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Standardization of the assessment of the depth of invasion in oral cancer using intraoral ultrasonography

Research Project

Project/Area Number 18K09763
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionNiigata University

Principal Investigator

Hayashi Takafumi  新潟大学, 医歯学系, 教授 (80198845)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords口腔癌 / 舌癌 / 深達度 / DOI / 超音波診断 / 口腔内走査 / 音響カップリング材 / 標準化 / 扁平上皮癌 / 口腔内超音波診断 / 浸潤深度 / 浸潤
Outline of Final Research Achievements

In current TNM classification (8th edition) of oral cavity cancer, depth of invasion (DOI) has been incorporated into T staging. DOI is defined as the depth of tumor by dropping a “plumb line” to the deepest portion of the tumor from the level of the basement membrane of the normal mucosa closest to the tumor. Based on those retrospective single-institutional and multi-institutional studies including a comparative study using CT and MRI, it was suggested that intraoral ultrasonography with acoustic coupling polymer gel could be a promising method for the measurement of DOI in T1/T2 tongue squamous cell carcinoma with a sufficient accuracy.

Academic Significance and Societal Importance of the Research Achievements

口腔癌の予後を規定する頸部領域リンパ節転移に、原発巣の深達度が関連するとされている。本研究により、T1・T2の舌扁平上皮癌の深達度(Depth of invasion: DOI)の計測において、音響カップリング材を併用した口腔内超音波診断法に高い有用性が認められ、病理組織学的DOIと比較した場合にその診断精度はCTやMRIを凌駕していることが明らかとなった。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (15 results)

All 2022 2021 2019 2018 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (3 results) Remarks (1 results)

  • [Journal Article] A phantom study regarding the formation mechanism of mucosal epithelial echo on intraoral ultrasonography2022

    • Author(s)
      Kobayashi Taichi、Hayashi Takafumi、Takamura Masaki、Soga Marie、Nikkuni Yutaka、Katsura Kouji
    • Journal Title

      Oral Science International

      Volume: - Issue: 3 Pages: 147-153

    • DOI

      10.1002/osi2.1129

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A comparative study between CT, MRI, and intraoral US for the evaluation of the depth of invasion in early stage (T1/T2) tongue squamous cell carcinoma2021

    • Author(s)
      Takamura Masaki、Kobayashi Taichi、Nikkuni Yutaka、Katsura Kouji、Yamazaki Manabu、Maruyama Satoshi、Tanuma Jun-ichi、Hayashi Takafumi
    • Journal Title

      Oral Radiology

      Volume: 38 Issue: 1 Pages: 114-125

    • DOI

      10.1007/s11282-021-00533-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regarding the acoustic coupling medium for the estimation of the depth of invasion in tongue squamous cell carcinoma on intraoral sonography with special reference to the interpretation of normal mucosal structure: A literature review2021

    • Author(s)
      Hayashi Takafumi、Takamura Masaki、Kobayashi Taichi、Nikkuni Yutaka、Katsura Kouji
    • Journal Title

      Oral Science International

      Volume: - Issue: 1 Pages: 19-23

    • DOI

      10.1002/osi2.1110

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 顎口腔・歯科領域の画像診断と放射線治療2019

    • Author(s)
      林 孝文,小林太一,髙村真貴,曽我麻里恵,新國 農,勝良剛詞
    • Journal Title

      臨床画像

      Volume: 35 Pages: 387-391

    • Related Report
      2019 Research-status Report
  • [Presentation] A comparative study between CT, MRI, and intraoral us for the evaluation of the depth of invasion in early stage (T1/T2) tongue squamous cell carcinoma2021

    • Author(s)
      Takamura M, Kobayashi T, Nikkuni Y, Katsura K, Yamazaki M, Maruyama S, Tanuma J, Hayashi T
    • Organizer
      The 23rd International Congress of DentoMaxilloFacial Radiology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 共同研究委員会WG3 (口腔癌DOIの画像評価)の進捗報告2021

    • Author(s)
      小林太一,林 孝文,田沼順一,小椋一朗,岡田康男,湯浅賢治,白石朋子,有地淑子,杉田好彦,富岡寛文,小西 勝
    • Organizer
      第39回日本口腔腫瘍学会総会・学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 口腔顎顔面領域の超音波診断の現状と将来2019

    • Author(s)
      林 孝文
    • Organizer
      第73回NPO法人日本口腔科学会学術集会
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Invited
  • [Presentation] 高分子ゲル音響カップリング材を併用した舌癌の口腔内超音波検査による深達度計測2019

    • Author(s)
      林 孝文,曽我麻里恵,小林太一,髙村真貴,新國 農,勝良剛詞,丸山 智,田沼順一
    • Organizer
      日本超音波医学会第92回学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Accuracy of intraoral sonography in measurement of depth of invasion in superficial tongue carcinoma2019

    • Author(s)
      Hayashi T, Takamura M, Kobayashi T, Nikkuni Y, Katsura K, Maruyama S, Yamazaki M, Tanuma J
    • Organizer
      22nd International Congress of Dental and Maxillofacial Radiology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口腔癌の診断基準~画像診断の立場から2019

    • Author(s)
      林 孝文
    • Organizer
      第64回日本口腔外科学会総会・学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 口腔内超音波走査における粘膜上皮層に関するファントムを用いた基礎的検討2018

    • Author(s)
      小林太一,林 孝文,池真樹子,新國 農,勝良剛詞,西山秀昌,田中 礼
    • Organizer
      第72回NPO法人日本口腔科学会学術集会
    • Related Report
      2018 Research-status Report
  • [Book] 口腔癌診療ガイドライン2019年版2019

    • Author(s)
      足立雅利,太田嘉英,大鶴 洋,桐田忠昭,楠川仁悟,栗田 浩,後藤 温,佐々木朗,佐藤一道,仙波伊知郎,高橋浩二,中山英二,野村武史,林 孝文,林 隆一,原田浩之,藤原崇志,不破信和,三浦雅彦,柳下寿郎,相原守夫,湯浅秀道
    • Total Pages
      253
    • Publisher
      金原出版
    • ISBN
      9784307450140
    • Related Report
      2019 Research-status Report
  • [Book] 歯科臨床画像診断のチェックポイント2019

    • Author(s)
      林 孝文,髙村真貴,小林太一,曽我麻里恵,新國 農,勝良剛詞,田中 礼.勝又明敏,神部芳則
    • Total Pages
      161
    • Publisher
      医歯薬出版
    • ISBN
      9784263461570
    • Related Report
      2019 Research-status Report
  • [Book] 口腔癌取扱い規約[第2版]2019

    • Author(s)
      太田嘉英,野口忠秀,長塚 仁,有地榮一郎,上田倫弘,鵜澤成一,大倉正也,桐田忠昭,林 孝文,林 隆一,伏見千宙,不破信和,本間義崇,三浦雅彦,森 泰昌,柳下寿郎,八木原一博,柳本惣市,山城正司,原田浩之,長谷川和樹
    • Total Pages
      170
    • Publisher
      金原出版
    • ISBN
      9784307450133
    • Related Report
      2018 Research-status Report
  • [Remarks] 臨床研究:舌癌深達度エコー評価基準の策定

    • URL

      https://www5.dent.niigata-u.ac.jp/~radiology/hayashi/research/

    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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