Development of a novel general anesthetic method of applying the enhancement of descending pain suppression system by stimulation of dopamine neurons of the nucleus accumbens
| Project/Area Number |
18K09812
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
兼松 隆 九州大学, 歯学研究院, 教授 (10264053)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ドパミン神経 / ドパミン受容体リガンド / カプサイシン / サブスタンスP / 脊髄後角 / 一次知覚神経終末 / スライス実験 / マイクロダイアリシス法 / 線条体 / オプトジェネティクス / GBR-12909 / メタンフェタミン / ホルマリンテスト / ドパミン受容体作動薬 / 全身麻酔要素 / 不動化 / エンケファリン遊離 |
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| Outline of Final Research Achievements |
The intravenous anesthetic propofol did not inhibit pain induced by capsaicin via peripheral nociceptors in sedative state, but did inhibit during anesthesia. In formalin test, which produces comparatively chronic pain, we confirmed that selective dopamine re-uptake inhibitors suppressed formalin-induced pain, and that selective dopamine receptor antagonists reversed the analgesic effect of the inhibitors. These findings suggest that general anesthetics slightly inhibit descending pain suppression system, or do not affect it, and that stimulation of dopamine neurons are effective on surgical pain.
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| Academic Significance and Societal Importance of the Research Achievements |
研究代表者のこれまでの研究で、中枢神経系における抑制性神経であるγ-アミノ酪酸（GABA）神経を内因性GABAにより刺激すると下行性鎮痛系が抑制されることを確認しているが、本研究では、GABA神経の促進により麻酔作用を生じると考えられている静脈麻酔薬のプロポフォールは、下行性鎮痛系の脊髄後角での作用部位である一次知覚神経終末からのサブスタンスP遊離実験により、下行性鎮痛系を軽度抑制するか、少なくとも増強しないことがわかった。また、選択的ドパミン取り込み阻害薬に鎮痛効果があることを明確にしたことから、本研究により、ドパミン神経作用薬は全身麻酔時の鎮痛薬として臨床応用可能であることが示唆された。
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] The indirect γ-aminobutyric acid (GABA) receptor agonist gabaculine-induced loss of the righting reflex may inhibit the descending analgesic pathway.2020
Author(s)
Ogawa, Y., Irifune, M., Mukai, A., Shimizu, Y., Doi, M., Oue, K., Yoshida, M., Kanematsu, T., Morioka, M., Nakata, Y. and Sakai, N.
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Journal Title
Pharmacology Biochemistry and Behavior
Volume: 198
Pages: 173034-173034
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Component of nicotine-induced intracellular calcium elevation mediated throughα3- andα5-containing nicotinic acetylcholine receptors are regulated by cyclic AMP in SH-SY 5Y cells2020
Author(s)
Takahashi, T., Yoshida, T., Harada, K., Miyagi, T., Hashimoto, K., Hide, I., Tanaka, S., Irifune, M. and Sakai, N.
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Journal Title
PLos One
Volume: 15
Issue: 11
Pages: e0242349-e0242349
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Perioperative anesthesia management for an autism spectrum disorder patient who was thought to be difficult to be hospitalized2019
Author(s)
Oda A, Yoshida K, Kouch T, Mukai T, Kikuchi Y, Takahashi T, Yoshinaka T, Oue K, Mukai A, Shimizu C, Oda Y, Okada Y, Irifune M
Organizer
The Asia Association for Disability and Oral Health
Related Report
Int'l Joint Research
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