Regulation of the biological character of cancer and induction of cancer by the cancer stroma.

• Project/Area Number: 18K09789
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Okayama University
• Principal Investigator: Nakano Keisuke 岡山大学, 医歯薬学域, 准教授 (10325095)
• Co-Investigator(Kenkyū-buntansha): 長塚 仁 岡山大学, 医歯薬学域, 教授 (70237535) ; 高畠 清文 岡山大学, 医歯薬学域, 助教 (70736537) ; 河合 穂高 岡山大学, 医歯薬学域, 助教 (10803687) ; 江口 傑徳 岡山大学, 医歯薬学域, 講師 (20457229) ; 辻極 秀次 岡山理科大学, 理学部, 教授 (70335628) ; 志茂 剛 北海道医療大学, 歯学部, 教授 (40362991)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 口腔癌 / 扁平上皮癌 / 腫瘍間質 / 生物学的性格 / 癌間質 / 癌化 / 相互作用 / 腫瘍微小環境 / オルガノイド / 組織型

Outline of Final Research Achievements

The purpose of this study is to verify that the stroma of oral cancer can act on cancer cells to alter their biological properties and that the tumor stroma can act on the normal cells surrounding the cancer to cause tumorigenesis. The effects of the combination of oral squamous cell carcinoma cell lines and stromal cells in culture and tumor stroma on the biological character of tumor cells (proliferative capacity, invasive capacity, migratory capacity, and morphology) were examined histopathologically. The results showed that tumor tissues significantly change their properties depending on differences in tumor stroma. The results of this study strongly support that cancer stroma directly modulates the biological character of cancer.

Academic Significance and Societal Importance of the Research Achievements

本研究結果は、癌間質が直接的に癌の生物学的性格を調節していることを強く裏付けるものである。この研究結果は癌間質に注目した癌の治療戦略に結び付く非常に重要な成果である。本研究結果は間質により腫瘍細胞の性質の制御を行い得る可能性を示しており、腫瘍間質を腫瘍の主要な構成成分と見立てた新しい治療法の開発に繋がる。さらに、腫瘍切除時の適切な切除範囲の基準をもたらす可能性を含んでいる。

Research Products

• [Journal Article] Crosstalk between cancer and different cancer stroma subtypes promotes the infiltration of tumor associated macrophages into the tumor microenvironment of oral squamous cell carcinoma (2022)
  • Author(s): Shan Qiusheng、Takabatake Kiyofumi、Kawai Hotaka、Oo May、Sukegawa Shintaro、Fujii Masae、Nakano Keisuke、Nagatsuka Hitoshi
  • Journal Title: International Journal of Oncology Volume: 60 Issue: 6 Pages: 1-10
  • DOI: 10.3892/ijo.2022.5368
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment (2022)
  • Author(s): Oo May Wathone、Kawai Hotaka、Takabatake Kiyofumi、Tomida Shuta、Eguchi Takanori、Ono Kisho、Shan Qiusheng、Ohara Toshiaki、Yoshida Saori、Omori Haruka、Sukegawa Shintaro、Nakano Keisuke、Okamoto Kuniaki、Sasaki Akira、Nagatsuka Hitoshi
  • Journal Title: JCI Insight Volume: 7 Issue: 1 Pages: 1-10
  • DOI: 10.1172/jci.insight.148960
  • NAID: 120007186650
  • Peer Reviewed / Open Access
• [Journal Article] Cancer-Associated Stromal Cells Promote the Contribution of MMP2-Positive Bone Marrow-Derived Cells to Oral Squamous Cell Carcinoma Invasion (2021)
  • Author(s): Oo May Wathone、Kawai Hotaka、Takabatake Kiyofumi、Shan Qiusheng、Eain Htoo Shwe、Sukegawa Shintaro、Nakano Keisuke、Nagatsuka Hitoshi
  • Journal Title: Cancers Volume: 14 Issue: 1 Pages: 137-137
  • DOI: 10.3390/cancers14010137
  • NAID: 120007185107
  • Peer Reviewed / Open Access
• [Journal Article] Comparing the Osteogenic Potential and Bone Regeneration Capacities of Dedifferentiated Fat Cells and Adipose-Derived Stem Cells In Vitro and In Vivo: Application of DFAT Cells Isolated by a Mesh Method (2021)
  • Author(s): Kiyofumi Takabatake , Masakazu Matsubara , Eiki Yamachika, Yuki Fujita, Yuki Arimura, Kazuki Nakatsuji , Keisuke Nakano , Histoshi Nagatsuka , Seiji Iida
  • Journal Title: Int J Mol Sci . Volume: 22 Issue: 22 Pages: 12392-12392
  • DOI: 10.3390/ijms222212392
  • NAID: 120007175399
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stromal cells in the tumor microenvironment promote the progression of oral squamous cell carcinoma (2021)
  • Author(s): Shan Qiusheng、Takabatake Kiyofumi、Omori Haruka、Kawai Hotaka、Oo May、Nakano Keisuke、Ibaragi Soichiro、Sasaki Akira、Nagatsuka Hitoshi
  • Journal Title: International Journal of Oncology Volume: 59 Issue: 3 Pages: 1-10
  • DOI: 10.3892/ijo.2021.5252
  • Peer Reviewed / Open Access
• [Journal Article] No convincing evidence for the presence of tubarial salivary glands: A letter to the editor regarding “The tubarial salivary glands: A potential new organ at risk for radiotherapy” (2021)
  • Author(s): Iwanaga Joe、Ibaragi Soichiro、Nakano Keisuke、Takeshita Yohei、Tubbs R. Shane
  • Journal Title: Radiotherapy and Oncology Volume: 154 Pages: 321-322
  • DOI: 10.1016/j.radonc.2020.12.007
• [Journal Article] 【免疫組織化学 実践的な診断・治療方針決定のために】(第3部)腫瘍の鑑別に用いられる抗体(各臓器別) 顎口腔領域 (2020)
  • Author(s): 中野 敬介, 長塚 仁
  • Journal Title: 病理と臨床 Volume: 38（2） Pages: 189-191
• [Journal Article] Wnt Signaling and Histological Characteristics of Odontogenic Tumors (2020)
  • Author(s): Keisuke Nakano, Kiyofumi Takabatake, Hotaka Kawai, Saori Yoshida, Hatsuhiko Maeda, Toshiyuki Kawakami, Hitoshi Nagatsuka
  • Journal Title: Diagn Pathol Open Volume: 5(1)
  • Peer Reviewed / Open Access
• [Journal Article] Schwannoma of Floor of the Mouth: A Case Report (2020)
  • Author(s): Haruka Omori1, Keisuke Nakano1, Yuki Nagata2, Kiyofumi Takabatake, Hotaka Kawai, Eiki Yamachika, Hitoshi Nagatsuka and Seiji Iida
  • Journal Title: Diagn Pathol Open Volume: 5(1)
  • Peer Reviewed / Open Access
• [Journal Article] Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report (2020)
  • Author(s): Takabatake Kiyofumi、Nakano Keisuke、Kawai Hotaka、Yoshida Saori、Omori Haruka、Wathone Oo May、Qiusheng Shan、Uchida Kenichiro、Mishima Katsuaki、Nagatsuka Hitoshi
  • Journal Title: Reports Medical Cases, Images, and Videos Volume: 3 Issue: 2 Pages: 6-6
  • DOI: 10.3390/reports3020006
  • NAID: 120007139733
  • Peer Reviewed / Open Access
• [Journal Article] 2 Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade. (2020)
  • Author(s): Hamada M, Ebihara Y, Nagata K, Yano M, Kogashiwa Y, Nakahira M, Sugasawa M, Nagatsuka H, Yasuda M.
  • Journal Title: Oncol Lett. Volume: 19 Pages: 2602-2608
  • DOI: 10.3892/ol.2020.11358
  • Peer Reviewed / Open Access
• [Journal Article] Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles (2020)
  • Author(s): Taha EA, Sogawa C, Okusha Y, Kawai H, Oo MW, Elseoudi A, Lu Y, Nagatsuka H, Kubota S, Satoh A, Okamoto K, and Eguchi T
  • Journal Title: Cancers (Basel). Volume: 12(5). Issue: 5 Pages: 1260-1260
  • DOI: 10.3390/cancers12051260
  • NAID: 120006864120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology (2020)
  • Author(s): Sukegawa Shintaro、Ono Sawako、Nakano Keisuke、Takabatake Kiyofumi、Kawai Hotaka、Nagatsuka Hitoshi、Furuki Yoshihiko
  • Journal Title: Diagnostic Pathology Volume: 15 Issue: 1 Pages: 107-107
  • DOI: 10.1186/s13000-020-01027-6
  • NAID: 120006890020
  • Peer Reviewed / Open Access
• [Journal Article] Impact of the Stroma on the Biological Characteristics of the Parenchyma in Oral Squamous Cell Carcinoma (2020)
  • Author(s): Takabatake Kiyofumi、Kawai Hotaka、Omori Haruka、Qiusheng Shan、Oo May Wathone、Sukegawa Shintaro、Nakano Keisuke、Tsujigiwa Hidetsugu、Nagatsuka Hitoshi
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 20 Pages: 7714-7714
  • DOI: 10.3390/ijms21207714
  • NAID: 120006900773
  • Peer Reviewed / Open Access
• [Journal Article] Homeobox transcription factor engrailed homeobox 1 is a possible diagnostic marker for adenoid cystic carcinoma and polymorphous adenocarcinoma (2020)
  • Author(s): Baba Shunichi、Akashi Takumi、Nakano Keisuke、Nagatsuka Hitoshi、Hasegawa Hiromasa、Ikeda Tohru
  • Journal Title: Pathology International Volume: 71 Issue: 2 Pages: 113-123
  • DOI: 10.1111/pin.13050
  • Peer Reviewed / Open Access
• [Journal Article] Notch Signaling Affects Oral Neoplasm Cell Differentiation and Acquisition of Tumor-Specific Characteristics (2019)
  • Author(s): Nakano Keisuke、Takabatake Kiyofumi、Kawai Hotaka、Yoshida Saori、Maeda Hatsuhiko、Kawakami Toshiyuki、Nagatsuka Hitoshi
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 8 Pages: 1973-1973
  • DOI: 10.3390/ijms20081973
  • NAID: 120006765095
  • Peer Reviewed / Open Access
• [Journal Article] Feasible Advantage of Bioactive/Bioresorbable Devices Made of Forged Composites of Hydroxyapatite Particles and Poly-L-lactide in Alveolar Bone Augmentation: A Preliminary Study (2019)
  • Author(s): Sukegawa Shintaro、Kawai Hotaka、Nakano Keisuke、Kanno Takahiro、Takabatake Kiyofumi、Nagatsuka Hitoshi、Furuki Yoshihiko
  • Journal Title: International Journal of Medical Sciences Volume: 16 Issue: 2 Pages: 311-317
  • DOI: 10.7150/ijms.27986
  • Peer Reviewed / Open Access
• [Journal Article] In Vivo Tissue Response of Endodontic Bio-ceramic Materials (2019)
  • Author(s): Romano Teresita、Jammal Maria Victoria、Nakano Keisuke、Rusco Ana Garcia、Fassi Jorge Olmos、Kozuszko Silvia、Takabatake Kiyofumi、Nagatsuka Hitoshi、Missana Liliana Raquel
  • Journal Title: Journal of Hard Tissue Biology Volume: 28 Issue: 1 Pages: 1-6
  • DOI: 10.2485/jhtb.28.1
  • NAID: 130007584511
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Biomechanical Loading Comparison between Titanium and Unsintered Hydroxyapatite/Poly-L-Lactide Plate System for Fixation of Mandibular Subcondylar Fractures (2019)
  • Author(s): Sukegawa Shintaro、Kanno Takahiro、Yamamoto Norio、Nakano Keisuke、Takabatake Kiyofumi、Kawai Hotaka、Nagatsuka Hitoshi、Furuki Yoshihiko
  • Journal Title: Materials Volume: 12 Issue: 9 Pages: 1557-1557
  • DOI: 10.3390/ma12091557
  • NAID: 120006816641
  • Peer Reviewed / Open Access
• [Journal Article] Immunohistochemistry of YAP and dNp63 and survival analysis of patients bearing precancerous lesion and oral squamous cell carcinoma (2019)
  • Author(s): Ono Sawako、Nakano Keisuke、Takabatake Kiyofumi、Kawai Hotaka、Nagatsuka Hitoshi
  • Journal Title: International Journal of Medical Sciences Volume: 16 Issue: 5 Pages: 766-773
  • DOI: 10.7150/ijms.29995
  • NAID: 120006860083
  • Peer Reviewed / Open Access
• [Journal Article] Tumor Angiogenic Inhibition Triggered Necrosis (TAITN) in Oral Cancer. (2019)
  • Author(s): Yoshida S, Kawai H, Eguchi T, Sukegawa S, Oo MW, Anqi C, Takabatake K, Nakano K, Okamoto K, Nagatsuka H.
  • Journal Title: Cells. Volume: 8(7). Issue: 7 Pages: 761-761
  • DOI: 10.3390/cells8070761
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Role of Sonic Hedgehog Signaling in the Tumor Microenvironment of Oral Squamous Cell Carcinoma (2019)
  • Author(s): Takabatake K, Shimo T, Murakami J, Anqi C, Kawai H, Yoshida S, Wathone Oo M, Haruka O, Sukegawa S, Tsujigiwa H, Nakano K, Nagatsuka H.
  • Journal Title: Int J Mol Sci Volume: 20(22) Issue: 22 Pages: 5779-5779
  • DOI: 10.3390/ijms20225779
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differentiation and roles of bone marrow-derived cells on the tumor microenvironment of oral squamous cell carcinoma (2019)
  • Author(s): Anqi C, Takabatake K, Kawai H, Oo MW, Yoshida S, Fujii M, Omori H, Sukegawa S, Nakano K, Tsujigiwa H, Jinhua Z, Nagatsuka H.
  • Journal Title: Oncol Lett Volume: 18(6) Pages: 6628-6638
  • DOI: 10.3892/ol.2019.11045
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An in vitro Three-Dimensional Co-Culture System for Ameloblastoma Modelling (2019)
  • Author(s): Lee Soo Leng、Abdul Rahman Zainal Ariff、Tsujigiwa Hidetsugu、Hamada Mei、Takabatake Kiyofumi、Nakano Keisuke、Nagatsuka Hitoshi、Chong Huat Siar
  • Journal Title: Sains Malaysiana Volume: 48 Issue: 8 Pages: 1697-1706
  • DOI: 10.17576/jsm-2019-4808-15
• [Journal Article] The role of bone marrow-derived cells during ectopic bone formation of mouse femoral muscle in GFP mouse bone marrow transplantation model. (2018)
  • Author(s): Takabatake K, Tsujigiwa H, Song Y, Matsuda H, Kawai H, Fujii M, Hamada M, Nakano K, Kawakami T and Nagatsuka H.
  • Journal Title: Int J Med Sci Volume: 15 Issue: 8 Pages: 748-757
  • DOI: 10.7150/ijms.24605
  • Peer Reviewed / Open Access
• [Journal Article] Significance of PD-L1 Expression in Tongue Cancer Development. (2018)
  • Author(s): Yoshida S, Nagatsuka H, Nakano K, Kogashiwa Y, Ebihara Y, Yano M, Yasuda M.
  • Journal Title: Int J Med Sci. 2018 Nov 22;15(14) Volume: 15 Issue: 14 Pages: 1723-1730
  • DOI: 10.7150/ijms.27860
  • Peer Reviewed / Open Access
• [Journal Article] Characterization and potential roles of bone marrow-derived stromal cells in cancer development and metastasis (2018)
  • Author(s): Kawai Hotaka、Tsujigiwa Hidetsugu、Siar Chong Huat、Nakano Keisuke、Takabatake Kiyofumi、Fujii Masae、Hamada Mei、Tamamura Ryo、Nagatsuka Hitoshi
  • Journal Title: International Journal of Medical Sciences Volume: 15 Issue: 12 Pages: 1406-1414
  • DOI: 10.7150/ijms.24370
  • Peer Reviewed / Open Access
• [Journal Article] Signaling Dynamics in Cell Differentiation of Pleomorphic Adenomas (2018)
  • Author(s): Yoshida W, Sugita Y, Isomura M, Kawai R, Kubo K, Maeda H, Ueda Y, Nakano K, Nagatsuka H, Kawakami T
  • Journal Title: J Dent Oral Health Volume: ４
  • Peer Reviewed / Open Access
• [Journal Article] 口腔と舌可動領域の腫瘍の分類と病理 (2018)
  • Author(s): 中野敬介，長塚 仁
  • Journal Title: 病理と臨床 Volume: 36 Pages: 211-215
  • Peer Reviewed
• [Presentation] CCL2-CCR2 axisを介した癌関連線維芽細胞による骨髄由来細胞の動員 (2021)
  • Author(s): 河合 穂高,、メイワトウ、高畠 清文、大森 悠加、中野 敬介、長塚 仁
  • Organizer: 第１１０回日本病理学会総会
• [Presentation] 口腔癌間質による癌の生物学的性格制御について (2021)
  • Author(s): 髙畠 清文
  • Organizer: 第３２回日本臨床口腔病理学会 学術大会
  • Invited
• [Presentation] Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment (2021)
  • Author(s): May wathone Oo , Hotaka Kawai , Kiyofumi Takabatake , Shuta Tomida , Takanori Eguchi , Htoo shwe Eain , Qiusheng Shan , Yasunori Inada , Keisuke Nakano and Hitoshi Nagatsuka
  • Organizer: 第３２回日本臨床口腔病理学会 学術大会
• [Presentation] 癌微小環境における口腔癌間質細胞と骨髄由来細胞の 関係性について (2021)
  • Author(s): 河合 穂高、 メイ ワト ウ、 高畠 清文、中野 敬介、長塚 仁
  • Organizer: 第６７回日本病理学会秋期特別総会
• [Presentation] Diagnosis criteria for oral epithelial dysplasia and carcinoma in situ according to general rules for clinical and pathological studies on oral cancer (2021)
  • Author(s): Hitoshi Nagatsuka
  • Organizer: The 12th Asia Pacific International Academy of Pathology Congress ＩＰＩＡＰ
  • Int'l Joint Research / Invited
• [Presentation] 口腔癌間質細胞が骨髄由来細胞の動員に与える影響 (2020)
  • Author(s): 河合 穂高, メイ・ワト ウ , 辻極 秀次, 高畠 清文, 大森 悠加, 藤井 昌江, 中野 敬介, 長塚 仁
  • Organizer: 第１０９回日本病理学会総会
• [Presentation] エナメル上皮腫開窓術の適応に関する組織学的検討 (2020)
  • Author(s): 大森 悠加, 高畠 清文, 河合 穂高, 吉田 沙織, メイ・ワト ウ , 浜田 芽衣, 中野 敬介, 長塚 仁
  • Organizer: 第１０９回日本病理学会総会
• [Presentation] 舌扁平上皮癌の浸潤様式(budding)におけるpodoplaninの関わり (2020)
  • Author(s): 浜田 芽衣, 蝦原 康宏, 永田 耕治, 矢野 光剛, 小柏 靖直, 中平 光彦, 菅澤 正, 長塚 仁, 安田 政実
  • Organizer: 第１０９回日本病理学会総会
• [Presentation] 口腔扁平上皮癌におけるCXCR4の腫瘍血管の役割 (2020)
  • Author(s): 大森 悠加, 河合 穂高, 吉田 沙織, 藤井 昌江, 単 秋生, 髙畠 清文, 中野 敬介, 長塚 仁
  • Organizer: 第３１回日本臨床口腔病理学会 学術大会
• [Presentation] 口腔扁平上皮癌における間質細胞か与える骨髄由来細胞の動員への影響 (2020)
  • Author(s): 河合 穂高, メイ ワト ウ, 髙畠 清文, 伏見 滋子, 稲田 靖則, 中野 敬介, 長塚仁
  • Organizer: 第３１回日本臨床口腔病理学会 学術大会
• [Presentation] 動物モデルを用いた高転移臓器における転移促進的微小環境の検討 (2019)
  • Author(s): 河合穂高、辻極秀次、メイワトウ、吉田沙織、高畠清文、中野敬介、長塚 仁
  • Organizer: 第108回日本病理学会総会
• [Presentation] 口腔扁平上皮癌にけるCXCR4の腫瘍血管新生への関与 (2019)
  • Author(s): 吉田沙織、河合穂高、Anqi Chang、高畠清文、浜田芽衣、藤井昌江、中野敬介、長塚 仁
  • Organizer: 第108回日本病理学会総会
• [Presentation] コレステリン肉芽腫における骨髄由来免疫抑制細胞（MDSC）の免疫組織化学的検討 (2019)
  • Author(s): 中野敬介、河合穂高、高畠清文、吉田沙織、大森悠加、長塚 仁、川上敏行
  • Organizer: 第108回日本病理学会総会
• [Presentation] 口腔扁平上皮癌が作り出す腫瘍微小環境における骨髄由来細胞の役割 (2019)
  • Author(s): Chang Anqi、高畠清文、吉田沙織、May Wathone Oo、大森悠加、河合穂高、中野敬介、長塚 仁
  • Organizer: 第108回日本病理学会総会
• [Presentation] 腫瘍組織に動員される骨髄由来細胞へ腫瘍間質が及ぼす影響の検討 (2019)
  • Author(s): May Wthone Oo、河合穂高、吉田沙織、髙畠清文、中野敬介、長塚 仁
  • Organizer: 第108回日本病理学会総会
• [Presentation] CXCR4の阻害が口腔扁平上皮癌の腫瘍血管に与える影響 (2019)
  • Author(s): 吉田沙織、河合穂高、May Wthone Oo、Chang Anqi、浜田芽衣、髙畠清文、中野敬介、長塚 仁
  • Organizer: 第108回日本病理学会総会
• [Presentation] 高転移臓器における転移促進的微小環境の性質の検討 (2019)
  • Author(s): 河合穂高、信長ひかり、May Wathone、吉田沙織、大森悠加、髙畠清文、中野敬介、辻極秀次、長塚 仁
  • Organizer: 第61回歯科基礎医学会学術大会・総会
• [Presentation] 新しい腫瘍オルガノイド多元評価システムの開発 (2019)
  • Author(s): 十川千春、江口傑徳、大山和美、奥舎有加、中野敬介、十川紀夫、岡元邦彰
  • Organizer: 第61回歯科基礎医学会学術大会・総会
• [Presentation] 口腔扁平上皮癌診断・治療における分子シャペロンHSP90含有エクソソームの可能性 (2019)
  • Author(s): 小野喜章、江口傑徳、中野敬介、河合穂高、佐々木朗
  • Organizer: 第64回日本口腔外科学会総会・学術大会
• [Presentation] Investigetion of the premetastasis niche's character in high metastatic organs (2019)
  • Author(s): 河合穂高
  • Organizer: 第4回岡山医療教育国際シンポジウム
  • Int'l Joint Research
• [Presentation] エナメル上腫および間質との相互作が骨組織におよぼす影響について (2018)
  • Author(s): 澄 文香，阪上峻基，浜田芽衣，高畠清文，長塚 仁，辻極秀次
  • Organizer: 硬組織再生生物学会総会
• [Presentation] 口腔扁平上癌における腫瘍間質による腫瘍実質の生物学的性格制御について (2018)
  • Author(s): 高畠清文, 河合穂高, 吉田沙織, 松田寛之, 藤井昌江, 中野敬介, 長塚仁
  • Organizer: 硬組織再生生物学会
• [Presentation] 口腔扁平上皮癌細胞由来ＥＶの網羅的プロテオーム解析による腫瘍進展・転移因子の探索． (2018)
  • Author(s): 小野喜章，江口傑徳，中野敬介，河合穂高，佐々木朗．
  • Organizer: 日本口腔外科学会
• [Presentation] 口腔と舌可動域における腫瘍性病変の細胞診． (2018)
  • Author(s): 中野敬介
  • Organizer: 岡山県臨床細胞学会・学術集会
  • Invited
• [Book] 口腔外科学 第４版 (2020)
  • Author(s): 中野敬介、長塚 仁
  • Total Pages: 862
  • Publisher: 医歯薬出版
  • ISBN: 9784263458433
• [Book] 口腔がん早期発見のための口腔細胞診入門 歯科医院で取り組むLBC (2020)
  • Author(s): 中野敬介
  • Total Pages: 120
  • Publisher: 医歯薬出版
  • ISBN: 9784263462188
• [Book] 病理組織の見方と鑑別診断 第7版 (2020)
  • Author(s): 中野敬介、長塚 仁
  • Total Pages: 768
  • Publisher: 医歯薬出版
  • ISBN: 9784263731970
• [Book] Hedgehog Signaling in Organogenesis and Tumor Microenvironment (2020)
  • Author(s): Kiyofumi Takabatake, Tsuyoshi Shimo, Jun Murakami, Chang Anqi, Hotaka Kawai, Saori Yoshida, May Wathone Oo, Omori Haruka, Shintaro Sukegawa, Hidetsugu Tsujigiwa, Keisuke Nakano and Hitoshi Nagatsuka
  • Total Pages: 161
  • Publisher: MDPI
  • ISBN: 9784263731970
• [Book] Histology (2019)
  • Author(s): Kawakami T, Kaneko K, Takaya T, Aoki S, Muraoka R, Tomida M, Okafuji N, Shoumura M, Osuga N, Nakano K, Tsujigiwa H, Nagatuka H.
  • Publisher: IntechOpen
  • ISBN: 9781789849714
• [Book] Histology (2018)
  • Author(s): Kawakami T, Kaneko K, Takaya T, Aoki S, Muraoka R, Tomida M, Okafuji N, Shoumura M, Osuga N, Nakano K, Tsujigiwa H, Nagatuka H.
  • Total Pages: 135
  • Publisher: IntechOpen
  • ISBN: 9781789849707
• [Book] 新口腔病理学 (2018)
  • Author(s): 長塚 仁，中野敬介
  • Total Pages: 359
  • Publisher: 医歯薬出版株式会社
  • ISBN: 9784263458150
• [Book] 口腔病理アトラス 第3版 (2018)
  • Author(s): 長塚 仁
  • Total Pages: 358
  • Publisher: 文光堂書店
  • ISBN: 9784830670046
• [Book] カラーアトラス 病理組織の見方と鑑別診断 第6版 (2018)
  • Author(s): 長塚 仁，中野敬介
  • Total Pages: 562
  • Publisher: 医歯薬出版株式会社
  • ISBN: 9784263731857
• [Remarks] 岡山大学 研究者総覧
  • URL: https://soran.cc.okayama-u.ac.jp/html/4d3759f0c41248c874506e4da22f6611_ja.html?k=%E4%B8%AD%E9%87%8E%E6%95%AC%E4%BB%8B