Revealing the prognostic marker microRNA of delayed regional lymph node metastasis in oral cancer via the oral brush biopsy system
| Project/Area Number |
18K09773
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Arasaki Akira 琉球大学, 熱帯生物圏研究センター, 協力研究員 (00175960)
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| Co-Investigator(Kenkyū-buntansha) |
海川 正人 琉球大学, 医学(系)研究科(研究院), 准教授 (00325838)
丸山 哲昇 琉球大学, 熱帯生物圏研究センター, 協力研究員 (60751493)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 口腔がん / 扁平上皮癌 / マイクロRNA / brush biopsy / 口腔癌 / 後発頸部リンパ節転移 / 予測マーカー / 口腔擦過細胞診 / microRNA / 頸部リンパ節転移 |
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| Outline of Final Research Achievements |
Oral squamous cell carcinoma (OSCC) is one of the most common malignancies with a high mortality rate. Delayed regional lymph node metastasis is the reason for the high mortality rate of OSCC. To evaluate the mechanism of OSCC, we analyzed human oral epithelium cells and in vitro cell lines and subsequently published an article on OSCC-related microRNA and the target gene.
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| Academic Significance and Societal Importance of the Research Achievements |
口腔がんは、適切に治療しても、後になって再発・転移をしやすいため、死亡率の高いがんといわれます。その再発・転移の機序を解明することが、診断・治療の発展につながり、がんによる死亡率を減らすことが期待できます。本研究では、口腔がんに関係するマイクロRNAという核酸を対象としてます。このマイクロRNAの更なる研究により、口腔がんの制御のヒントを探索してゆきます。
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Early computed tomography for detection of internal jugular vein thrombosis after neck dissection and/or reconstruction surgery for head and neck cancer patients.2019
Author(s)
Maruyama N, Shimizu Y, Nakaema M, Nishihara K, Nakasone T, Matsumoto H, Kusada T, Nimura F, Matayoshi A, Maruyama T, Yoshimi N, Arasaki A.
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Journal Title
International Journal of Clinical and Experimental Medicine
Volume: 12
Pages: 6258-6266
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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