Peripheral and central intervention to pain during orthodontic tooth movement
| Project/Area Number |
18K09843
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57070:Developmental dentistry-related
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| Research Institution | Meikai University |
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Principal Investigator |
SUDA Naoto 明海大学, 歯学部, 教授 (90302885)
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| Co-Investigator(Kenkyū-buntansha) |
村本 和世 明海大学, 歯学部, 教授 (10301798)
安達 一典 明海大学, 歯学部, 教授 (20349963)
坂上 宏 明海大学, 歯学部, 教授 (50138484)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯の移動 / 疼痛 / TRPV1 / 矯正治療 / TRPV / 末梢性疼痛 / サテライトグリア細胞 / グリア線維性酸性タンパク質 / GFAP / 鎮痛薬 / 疼痛抑制 / レーザー / 動物実験 / CO2レーザー / 半導体レーザー / 痛覚 / 矯正歯科治療 / 中枢 / 末梢 |
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| Outline of Final Research Achievements |
The effects of topical administration of TRPV1 and / or TRPA1 antagonists to cervical gingiva on the orthodontic force induced pain and the trigeminal excitability were examined. Each TRP antagonist expressed an analgesic effect on orthodontic force induced pain; however, trigeminal excitation (e.g., GFAP expression in ganglia) was not inhibited. Moreover, the co-administration of both TRP antagonists significantly increased the analgesic effect without inducing temperature alteration. Taken together, the cooperative effect of TRP antagonists may play a critical role in controlling orthodontic force-induced pain.
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| Academic Significance and Societal Importance of the Research Achievements |
矯正力負荷に伴う疼痛と三叉神経節活性に対するTRPV1とTRPA1拮抗薬の歯肉塗布の効果を検討した．その結果，いずれの拮抗薬も矯正装置装着後1日後に塗布することで，単独で用量依存的に鎮痛効果を発現した．しかし，その効果は先行研究のTRPV1拮抗薬全身投与やレーザー照射と比較して有意に低く，三叉神経節のGFAP発現も抑制されなかった．しかしながら，両者を併用することで鎮痛効果は有意に増強され，TRPV1拮抗薬の全身投与やレーザー照射と同等の効果を得ることが出来た．また，その際に，歯肉溝温度と直腸温に変化はみられず，矯正臨床における疼痛制御への有効性が示された．
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Recent Progress of Basic Studies of Natural Products and Their Dental Application.2018
Author(s)
Sakagami H, Watanabe T, Hoshino T, Suda N, Mori K, Yasui T, Yamauchi N, Kashiwagi H, Gomi T, Oizumi T, Nagai J, Uesawa Y, Takao K, Sugita Y.
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Journal Title
Medicines (Basel)
Volume: 6
Issue: 1
Pages: 4-4
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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