Effects of anti-bone resorptive drugs on growth and tooth development in young mice.
Project/Area Number |
18K09866
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 57070:Developmental dentistry-related
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Research Institution | Showa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
高見 正道 昭和大学, 歯学部, 教授 (80307058)
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 歯牙萌出 / 抗RANKL抗体 / ビスホスホネート / 破骨細胞 / 骨芽細胞 / 骨発達 / ビスフォスフォネート / 小児骨代謝 |
Outline of Final Research Achievements |
Anti-bone-resorptive drugs are used to treat children’s bone disease, however, the precise effects on tooth eruption are unknown. In the present study, we administrated an anti-RANKL antibody or zoledronate (a bisphosphonate) on 1-week-old mice to made osteoclast-suppressed model mice and analyzed the effect of anti-resorptive drugs on growth and tooth development in young mice. The anti-resorptive drugs decreased expression of immune cells in bone marrow in infants. Mice, which were continuously treated with zoledronate, showed delay of tooth eruption and decreased number of osteoblasts, and inhibited growth of jaw bone, cranial bone and limb after growth. These results suggest that anti-bone-resorptive drugs are affects tooth development in young patients.
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Academic Significance and Societal Importance of the Research Achievements |
抗RANKL抗体(一般名デノスマブ)、およびゾレドロネートなどのビスホスホネート製剤は、成人の骨疾患の治療に高い効果を発揮する優れた骨吸収抑制薬である。骨吸収抑制薬は治療の必要性から小児の骨形成不全症やステロイド性骨粗鬆症などの治療に用いられているが、小児の成長に対する影響は未解明な部分が多い。 本研究では小児期の骨吸収抑制薬投与が成体にも影響を及ぼすことを明らかにした。これは骨吸収抑制薬を小児に投与する際に、免疫機能や成長を注意深く確認して投薬計画を調整する必要があることを示すものであり、治療後のQOL向上に大きく貢献する成果である。
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Effects of N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice2020
Author(s)
Kiyohara S, Sakai N, Handa K, Yamakawa T, Ishikawa K, Chatani M, Karakawa A, Azetsu Y, Munakata M, Ozeki M, Negishi-Koga T, Takami M
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Journal Title
J Oral Biosci
Volume: -
Issue: 2
Pages: 131-138
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effects of lipid metabolism on mouse incisor dentinogenesis.2020
Author(s)
Kurotaki, Y., Sakai, N., Miyazaki, T., Hosonuma, M., Sato, Y., Karakawa, A., Chatani, M., Myers, M., Suzawa, T., Negishi-Koga, T., Kamijo, R., Miyazaki, A., Maruoka, Y., Takami, M.
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 5102-5102
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Myelination during fracture healing in vivo in myelin protein zero (p0) transgenic medaka line2020
Author(s)
Dodo Y, Chatani M, Azetsu Y, Hosonuma M, Karakawa A, Sakai N, Negishi-Koga T, Tsuji M, Inagaki K, Kiuchi Y, Takami M
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Journal Title
Bone
Volume: 133
Pages: 115225-115225
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice2019
Author(s)
Isawa M, Karakawa, Sakai N, Nishina S, Kuritani M, Chatani M, Negishi-Koga T, Sato M, Inoue M, Shimada Y, Takami M
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Journal Title
Sci Rep
Volume: 9(1)
Issue: 1
Pages: 19895-19895
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bone loss caused by dopaminergic degeneration and levodopa treatment in Parkinson’s disease model mice2019
Author(s)
Handa K, Kiyohara S, Yamakawa T, Ishikawa K, Hosonuma M, Sakai N, Karakawa A, Chatani M, Tsuji M, Inagaki K, Kiuchi Y, Takami M, Negishi-Koga T
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Journal Title
Sci Rep
Volume: 9(1)
Pages: 13768-13768
Related Report
Peer Reviewed / Open Access
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