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New Developments in Molecular Diagnosis and Therapy of Oral Cancer by Targeting MIA2-related Signals

Research Project

Project/Area Number 18K09796
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionNara Medical University

Principal Investigator

Kurihara Miyako  奈良県立医科大学, 医学部附属病院, 研究員 (40453170)

Co-Investigator(Kenkyū-buntansha) 笹平 智則  鹿児島大学, 医歯学域歯学系, 教授 (90405374)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords口腔癌 / MIA family / MIA2
Outline of Final Research Achievements

Melanoma inhibitory activity (MIA family) is a secreted protein involved in the progression of oral cancer. During the course of this study, the applicants newly identified pyruvate kinase (PKM), miR29b-1-5p, non-SMC condensin I complex subunit H (NCAPH), and mucin20 (MUC20) as signals related to the MIA family. The results of this study are as follows. Although these molecules have different functions, they were all found to be factors that promote the progression of oral cancer.

Academic Significance and Societal Importance of the Research Achievements

MIA familyは分泌タンパクであることから血液や尿などの体液からも検出可能であり、治療だけではなく診断標的としての利用も可能である。特に、唾液中にも分泌されることより、低侵襲かつ繰り返し検査が可能な診断マーカーとしての有用性も示唆される。口腔癌は進行癌として見つかることが多いだけでなく、術後の顔貌の変化が余儀なくされるために審美性の低下によるQOLの低下が大きな問題となる。申請者らが見いだした知見は、口腔癌の早期発見・早期治療のあらたな診断、治療標的として臨床応用への展開が期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (15 results)

All 2021 2020 2019 2018

All Journal Article (11 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 11 results,  Open Access: 5 results) Presentation (4 results)

  • [Journal Article] SERPINE2 is an oral cancer-promoting factor that induces angiogenesis and lymphangiogenesis2021

    • Author(s)
      Sasahira T, Kurihara-Shimomura M, Shimomura H, Kirita T
    • Journal Title

      Int J Clin Oncol

      Volume: 26 Issue: 10 Pages: 1831-1839

    • DOI

      10.1007/s10147-021-01970-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of oral squamous cell carcinoma markers MUC2 and SPRR1B downstream of TANGO2020

    • Author(s)
      Sasahira T, Kurihara-Shimomura M, Shimomura H, Bosserhoff AK, Kirita T
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 147 Issue: 6 Pages: 1659-1672

    • DOI

      10.1007/s00432-021-03568-9

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sushi repeat containing Protein X-linked 2 Is a downstream signal of LEM domain containing 1 and acts as a2020

    • Author(s)
      Sasahira T, Kurihara-Shimomura M, Nishiguchi Y, Shimomura H, Kirita T
    • Journal Title

      Int J Mol Sci

      Volume: 21 Issue: 10 Pages: 3655-3655

    • DOI

      10.3390/ijms21103655

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Peroxidan plays a tumor-promoting role in oral squamous cell carcinoma2020

    • Author(s)
      Kurihara-Shimomura M, Sasahira T, Shimomura H, Kirita T
    • Journal Title

      Int J Mol

      Volume: 21 Issue: 15 Pages: 5416-5416

    • DOI

      10.3390/ijms21155416

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Non-SMC condensin I complex subunit H (NCAPH) is associated with lymphangiogenesis and drug resistance2019

    • Author(s)
      Shimomura H, Sasahira T, Nakashima C, Kurihara-Shimomura M, Kirita T
    • Journal Title

      J Clin Med

      Volume: 9 Issue: 1 Pages: 72-72

    • DOI

      10.3390/jcm9010072

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma2019

    • Author(s)
      Kurihara-Shimomura M, Sasahira T, Shimomura H, Bosserhoff AK, Kirita T
    • Journal Title

      Int J Oncol

      Volume: 56 Pages: 1093-1100

    • DOI

      10.3892/ijo.2020.4996

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma2018

    • Author(s)
      10.1136/jclinpath-2017-204770
    • Journal Title

      J Clin Pathol

      Volume: 71 Issue: 5 Pages: 436-41

    • DOI

      10.1136/jclinpath-2017-204770

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma2018

    • Author(s)
      Sasahira T, Nishiguchi Y, Kurihara-Shimomura M, Nakashima C, Kuniyasu H, Kirita T
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 144 Issue: 5 Pages: 875-882

    • DOI

      10.1007/s00432-018-2612-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma2018

    • Author(s)
      Shimomura H, Sasahira T, Nakashima C, Shimomura-Kurihara M, Kirita T
    • Journal Title

      Pathology

      Volume: 50 Issue: 6 Pages: 642-47

    • DOI

      10.1016/j.pathol.2018.06.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells2018

    • Author(s)
      Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H, Kirita T
    • Journal Title

      Int J Mol Sci

      Volume: 19 Issue: 10 Pages: 10-10

    • DOI

      10.3390/ijms19102907

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Oncogenic Activity of miR-29b-1-5p Induces the Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma2018

    • Author(s)
      Kurihara-Shimomura M, Sasahira T, Shimomura H, Nakashima C, Kirita T
    • Journal Title

      J Clin Med

      Volume: 8 Issue: 2 Pages: 273-273

    • DOI

      10.3390/jcm8020273

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] SRPX2は口腔癌における新規腫瘍促進因子である2021

    • Author(s)
      笹平智則、栗原 都、下村弘幸、桐田忠昭
    • Organizer
      第39日本口腔腫瘍学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] NCAPHは口腔癌のリンパ管新生、抗癌剤耐性に関与する2021

    • Author(s)
      下村弘幸、栗原 都、桐田忠昭、笹平智則
    • Organizer
      第39日本口腔腫瘍学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Mast cell chymaseはMIA gene familを介した脈管新生を促進する2021

    • Author(s)
      栗原 都、笹平智則、桐田忠昭
    • Organizer
      第39日本口腔腫瘍学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] SRPX2はLEMD1の下流シグナルであり、口腔癌において腫瘍促進性に作用する新規分子である2020

    • Author(s)
      笹平智則、栗原 都、下村弘幸、桐田忠昭
    • Organizer
      第31回日本臨床口腔病理学会総会
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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