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Novel orthodontic treatment conserving sound enamel - Application of quantum mechanics, coordination chemistry and plasma physics -

Research Project

Project/Area Number 18K09826
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57070:Developmental dentistry-related
Research InstitutionHokkaido University

Principal Investigator

Yamagata Shuichi  北海道大学, 歯学研究院, 助教 (70292034)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsエナメル質 / ランタノイド / ナノ粒子 / 錯体 / 蛍光 / 矯正装置 / 接着 / ボンディング材 / 希土類元素 / 大気圧低温プラズマ
Outline of Final Research Achievements

A multi bracket appliance is one of the most popular orthodontic appliances, however, damage to enamel such as acid treatment (at the time of gluing) and cutting (at the time of removal) has been considered inevitable. To avoid or reduce such damage, we have been devising modification methods for enamel surface and developing adhesives with visibility only when necessary.
Owing to the support by JSPS KAKENHI Grant Number 18K09826, we have succeeded in fabricating urethane-based fluorescent bonding materials with either europium containing nanoparticles or Eu complexes at a laboratory level. Specifically, Y2O3:Eu3+ and Tris(1,3-diphenyl-1,3-propanedionato)(1,10-phenanthroline)Eu3+ were confirmed to be quite effective to make dimethacrylate adhesives fluorescent.

Academic Significance and Societal Importance of the Research Achievements

歯科領域の大気圧低温プラズマ関連研究には殺菌や漂白、象牙質改質がある。しかし、接着強さためにエナメル質表面改質を扱った報告は見当たらない。有機蛍光色素を用いることで上市された蛍光ボンディング材もあるが、劣化しやすいため用途は限定的である。本研究は希土類元素に着目し、ボンディング材への蛍光特性の付与を着想した点で学術的意義が高い。また、新しいエナメル質表面改質法や蛍光ボンディング材の実現は、歯にダメージを与えない治療方法に直結するという点で社会的意義が高い。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (27 results)

All 2022 2020 2019 2018 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 2 results) Presentation (15 results) (of which Int'l Joint Research: 7 results) Remarks (2 results)

  • [Journal Article] Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure2022

    • Author(s)
      Akasaka Tsukasa、Tamai Miho、Yoshimura Yoshitaka、Ushijima Natsumi、Numamoto Shinichiro、Yokoyama Atsuro、Miyaji Hirofumi、Takata Ryo、Yamagata Shuichi、Sato Yoshiaki、Nakanishi Ko、Yoshida Yasuhiro
    • Journal Title

      Nano Research

      Volume: - Issue: 5 Pages: 4201-4211

    • DOI

      10.1007/s12274-021-4026-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fluorescence and mechanical properties of Y2O3:Eu3+ nanophosphor-containing adhesive resins2020

    • Author(s)
      Yamagata S, Yamamoto T, Sato Y, Ushijima N, Akasaka T, Yoshida Y
    • Journal Title

      Nano Biomedicine

      Volume: 12 Pages: 19-26

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Self-assembled monolayer formation on a dental orthodontic stainless steel wire surface to suppress metal ion elution2020

    • Author(s)
      H. Tamaki, S. Abe, S. Yamagata, Y. Yoshida, and Y. Sato
    • Journal Title

      Coatings

      Volume: 20 Issue: 4 Pages: 36701-09

    • DOI

      10.3390/coatings10040367

    • NAID

      120006988210

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphology and Fluorescence of Y<sub>2</sub>O<sub>3</sub>:Eu<sup>3+</sup> Nanophosphors and Dispersibility in Adhesives Resins2019

    • Author(s)
      Yamagata S, Yamamoto T, Sato Y, Ushijima N, Akasaka T, Yoshida Y
    • Journal Title

      Nano Biomedicine

      Volume: 11 Issue: 2 Pages: 57-64

    • DOI

      10.11344/nano.11.57

    • NAID

      130007801521

    • ISSN
      1883-5198, 2185-4734
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electric Charge Dependence of Controlled Dye-Release Behavior in Glass Ionomer Cement Containing Nano-Porous Silica Particles2018

    • Author(s)
      Bando Y, Nakanishi K, Abe S, Yamagata S, Yoshida Y, Iida J
    • Journal Title

      Journal of Nanoscience and Nanotechnology

      Volume: 18 Issue: 1 Pages: 75-79

    • DOI

      10.1166/jnn.2018.14618

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of a nano-scale fine hole pattern on the differentiation of RAW264.7 cells into osteoclasts2018

    • Author(s)
      Takata R, Akasaka T, Tamai M, Yoshimura Y, Taira T, Miyaji H, Tagawa Y, Yamagata S, Iida J, Yoshida Y
    • Journal Title

      Digest Journal of Nanomaterials and Biostructures

      Volume: 13 Pages: 451-458

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemical modification to suppress metal ions elution of dental orthodontic wire surface2018

    • Author(s)
      H. Tamaki, S. Tsuchiya, Y. Sakurada, S. Yamagata, A. Hyono, K. Kaneko, K. Kawai, S. Abe, Y. Yoshida, and J. Iida
    • Journal Title

      Molecular Crystals and Liquid Crystals

      Volume: 660 Issue: 1 Pages: 163-172

    • DOI

      10.1080/15421406.2018.1457279

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optical and Chromatic Evaluation of Fluorescent Orthodontic Bonding Materials Doped with a Europium β-diketonate Complex2018

    • Author(s)
      A. Matsumoto, S. Yamagata, S. Abe, T. Akasaka, Y. Yoshida, and J. Iida
    • Journal Title

      Nano Biomedicine

      Volume: 10 Issue: 1 Pages: 3-8

    • DOI

      10.11344/nano.10.3

    • NAID

      130007438742

    • ISSN
      1883-5198, 2185-4734
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Light-curing Type Fluorescent Orthodontic Bonding Materials using Europium-β-diketonate Complex2018

    • Author(s)
      S. Yamagata, T. Yamamoto, Y. Sato, S. Abe, T. Akasaka, and Y. Yoshida
    • Journal Title

      Nano Biomedicine

      Volume: 10 Issue: 2 Pages: 53-60

    • DOI

      10.11344/nano.10.53

    • NAID

      130007607966

    • ISSN
      1883-5198, 2185-4734
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fusion of RAW 264.7 macrophage cells on micro-scale fine pillar pattern2018

    • Author(s)
      Honma J, Akasaka T, Tamai M, Yoshimura Y, Taira T, Miyaji H, Yamagata S, Sato Y, Yoshida Y
    • Journal Title

      Digest Journal of Nanomaterials and Biostructures

      Volume: 13 Pages: 1123-1131

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Properties of novel urethane-based fluorescent bonding materials containing europium-β-diketonate complex2020

    • Author(s)
      Yamagata S, Yamamoto T, Yoshida Y, Sato Y
    • Organizer
      The 9th International Orthodontic Congress
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of the ability of nanoporous silica to release antimicrobial agents depending on the pore size2020

    • Author(s)
      Endo R, Nakanishi K, Bando Y, Abe S, Yamagata S, Yoshida Y, Sato Y
    • Organizer
      The 9th International Orthodontic Congress
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 矯正歯科治療へのグリコール変性ポリエチレンテレフタレートの新しい応用2020

    • Author(s)
      高田 亮,山方秀一,斉藤文男,山本隆昭,佐藤嘉晃
    • Organizer
      第61回北海道矯正歯科学会総会・学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Multifunctional surface modification on dental orthodontic wire surface: Suppression of metal ions elution and antibacterial property2019

    • Author(s)
      Tamaki H, Abe S, Yamagata S, Yoshida Y, Iida J, Sato Y
    • Organizer
      The 17th International Nanotech Symposium & Exhibition (NANO KOREA 2019 Symposium)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ナノ多孔質シリカの孔サイズがもたらすイオン放出能への影響2019

    • Author(s)
      遠藤諒俊,中西 康,坂東洋祐,松本愛子,阿部薫明,山方秀一,吉田靖弘,佐藤嘉晃
    • Organizer
      第78回日本矯正歯科学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Effect of particle and pore size of nano porous silica on ion release ability2019

    • Author(s)
      Endo R, Nakanishi K, Bando Y, Abe S, Yamagata S, Yoshida Y, Sato Y
    • Organizer
      The 19th Asian BioCeramics Symposium (2019ABC)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Drug sustain-relaease property of glass ionomer cement containing nano-porous silica2018

    • Author(s)
      Nakanishi K, Bando Y, Abe S, Yamagata S, Yoshida Y, Iida J
    • Organizer
      The 96th General Session & Exhibition of the IADR, which was held in conjunction with the IADR Pan European Regional Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of novel multi-functional glass ionomer cement using nano-porous silica2018

    • Author(s)
      Bando Y, Nakanishi K, Abe S, Yamagata S, Yoshida Y, Iida J
    • Organizer
      The 96th General Session & Exhibition of the IADR, which was held in conjunction with the IADR Pan European Regional Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] マイクロナノパターン構造を付与したCOP filmによる細胞接着への影響について2018

    • Author(s)
      本間 淳,赤坂 司,山方秀一,佐藤嘉晃,吉田靖弘
    • Organizer
      2018年日本バイオマテリアル学会北海道ブロック第3回研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] ユウロピウム錯体を用いた矯正歯科用蛍光ボンディング材の試作2018

    • Author(s)
      山方秀一,佐藤嘉晃,阿部薫明,赤坂 司,吉田靖弘
    • Organizer
      第72回日本歯科理工学会秋季学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] マイクロ・ナノ構造が細胞接着にもたらす影響2018

    • Author(s)
      高田 亮,赤坂 司,山方秀一,佐藤嘉晃,飯田順一郎,吉田靖弘
    • Organizer
      第77回日本矯正歯科学会学術大会・第7回日韓ジョイントミーティング
    • Related Report
      2018 Research-status Report
  • [Presentation] 矯正歯科用ステンレスワイヤーへのイオン溶出抑制を目的とした表面化学修飾2018

    • Author(s)
      玉木宏典,阿部薫明,山方秀一,佐藤嘉晃,飯田順一郎,吉田靖弘
    • Organizer
      第77回日本矯正歯科学会学術大会・第7回日韓ジョイントミーティング
    • Related Report
      2018 Research-status Report
  • [Presentation] Chemical modification on dental orthodontic wire surface for suppression of metal ions elution and antibacterial property2018

    • Author(s)
      Tamaki H, Tsuchiya S, Abe S, Yamagata S, Yoshida Y, Iida J
    • Organizer
      28th International Conference and Expo on Nanosciences and Nanotechnology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] マイクロ・ナノ構造が歯周組織関連細胞の挙動にもたらす影響2018

    • Author(s)
      高田 亮,赤坂 司,山方秀一,佐藤嘉晃,吉田靖弘
    • Organizer
      平成30年度北海道歯学会秋季学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] マイクロ・サブミクロパターン構造を付与したCOP film上における細胞挙動2018

    • Author(s)
      本間 淳,赤坂 司,山方秀一,佐藤嘉晃,吉田靖弘
    • Organizer
      平成30年度北海道歯学会秋季学術大会
    • Related Report
      2018 Research-status Report
  • [Remarks] 北海道大学大学院歯学研究院口腔機能学分野歯科矯正学教室研究内容

    • URL

      https://www.den.hokudai.ac.jp/orthodontics/research/ken04/

    • Related Report
      2021 Annual Research Report 2020 Research-status Report 2019 Research-status Report 2018 Research-status Report
  • [Remarks] 北海道大学大学院歯学研究院口腔機能学分野歯科矯正学教室研究業績

    • URL

      https://www.den.hokudai.ac.jp/orthodontics/publication/

    • Related Report
      2021 Annual Research Report 2020 Research-status Report 2019 Research-status Report 2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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