Effects of Blimp-1 for chemotherapy induced oral mucositis
| Project/Area Number |
18K09883
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57080:Social dentistry-related
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北浦 英樹 東北大学, 歯学研究科, 准教授 (60295087)
藤村 裕治 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (70448504)
小原 悠 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (70623825)
森田 幸子 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (00631574)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔粘膜炎 / Blimp-1 |
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| Outline of Final Research Achievements |
It has been reported that suppression of Blimp-1 caused inhibition of TNF-alpha induced osteoclastogenesis. Appearance of oral mucositis is related with TNF-alpha. Therefore, we predicted that Blimp-1, induced by immune response, might be related with oral mucositis. For that, model of oral mucositis in mice was used with intraperitoneally injection of 5-FU. After expression of oral mucositis, localizaion of Blimp-1 was histologically evaluated using immunostaining. The expression of Blimp-1 was not recognized in the region of oral mucositis. The results suggest that Blimp-1 unlikely express in oral mucositis induced by chemotherapy.
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| Academic Significance and Societal Importance of the Research Achievements |
がんで化学療法を行う患者の多くは口腔粘膜炎を発症し、QOLが低下する人が少なくない。がんが発症しても治療を続けながら、それまでと同程度の社会生活を送れることを願うが、様々な副作用があるためそうはいかない。その一つとしての口腔粘膜炎に関しては、発症を抑制して不快なく食事ができることが重要である。現在のところ口腔粘膜炎の対症療法はあるが、発症を抑制するエビデンスレベルの高い方法はない。今回着目したBlimp-1は口腔粘膜炎発症に関わっていると期待したが、予測した結果が得られなかった。今後もがん患者は増加することが予測されるため、口腔粘膜炎発症抑制をめざして新たなアプローチをする必要があると考える。
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] Preventive effects of betamethasone valerate ointment for radiation-induced severe oral mucositis in patients with oral or oropharyngeal cancer: protocol for a multicentre, phase II, randomised controlled trial (Bet-ROM study)2022
Author(s)
Sakiko Soutome, Mitsunobu Otsuru, Maho Murata, Yumiko Kawashita, Masako Yoshimatsu, Madoka Funahara, Yoshiko Yamamura, Takumi Hasegawa, Shin-Ichi Yamada, Yuka Kojima, Hirokazu Nakahara, Yasuyuki Shibuya, Masahiro Umeda, Toshiyuki Saito
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Journal Title
BMJ Open
Volume: 12
Issue: 1
Pages: e056781-e056781
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effects of the changes in the condylar long axis angle and condylar position on temporomandibular symptoms after intraoral vertical ramus osteotomy: a preliminary study2019
Author(s)
Rokutanda S, Yamada SI, Yanamoto S, Sakamoto H, Morita Y, Rokutanda H, Kohara H, Yoshimatsu M, Yoshimi T, Nakamura T, Ino-Kondo A, Moriuchi E, Umeda M.
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Journal Title
Oral Surg Oral Med Oral Pathol Oral Radiol
Volume: 128
Issue: 6
Pages: 597-605
DOI
Related Report
Peer Reviewed
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