Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
The present study focused on radiation resistance of high-grade oral cancer, especially oral squamous cell carcinoma (OSCC) cells. The exosomes secreted by the radiation-resistant OSCC cell line (SAS-R) established from the OSCC cell line SAS confer radioresistant phenotype on SAS and HSC2 through BAK regulation by the contained miR-503-3p and apoptosis suppression . In addition, as a result of analysis using patient's serum, it was clarified that the expression of miR-503-3p in blood correlates with the pathological response to chemoradiotherapy and the patient prognosis. The mechanism of radiation resistance acquisition was clarified
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