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Elucidating the Mechanism of Drug-Induced Taste Disorder Directly Linked to Improved Quality of Life in Hematopoietic Stem Cell Transplant Recipients

Research Project

Project/Area Number 18K09902
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionHokkaido University

Principal Investigator

Abe Takae  北海道大学, 大学病院, 助教 (00455677)

Co-Investigator(Kenkyū-buntansha) 奥舎 有加  岡山大学, 医歯薬学総合研究科, 助教 (50762027)
後藤 秀樹  北海道大学, 大学病院, 助教 (70759290)
山崎 裕  北海道大学, 歯学研究院, 教授 (90250464)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords同種造血幹細胞移植 / 味覚異常 / 前向き縦断調査 / 造血幹細胞移植 / 味覚障害 / LTFU
Outline of Final Research Achievements

A total of 5 times during the period from before HSCT to 12 months after transplantation, taste function tests using the whole-oral method and self-assessment of taste abnormalities by NRS were performed. The pre-transplant NRS already showed 10-20% taste abnormalities in all four taste qualities. In both the post-transplant whole-oral method and NRS, saltiness was the most highly impaired and recovery was most prolonged at 12 months post-transplant. In terms of the nature of the dysgeusia, there was a high rate of decreased taste in all tastes in the first month after transplantation, but from the third month onward, there was a higher rate of hypergeusia.
Salty taste was the most impaired and recovery was prolonged. In all tastes, the percentage of patients with decreased taste sensation in the early period after transplantation increased, followed by a higher percentage of patients with hypergeusia. There was no consistency between subjective symptoms of dysgeusia and taste tests.

Academic Significance and Societal Importance of the Research Achievements

従来から、がん化学療法の味覚異常で一番問題になるのは塩味であることが国内外の研究で報告されていたが、今回の同種造血幹細胞移植においても同様の結果になった。自己評価による味覚異常の過敏・減退の変化に関して本研究では、4味質すべ全てにおいて移植後早期には味覚減退、3か月目からは味覚過敏の割合が高くなった。また、自己評価の減退・過敏と全口腔法の関係を検討したが、自覚的な味覚減退・過敏と全口腔法による他覚的な閾値との間に明確な整合性は認められなかった。味覚過敏を訴える場合に、味覚検査で閾値が低下しているとは限らない。本来とは違う味を意識している場合にも過敏と表現される可能性が考えられた。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2022 2021 2020 2019

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 5 results) Presentation (3 results)

  • [Journal Article] 同種造血幹細胞移植における味覚異常の前向き縦断調査2022

    • Author(s)
      松下貴惠、新井絵理、渡邊 裕、山崎 裕
    • Journal Title

      JSPEN

      Volume: 4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 電撃様疼痛の原因探索に難渋した二次性三叉神経痛の1例2021

    • Author(s)
      稲本香織、中川紗百合、松下貴恵、中澤誠多朗、坂田健一郎、羽藤裕之、渡邊 裕、山崎 裕
    • Journal Title

      北海道私学会雑誌

      Volume: 14 Pages: 147-152

    • NAID

      120006995784

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Study of Taste Disorders in Elderly Patients2020

    • Author(s)
      松下貴惠、岩島佑希、馬場陽久、稲本香織、三浦和仁、岡田和隆、渡邊 裕、山崎 裕
    • Journal Title

      Ronen Shika Igaku

      Volume: 35 Issue: 3 Pages: 209-217

    • DOI

      10.11259/jsg.35.209

    • NAID

      130007975940

    • ISSN
      0914-3866, 1884-7323
    • Year and Date
      2020-12-31
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 漢方治療により味覚異常の他にさまざまな効能が得られた1例2020

    • Author(s)
      武田雅彩、三浦和仁、新井絵理、松下貴惠、山崎 裕
    • Journal Title

      北海道歯学雑誌

      Volume: 40 Pages: 49-53

    • NAID

      120006839804

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 舌痛症に対してそれぞれ異なる漢方治療が奏功した3症例2019

    • Author(s)
      岩島佑希、松下貴惠、中澤誠多朗、尾崎公哉、新井絵里、三浦和仁、山崎 裕
    • Journal Title

      痛みと漢方

      Volume: 29 Pages: 38-44

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] ビスホスホネート長期服用患者に対し薬物性歯肉増殖症の手術的対応を行った1例2019

    • Author(s)
      三浦和仁、松下貴惠、新井絵里、松下和裕、鄭 漢忠、山崎 裕
    • Journal Title

      北海道歯誌

      Volume: 39 Pages: 131-136

    • NAID

      120006606611

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 重度の咽喉頭異常感症に半夏厚朴湯が著効した1例2019

    • Author(s)
      中澤誠多朗、新井絵里、前 壮功仁、岡田和隆、松下貴惠、濱田浩美、山崎 裕
    • Journal Title

      北海道歯誌

      Volume: 39 Pages: 146-150

    • NAID

      120006606621

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 同種造血幹細胞移植における味覚閾値の縦断的調査に関する研究2020

    • Author(s)
      松下貴惠、新井絵里、山崎 裕
    • Organizer
      日本臨床栄養代謝学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 造血幹細胞移植患者における味覚障害の検討(第2報))2019

    • Author(s)
      松下貴惠、岩島佑希、尾崎公哉、三浦和仁、山崎 裕
    • Organizer
      日本口腔内科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高齢者同種造血幹細胞移植症例における口腔粘膜炎の検討2019

    • Author(s)
      谷脇裕人、中澤誠多朗、新井絵里、尾崎公哉、岩島佑希、松下貴惠、岡田和隆、山崎 裕
    • Organizer
      日本老年歯科医学会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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