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Elucidation of the pathophysiology and cause of progressive mandibular condylar resorption

Research Project

Project/Area Number 18K09764
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionKanazawa University

Principal Investigator

Ooi Kazuhiro  金沢大学, 附属病院, 講師 (90451450)

Co-Investigator(Kenkyū-buntansha) 中村 博幸  琉球大学, 大学院医学研究科, 教授 (30542253)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Discontinued (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords進行性下顎頭吸収 / STR/ortマウス / STR/Ortマウス / -1AlaTIMP3 / STR / Ortマウス / TMJ-OA / アグリカナーゼ / [-1A] TIMP-3 / 下顎頭軟骨 / 保護 / 野生型Str/Ortマウス / 病態 / 発症原因
Outline of Final Research Achievements

We studied the pathophysiology and elucidation of the cause of progressive mandibular resorption. Progressive mandibular resorption (PCR) is an acquired disease in which progressive mandibular resorption of unknown cause and the accompanying marked decrease in volume of the same part occur in a short period of time. In this study, we analyzed the mechanism of mandibular resorption using STR / ort mice that spontaneously develop mandibular resorption similar to PCR. Mandibular condyle absorption progressed in the mandibular condyle of STR / ort mice due to aging, and absorption was more advanced in females than in males. This phenomenon is similar to that of humans, suggesting that it may be useful as an animal model for human PCR studies. It was also suggested that -1AlaTIMP3 may suppress cartilage destruction in STR / ort mice.

Academic Significance and Societal Importance of the Research Achievements

進行性下顎頭吸収は両側性に生じ、15から35歳の女性に好発することが知られているが、病態や発症原因は明らかになっていない。下顎頭の吸収により下顎枝高径の短縮、下顎の後退や下顎の時計回りの回転による開咬が生じ、咀嚼・構音・呼吸などの機能障害を招く。現在のところ有効な治療や予防法は確立されておらず、主に顎骨の骨切りを併用した外科的矯正治療が行われているのみである。本研究成果は、STR/ortマウスが進行性下顎頭吸収の動物モデルとして有用な可能性、-1AlaTIMP3が下顎頭吸収を抑制する可能性を示唆しており、今後の病態解明に貢献すると考えられる。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2021 2019 Other

All Int'l Joint Research (4 results) Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] University of Liverpool(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Aging and chronic diesase/University of Liverpool(英国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Translational medicine/University of Liverpool(英国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] リバプール大学(英国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Metalloelastase-12 is involved in the temporomandibular joint inflammatory response as well as cartilage degradation by aggrecanases in STR/Ort mice2021

    • Author(s)
      Yamashita-futani Yoko、Jokaji Rei、Ooi Kazuhiro、Kobayashi Kazuhiko、Kanakis Ioannis、Liu Ke、Kawashiri Shuichi、Bou-gharios George、Nakamura Hiroyuki
    • Journal Title

      Biomedical Reports

      Volume: 14 Issue: 6 Pages: 1-8

    • DOI

      10.3892/br.2021.1427

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] Temporomandibular joint osteoarthritis in the STR/Ort mouse model of spontaneous osteoarthritis and effect of targeted inhibition of aggrecanases for mandibular condylar cartilage degradation2019

    • Author(s)
      Kazuhiro Ooi, Ioannis Kanakis, Yoko Yamashita, Hiroyuki Nakamura, Shuichi Kawashiri, George Bou-Gharios
    • Organizer
      American Society for Temporomandibular Joint Surgeon Meeting 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of targeted inhibition of aggrecanases for mandibular condylar cartilage degradation in the STR/Ort spontaneous mouse model of temporomandibular joint osteoarthritis2019

    • Author(s)
      OOI K, KANAKIS I, YAMASHITA Y, IDE K, FUTANI Y, KOBAYASHI Y, KOBAYASHI K, JOKAJI R, NAKAMURA H, YAMAMOTO K, SAKAI T, BOU-GHARIOS G, KAWASHIRI S
    • Organizer
      The 6th Asian Academy congress for TMJ
    • Related Report
      2019 Research-status Report
  • [Funded Workshop] American Society of TMJ Surgeons2019

    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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