micro cancer detection by reaction of metabolism

• Project/Area Number: 18K09786
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Shinshu University
• Principal Investigator: SHIMANE Tetsu 信州大学, 医学部附属病院, 特任研究員 (80714469)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: アミノ酸代謝 / 抗がん剤 / 口腔がん / がん / 癌細胞 / メタボローム解析 / 癌の代謝 / 化学療法抵抗性 / 微小転移 / 解糖系 / 外科的断端 / GGT / 癌細胞の代謝 / 術中診断

Outline of Final Research Achievements

It has been previously reported that in cancer cells, glucose metabolism is biased toward anaerobic metabolism. Our research so far has focused on amino acid metabolism. We examined the residual cancer cells during surgery. We succeeded in detecting cancer cells left in the tissue.
We also clarified the metabolism of cancer cells and clarified that the sensitivity of anticancer drugs is changed by blocking some pathways of amino acid metabolism.

Academic Significance and Societal Importance of the Research Achievements

がん細胞特有のアミノ酸代謝を複数経路見出すことができた。また、その経路を遮断することにより抗がん剤への感受性が変化した。がん治療の中で化学療法を行う際には特殊な条件を設定することにより抗がん剤の効果を増大させたり、副作用低減させたり可能性が示唆された。

Research Products

• [Journal Article] Correlations between the properties of saliva and metabolic syndrome: A prospective observational study (2020)
  • Author(s): Daisuke Suzuki , Shin-Ichi Yamada, Akinari Sakurai, Imahito Karasawa, Eiji Kondo, Hironori Sakai, Hirokazu Tanaka, Tetsu Shimane, Hiroshi Kurita
  • Journal Title: Medicine (Baltimore) Volume: 99(51)
  • Peer Reviewed
• [Journal Article] Effects of a micro-thread at the implant neck on securing the quantity and quality of bone formation around implants (2019)
  • Author(s): Yinghui Li, Shin-ichi Yamada , Hitoshi Aizawa, Fangfang Qi, Tetsu Shimane, Masafumi Morioka, Hiroshi Kurita
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: 31 Pages: 13-19
  • Peer Reviewed