Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
In addition to necrosis and apoptosis, cell death is mediated by autophagy. Treatment of human oral squamous cell carcinoma cells with PF-543 induced necrosis, apoptosis and autophagy, and the combination of PF-543 and autophagy inhibitor enhanced cell death more than PF-543 alone, suggesting that autophagy may play a role in cell survival. Research on inhibitors of SphK is ongoing, and further development of molecular targeted therapy targeting SphK is expected through the development of new drugs and elucidation of their mechanisms of action.
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