| Project/Area Number |
18K09843
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57070:Developmental dentistry-related
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| Research Institution | Meikai University |
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Principal Investigator |
SUDA Naoto 明海大学, 歯学部, 教授 (90302885)
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| Co-Investigator(Kenkyū-buntansha) |
村本 和世 明海大学, 歯学部, 教授 (10301798)
安達 一典 明海大学, 歯学部, 教授 (20349963)
坂上 宏 明海大学, 歯学部, 教授 (50138484)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯の移動 / 疼痛 / TRPV1 / 矯正治療 / TRPV / 末梢性疼痛 / サテライトグリア細胞 / グリア線維性酸性タンパク質 / GFAP / 鎮痛薬 / 疼痛抑制 / レーザー / 動物実験 / CO2レーザー / 半導体レーザー / 痛覚 / 矯正歯科治療 / 中枢 / 末梢 |
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| Outline of Final Research Achievements |
The effects of topical administration of TRPV1 and / or TRPA1 antagonists to cervical gingiva on the orthodontic force induced pain and the trigeminal excitability were examined. Each TRP antagonist expressed an analgesic effect on orthodontic force induced pain; however, trigeminal excitation (e.g., GFAP expression in ganglia) was not inhibited. Moreover, the co-administration of both TRP antagonists significantly increased the analgesic effect without inducing temperature alteration. Taken together, the cooperative effect of TRP antagonists may play a critical role in controlling orthodontic force-induced pain.
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| Academic Significance and Societal Importance of the Research Achievements |
矯正力負荷に伴う疼痛と三叉神経節活性に対するTRPV1とTRPA1拮抗薬の歯肉塗布の効果を検討した．その結果，いずれの拮抗薬も矯正装置装着後1日後に塗布することで，単独で用量依存的に鎮痛効果を発現した．しかし，その効果は先行研究のTRPV1拮抗薬全身投与やレーザー照射と比較して有意に低く，三叉神経節のGFAP発現も抑制されなかった．しかしながら，両者を併用することで鎮痛効果は有意に増強され，TRPV1拮抗薬の全身投与やレーザー照射と同等の効果を得ることが出来た．また，その際に，歯肉溝温度と直腸温に変化はみられず，矯正臨床における疼痛制御への有効性が示された．
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