| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Emerging evidence suggests that oral microbiota-derived short-chain fatty acids (SFCAs) are important modulators of pathogenesis of chronic obstructive pulmonary disease (COPD). However, it was unclear how periodontitis induces COPD. Therefore, we examined whether SCFAs modulates human airway smooth muscle tone through short chain fatty acid receptor FFAR3, and its intracellular mechanisms. Activation of FFAR3 in human airway smooth muscle with SCFAs potentiated acetylcholine-induced human airway smooth muscle contraction through the reduction of cAMP production and the increase in intracellular calcium.
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