New Developments in Molecular Diagnosis and Therapy of Oral Cancer by Targeting MIA2-related Signals
| Project/Area Number |
18K09796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Nara Medical University |
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Principal Investigator |
Kurihara Miyako 奈良県立医科大学, 医学部附属病院, 研究員 (40453170)
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| Co-Investigator(Kenkyū-buntansha) |
笹平 智則 鹿児島大学, 医歯学域歯学系, 教授 (90405374)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口腔癌 / MIA family / MIA2 |
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| Outline of Final Research Achievements |
Melanoma inhibitory activity (MIA family) is a secreted protein involved in the progression of oral cancer. During the course of this study, the applicants newly identified pyruvate kinase (PKM), miR29b-1-5p, non-SMC condensin I complex subunit H (NCAPH), and mucin20 (MUC20) as signals related to the MIA family. The results of this study are as follows. Although these molecules have different functions, they were all found to be factors that promote the progression of oral cancer.
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| Academic Significance and Societal Importance of the Research Achievements |
MIA familyは分泌タンパクであることから血液や尿などの体液からも検出可能であり、治療だけではなく診断標的としての利用も可能である。特に、唾液中にも分泌されることより、低侵襲かつ繰り返し検査が可能な診断マーカーとしての有用性も示唆される。口腔癌は進行癌として見つかることが多いだけでなく、術後の顔貌の変化が余儀なくされるために審美性の低下によるQOLの低下が大きな問題となる。申請者らが見いだした知見は、口腔癌の早期発見・早期治療のあらたな診断、治療標的として臨床応用への展開が期待される。
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Report
(5 results)
Research Products
(15 results)
