• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Peripheral and central intervention to pain during orthodontic tooth movement

Research Project

Project/Area Number 18K09843
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57070:Developmental dentistry-related
Research InstitutionMeikai University

Principal Investigator

SUDA Naoto  明海大学, 歯学部, 教授 (90302885)

Co-Investigator(Kenkyū-buntansha) 村本 和世  明海大学, 歯学部, 教授 (10301798)
安達 一典  明海大学, 歯学部, 教授 (20349963)
坂上 宏  明海大学, 歯学部, 教授 (50138484)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords歯の移動 / 疼痛 / TRPV1 / 矯正治療 / TRPV / 末梢性疼痛 / サテライトグリア細胞 / グリア線維性酸性タンパク質 / GFAP / 鎮痛薬 / 疼痛抑制 / レーザー / 動物実験 / CO2レーザー / 半導体レーザー / 痛覚 / 矯正歯科治療 / 中枢 / 末梢
Outline of Final Research Achievements

The effects of topical administration of TRPV1 and / or TRPA1 antagonists to cervical gingiva on the orthodontic force induced pain and the trigeminal excitability were examined. Each TRP antagonist expressed an analgesic effect on orthodontic force induced pain; however, trigeminal excitation (e.g., GFAP expression in ganglia) was not inhibited. Moreover, the co-administration of both TRP antagonists significantly increased the analgesic effect without inducing temperature alteration. Taken together, the cooperative effect of TRP antagonists may play a critical role in controlling orthodontic force-induced pain.

Academic Significance and Societal Importance of the Research Achievements

矯正力負荷に伴う疼痛と三叉神経節活性に対するTRPV1とTRPA1拮抗薬の歯肉塗布の効果を検討した.その結果,いずれの拮抗薬も矯正装置装着後1日後に塗布することで,単独で用量依存的に鎮痛効果を発現した.しかし,その効果は先行研究のTRPV1拮抗薬全身投与やレーザー照射と比較して有意に低く,三叉神経節のGFAP発現も抑制されなかった.しかしながら,両者を併用することで鎮痛効果は有意に増強され,TRPV1拮抗薬の全身投与やレーザー照射と同等の効果を得ることが出来た.また,その際に,歯肉溝温度と直腸温に変化はみられず,矯正臨床における疼痛制御への有効性が示された.

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (24 results)

All 2021 2020 2019 2018

All Journal Article (12 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 4 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results) Book (2 results)

  • [Journal Article] Regeneration in experimental alveolar bone defect using human umbilical cord mesenchymal stem cells2021

    • Author(s)
      Toyota A, Shinagawa R, Mano M, Tokioka K, Suda N
    • Journal Title

      Cell Transplantation

      Volume: 30 Pages: 1-15

    • DOI

      10.1177/0963689720975391

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Orthodontic treatment of a skeletal Class III case with severe root resorption of the maxillary anterior teeth2021

    • Author(s)
      Sasaki A, Suda N
    • Journal Title

      American Journal of Orthodontics & Dentofacial Orthopedics

      Volume: 印刷中

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smad4-dependent transforming growth factor-β family signaling regulates the differentiation of dental epithelial cells in adult mouse incisors.2020

    • Author(s)
      Machiya A, Tsukamoto S, Ohte S, Kuratani M, Suda N, Katagiri T.
    • Journal Title

      Bone

      Volume: - Pages: 115456-115456

    • DOI

      10.1016/j.bone.2020.115456

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Le Fort I型骨切り術により上顎骨の前下方移動とyawingの改善を図った左側唇顎口蓋裂の1例2020

    • Author(s)
      藤本舞、佐々木会、藤本航大、真野樹子、坂下英明、時岡一幸、須田直人
    • Journal Title

      日本口蓋裂学会雑誌

      Volume: 45 Pages: 225-236

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 頭蓋冠形態と下顎窩の位置の三次元解析 -第2報 非対称を伴う骨格性下顎前突症例を用いた検討-2020

    • Author(s)
      山口浩司、佐々木会、川尻朱美、藤本航大、上里忠成、豊田亜希子、須田直人
    • Journal Title

      日顎変形誌

      Volume: 30 Pages: 267-280

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 術前顎矯正治療における光学印象の試み(第3報)-撮像時の専用パウダー噴霧の影響と両側性唇顎裂児への口蓋床の装着-2020

    • Author(s)
      長谷川拡也、真野樹子、野尻尚子、土屋隆子、藤本舞、藤本航大、須田直人
    • Journal Title

      Orthodontic Waves

      Volume: 79 Pages: 11-19

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 上顎両側中切歯の抜去と切歯乳頭を切除した一例2019

    • Author(s)
      大貫那未、佐々木会、須田直人
    • Journal Title

      東京矯正歯科学会雑誌

      Volume: 29 Pages: 118-120

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] ニッケルアレルギーを有し上下顎歯列の狭窄に伴う上顎前歯重度叢生症例の一例2019

    • Author(s)
      長谷川尚哉、真野樹子、須田直人
    • Journal Title

      明海歯科医学

      Volume: 48 Pages: 57-65

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] モンゴル人の顔面非対称女性症例の特徴2019

    • Author(s)
      Dashdondog Otogontuya, Ganburged Ganjargal, 須田直人
    • Journal Title

      明海歯科医学

      Volume: 48 Pages: 1-7

    • NAID

      40021832956

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Short lingual osteotomyを施行した骨格性下顎前突症における術後安定性と内側翼突筋の三次元評価2019

    • Author(s)
      東金由莉、佐々木会、大塚雄一郎、上里忠成、川尻朱美、山口浩司、園川拓哉、小沢智宣、虻川東嗣、高橋伸年、鬼頭真司、嶋田淳、須田直人
    • Journal Title

      日本顎変形症学会雑誌

      Volume: 29 Pages: 269-279

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recent Progress of Basic Studies of Natural Products and Their Dental Application.2018

    • Author(s)
      Sakagami H, Watanabe T, Hoshino T, Suda N, Mori K, Yasui T, Yamauchi N, Kashiwagi H, Gomi T, Oizumi T, Nagai J, Uesawa Y, Takao K, Sugita Y.
    • Journal Title

      Medicines (Basel)

      Volume: 6 Issue: 1 Pages: 4-4

    • DOI

      10.3390/medicines6010004

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders2018

    • Author(s)
      Machiya Aiko、Tsukamoto Sho、Ohte Satoshi、Kuratani Mai、Fujimoto Mai、Kumagai Keigo、Osawa Kenji、Suda Naoto、Bullock Alex N.、Katagiri Takenobu
    • Journal Title

      Bone

      Volume: 111 Pages: 101-108

    • DOI

      10.1016/j.bone.2018.03.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Early alveolar cleft closure using human umbilical cord mesenchymal stem cells in experimental animal model2020

    • Author(s)
      Suda N
    • Organizer
      9th International Orthodontic Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Alteration of satellite glial GFAP expression by laser irradiation in experimental tooth movement model2020

    • Author(s)
      Yugawa M, Tsuchiya T, Hasegawa N, Sasaki A, Adachi K, Suda N
    • Organizer
      9th International Orthodontic Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 三叉神経節サテライトグリアのGFAP活性に対する矯正治療の影響2019

    • Author(s)
      湯川未郷、土屋隆子、長谷川尚哉、佐々木会、安達一典、須田直人
    • Organizer
      第78回日本矯正歯科学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Irregular alignment in orthodontic treatment2019

    • Author(s)
      Suda N
    • Organizer
      The 7th Annual meeting of Mongolian association of Orthodontists
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Vertical correction in short face cases with cleft lip and palate2019

    • Author(s)
      Suda N
    • Organizer
      The 58th Congress of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 4つの咀嚼筋の情報を付加した顎矯正手術三次元シミュレーション2019

    • Author(s)
      大塚雄一郎、大島隆史、箕田碧、須田直人
    • Organizer
      第78回日本矯正歯科学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 下顎窩の三次元的位置と下顎骨体長の関連性2019

    • Author(s)
      藤本航大、佐々木会、川尻朱美、山口浩司、上里忠成、東金由莉、大塚雄一郎、須田直人
    • Organizer
      第78回日本矯正歯科学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Orthodontic treatment for traumatic cases2018

    • Author(s)
      Suda N
    • Organizer
      6th Meeting of Mongolian Association of Orthodontists
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] .マルファン症候群の早期発見と矯正歯科. 知っておきたい先天異常の特徴.2018

    • Author(s)
      須田直人
    • Organizer
      第77回日本矯正歯科学会学術大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 実験的歯の移動に伴う疼痛に対するCO2レーザーと半導体レーザーの照射効果2018

    • Author(s)
      土屋隆子、湯川未郷、長谷川尚哉、安達一典、須田直人
    • Organizer
      第77回日本矯正歯科学会学術大会
    • Related Report
      2018 Research-status Report
  • [Book] Down症候群の医療管理2019

    • Author(s)
      須田直人
    • Total Pages
      912
    • Publisher
      東京医学社
    • Related Report
      2019 Research-status Report
  • [Book] 歯科矯正学 第6版2019

    • Author(s)
      須田直人 (編者:飯田順一郎ら他5名)
    • Publisher
      医歯薬出版
    • Related Report
      2019 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi