissue Content on Outcomes of Patients with Oral Squamous Cell Carcinoma2020

    • Author(s)
      Yoshimura T, Suzuki H, Takayama H, Higashi S, Hirano Y, Tezuka M, Ishida T, Ishihata K, Nishi Y, Nakamura Y, Imamura Y, Nozoe E, Nakamura N
    • Journal Title

      Cancers

      Volume: 12 Issue: 11 Pages: 3167-3167

    • DOI

      10.3390/cancers12113167

    • NAID

      130008076348

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 口腔癌患者における体組成評価の有用性の検討2019

    • Author(s)
      吉村卓也, 鈴木 甫, 手塚征宏, 石田喬之, 渕上貴央, 東翔太朗, 野添悦郎, 中村典史
    • Organizer
      第37回日本口腔腫瘍学会総会・学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 口腔癌患者において術前低栄養と心理的苦痛の程度は関係する2019

    • Author(s)
      鈴木 甫, 吉村卓也, 手塚征宏, 東翔太朗, 渕上貴央, 小野裕右, 石田喬之, 石畑清秀, 野添悦郎, 中村典史
    • Organizer
      第64回日本口腔外科学会総会・学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 口腔癌患者における頸部筋肉評価の有用性2019

    • Author(s)
      吉村卓也, 鈴木 甫, 手塚征宏, 石田喬之, 東翔太朗, 渕上貴央, 小野裕右, 石畑清秀, 野添悦郎, 中村典史
    • Organizer
      第64回日本口腔外科学会総会・学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 口腔癌患者における体組成評価の有用性の検討2018

    • Author(s)
      吉村卓也, 鈴木 甫, 手塚征宏, 渕上貴央, 東 翔太朗, 石畑清秀, 中村典史
    • Organizer
      第42回日本頭頸部癌学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Sarcopenia and prognosis in oral cancer patients2018

    • Author(s)
      Yoshimura T, Suzuki H, Tezuka M, Ishida T, Nozoe E, Nakamura N
    • Organizer
      第63回日本口腔外科学会総会・学術総会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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