• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Revealing the prognostic marker microRNA of delayed regional lymph node metastasis in oral cancer via the oral brush biopsy system

Research Project

Project/Area Number 18K09773
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionUniversity of the Ryukyus

Principal Investigator

Arasaki Akira  琉球大学, 熱帯生物圏研究センター, 協力研究員 (00175960)

Co-Investigator(Kenkyū-buntansha) 海川 正人  琉球大学, 医学(系)研究科(研究院), 准教授 (00325838)
丸山 哲昇  琉球大学, 熱帯生物圏研究センター, 協力研究員 (60751493)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords口腔がん / 扁平上皮癌 / マイクロRNA / brush biopsy / 口腔癌 / 後発頸部リンパ節転移 / 予測マーカー / 口腔擦過細胞診 / microRNA / 頸部リンパ節転移
Outline of Final Research Achievements

Oral squamous cell carcinoma (OSCC) is one of the most common malignancies with a high mortality rate. Delayed regional lymph node metastasis is the reason for the high mortality rate of OSCC. To evaluate the mechanism of OSCC, we analyzed human oral epithelium cells and in vitro cell lines and subsequently published an article on OSCC-related microRNA and the target gene.

Academic Significance and Societal Importance of the Research Achievements

口腔がんは、適切に治療しても、後になって再発・転移をしやすいため、死亡率の高いがんといわれます。その再発・転移の機序を解明することが、診断・治療の発展につながり、がんによる死亡率を減らすことが期待できます。本研究では、口腔がんに関係するマイクロRNAという核酸を対象としてます。このマイクロRNAの更なる研究により、口腔がんの制御のヒントを探索してゆきます。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2020 2019

All Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 6 results)

  • [Journal Article] miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol Polyphosphate-4-phosphatase Type IA (INPP4A)2020

    • Author(s)
      Nobuyuki Maruyama
    • Journal Title

      Anticancer Research

      Volume: 40(11) Issue: 11 Pages: 6101-6113

    • DOI

      10.21873/anticanres.14631

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral health behavior of children and guardians’ beliefs about children’s dental caries in Vientiane, Lao People’s Democratic Republic (Lao PDR)2019

    • Author(s)
      Phanthavong Somphone、Nonaka Daisuke、Phonaphone Thongsavanh、Kanda Kyoko、Sombouaphan Phouphachanh、Wake Norie、Sayavong Sangvane、Nakasone Toshiyuki、Phongsavath Khampe、Arasaki Akira
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 1 Pages: 1-10

    • DOI

      10.1371/journal.pone.0211257

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thymoma appearing 9 years after resection of lip squamous cell carcinoma: a case report of triple primary tumors and literature review.2019

    • Author(s)
      Maruyama N, Sasaki T, Arasaki A, et al.
    • Journal Title

      Oncology Letters

      Volume: 18 Pages: 2777-2788

    • DOI

      10.3892/ol.2019.10675

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Early computed tomography for detection of internal jugular vein thrombosis after neck dissection and/or reconstruction surgery for head and neck cancer patients.2019

    • Author(s)
      Maruyama N, Shimizu Y, Nakaema M, Nishihara K, Nakasone T, Matsumoto H, Kusada T, Nimura F, Matayoshi A, Maruyama T, Yoshimi N, Arasaki A.
    • Journal Title

      International Journal of Clinical and Experimental Medicine

      Volume: 12 Pages: 6258-6266

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] K1 gene transformation activities in AIDS-related and classic type Kaposi’s sarcoma: Correlation with clinical presentation2019

    • Author(s)
      Tamanaha-Nakasone Ayumi、Uehara Karina、Tanabe Yasuka、Ishikawa Haruna、Yamakawa Natsuko、Toyoda Zensei、Kurima Kiyoto、Kina Shinichiro、Tsuneki Masayuki、Okubo Yuko、Yamaguchi Sayaka、Utsumi Daisuke、Takahashi Kenzo、Arakawa Hirofumi、Arasaki Akira、Kinjo Takao
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-019-42763-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 進行舌癌治療後に発症した治療関連骨髄異形成症候群の1例.2019

    • Author(s)
      仁村文和, 丸山哲昇, 村橋信, 丸山修幸, 新崎章.
    • Journal Title

      日本口腔腫瘍学会誌

      Volume: 31 Issue: 2 Pages: 91-96

    • DOI

      10.5843/jsot.31.91

    • NAID

      130007666288

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi