Comprehensive evaluation of diffusion information using statistical model and pharmacokinetic analysisApplication to the head and neck

• Project/Area Number: 18K09770
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Kyushu University
• Principal Investigator: Toru Chikui 九州大学, 歯学研究院, 准教授 (10295090)
• Co-Investigator(Kenkyū-buntansha): 川野 真太郎 九州大学, 大学病院, 講師 (00398067) ; 吉浦 一紀 九州大学, 歯学研究院, 教授 (20210643) ; 北本 江梨奈 九州大学, 歯学研究院, 助教 (40760476) ; 山下 泰生 九州大学, 大学病院, 診療放射線技師 (70380516)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: MRI / 拡散強調画像 / ダイナミック撮像 / 薬物動態モデル / 拡散強調像 / 薬物動体モデル / ダイナミックMRI / 組織灌流 / 薬物動態解析 / 拡散係数 / non-Gaussian分布 / gamma distribution model / ガンマ分布 / 統計学的モデル / 頭頸部

Outline of Final Research Achievements

In the analysis of diffusion-weighted images of the maxillofacial area, it was possible to clarify the characteristics of lesions in the maxillofacial area using the monoexponential model, IVIM model, and gamma distribution model. Parameters derived from the gamma distribution were considered to reflect pathology. In addition, it was found that there is a good correlation with the parameters of I V I M, and that there is a complementary relationship.
From pharmacokinetic analysis based on dynamic imaging and model analysis of diffusion-weighted images, the ratio of cells and stroma correlated with diffusion in vivo. Correlation was found in parameters related to blood flow information, but the correlation coefficient was not very high. From this, it was considered necessary to consider the results of each of the two imaging methods as diagnostic criteria.

Academic Significance and Societal Importance of the Research Achievements

拡散強調画像は、広く使われているが、高いb値を設定しにくい顎顔面部では複雑なモデルは使用できない。そのような制限の中で利用できるガンマ分布モデルの診断学的な有用性を示した事は、重要な意義があったと考える。さらにダイナミック撮像の薬物動態モデル解析と拡散強調像のモデル解析との結果を比較した研究は、顎顔面部では皆無であったために、有意義な結果を得たものと考えている。

Research Products

• [Journal Article] A comparison among gamma distribution, intravoxel incoherent motion, and mono-exponential models with turbo spin-echo diffusion-weighted MR imaging in the differential diagnosis of orofacial lesions (2022)
  • Author(s): Wannakamon Panyarak , Toru Chikui , Kenji Tokumori , Yasuo Yamashita, Takeshi Kamitani, Osamu Togao , Shintaro Kawano, Kazunori Yoshiura
  • Journal Title: Dentomaxillofac Radiol Volume: 51(1) Issue: 1 Pages: 20200609-20200609
  • DOI: 10.1259/dmfr.20200609
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The application of a gamma distribution model to diffusion-weighted images of the orofacial region (2021)
  • Author(s): Chikui, T., Tokumori, K., Panyarak, W., Togao, O., Yamashita, Y., Kawano, S., Kamitani, T., Yoshiura, K.
  • Journal Title: Dentomaxillofacial Radiology Volume: 50(2) Issue: 2 Pages: 20200252-20200252
  • DOI: 10.1259/dmfr.20200252
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Utility of a diffusion kurtosis model in the differential diagnosis of orofacial tumours (2020)
  • Author(s): Panyarak W.、Chikui T.、Tokumori K.、Yamashita Y.、Kamitani T.、Togao O.、Yoshiura K.
  • Journal Title: Clinical Radiology Volume: in press Issue: 7 Pages: 507-519
  • DOI: 10.1016/j.crad.2020.01.008
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Correlation between diffusion-derived parameters and pharmacokinetic parameters based on dynamic contrast enhanced MR imaging (2022)
  • Author(s): Toru Chikui, Masahiro Ohga, Yukiko Kami, Kazutoshi Okamura, Osamu Togao, Kazunori Yoshiura.
  • Organizer: 第62回学術大会・第18回定例総会 第13回アジア口腔顎顔面放射線学会
  • Int'l Joint Research
• [Presentation] 顎顔面部MRI 画像の定量化 -組織パラメータから病変を考察する- (2022)
  • Author(s): 筑井 徹
  • Organizer: 全国歯科大学・歯学部附属病院診療放射線技師連絡協議会2022年度歯科放射線技術研修会
  • Invited
• [Presentation] A comparison among gamma distribution, intravoxel incoherent motion, and mono-exponential models of orofacial tumours: a preliminary stu (2020)
  • Author(s): Panyarak Wannakamon, Chikui Toru, Tokumori Kenji, Yamashita Yasuo, Yoshiura Kazunori
  • Organizer: ECR2020
  • Int'l Joint Research
• [Presentation] Comparision among mono-exponential, IVIM, and gamma distribution models of orafacial tumors: A preliminary study (2019)
  • Author(s): Wannakamon Panyarak, 筑井徹, 徳森謙二, 山下泰生, 吉浦一紀
  • Organizer: 日本歯科放射線学会第60回学会学術大会
• [Presentation] 顔面部拡散強調画像における簡易IVIMの有用性の検討 (2019)
  • Author(s): 筑井徹, Wannakamon Panyarak, 山下泰生, 川野真太郎, 吉浦一紀
  • Organizer: 日本歯科放射線学会第60回学会学術大会
• [Presentation] 顔面部拡散強調画像におけるGamma distribution modelの有用性の検討 (2019)
  • Author(s): 筑井徹, 徳森謙二, Wannakamon Panyarak, 山下泰生, 吉浦一紀
  • Organizer: 日本歯科放射線学会第60回学会学術大会
• [Presentation] 顎顔面部腫瘍の拡散強調画像に対するガンマ分布モデル法および簡易IVIM法の応用 (2019)
  • Author(s): 筑井徹, 徳森謙二, Wannakamon Panyarak, 山下泰生, 神谷武志, 栂尾理, 吉浦一紀
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] Utility of diffusion kurtosis model in differential diagnosis of orofacial tumors (2019)
  • Author(s): Wannakamon Panyarak, Toru Chikui, Kenji Tokumori, Yasuo Yamashita, Kazunori Yoshiura
  • Organizer: 第47回日本磁気共鳴医学会大会