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Chlorine dioxide against hospital-acquired pneumonia, tits prophylaxis effect and safety

Research Project

Project/Area Number 18K10012
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58010:Medical management and medical sociology-related
Research InstitutionJuntendo University

Principal Investigator

Obinata Kaoru  順天堂大学, 医学部, 客員教授 (10204281)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2021: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords二酸化塩素 / 感染症対策 / 院内感染症 / 院内感染予防 / 院内感染 / 院内肺炎 / エアロゾル感染 / 環境感染対策 / 薬剤耐性菌 / 接触感染
Outline of Final Research Achievements

Infectious diseases that are rapidly transmitted via airborne or aerosol in the community space, are serious problems. Ozone and chlorine dioxide are used in practical disinfection methods of room air to prevent aerosol infections. However, a relatively high concentration of ozone is required for this purpose, which may be toxic to humans in the room. Conversely, low concentrations of chlorine dioxide gas and aqueous solution are sufficiently effective against aerosol infection of the causative microorganism, and it is expected that, when used in combination with a high-efficiency particulate air filter, it will be highly safe with a high prevention effect and cost-effectiveness.

Academic Significance and Societal Importance of the Research Achievements

二酸化塩素ガスによるエアロゾル感染、水溶液による接触感染に対する抑制効果は基礎研究で確認されている。安全性についても問題ないことから人的、経済的に負担の少ない新たな院内感染の対策として利用できる。二酸化塩素ガス発生装置を病室内に設置することにより、人的な負担なく有効な微生物の低減効果が得られる。さらにHEPAフィルターと併用することにより感染予防効果が更に向上すると考えられ、二酸化塩素は院内感染にも優れた感染予防策である。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2022 2021 2020 2019 2018

All Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] New countermeasures against infection with/after COVID-19: Is chloride a useful and safe disinfectant?dioxide a useful2022

    • Author(s)
      Kaoru Obinata
    • Journal Title

      Juntendo Medical Journal

      Volume: 68 Pages: 465-472

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chlorine dioxide combats infections. Examination of preventive effect and safety of chlorine dioxide on nosocomial pneumonia2021

    • Author(s)
      Obinata K
    • Journal Title

      Impact Science

      Volume: 6 Pages: 37-39

    • Related Report
      2021 Research-status Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Pertussis Transmission in a Hospital Office that was Confirmed on the Basis of Loop-mediated Isothermal Amplification2021

    • Author(s)
      Niizuma T, Obinata K, Kinoshita K, Shimizu T
    • Journal Title

      Juntendo Medical Journal

      Volume: 67

    • NAID

      130008081065

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluating nocturnal polyuria in Japanese children with nocturnal enuresis2021

    • Author(s)
      Nishizaki N, Hara T, Obinata K, Shimizu T
    • Journal Title

      Pediatr Int

      Volume: 63 Pages: 1339-1343

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polymyxin b-immobilized fiber column direct hemoperfusion for micro-preemie infants: Is extended duration better than early start?2021

    • Author(s)
      Nishizaki N, Obinata K, Shimizu T
    • Journal Title

      Blood Purif

      Volume: - Issue: 5 Pages: 472-474

    • DOI

      10.1159/000518231

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 冬季における感染性胃腸炎入院患者のマルチプレックスPCR法による原因微生物解析2021

    • Author(s)
      鈴木恭子、新妻隆広、海老原慎介、木下恵司、大日方薫、清水俊明
    • Journal Title

      日本小児栄養消化器肝臓病学会雑誌

      Volume: 35 Pages: 1-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of continuous renal replacement therapy with the AN69ST membrane for septic shock and sepsis-induced AKI in an infant: a case report with literature review of cytokine/mediator removal therapy in children2020

    • Author(s)
      Nishizaki N, Ueno R, Nagayama Y, Abe H, Matsuda A, Obinata K, Okazaki T, Shimizu T
    • Journal Title

      Renal Replacement Therapy

      Volume: 6:34 Pages: 2-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic usefulness of loop-mediated isothermal amplification for intrafamilial pertussis infection2020

    • Author(s)
      Niizuma,T, Obinata K, Kinoshita K, Shinizu T
    • Journal Title

      Juntendo Medical Journal

      Volume: 66 Pages: 231-236

    • NAID

      130007866984

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validation of PCR-based testing for surveillance of drug resistant Acinetobacter baumannii(ISAbal/blaOXA-51-like) in a pediatric wardi2018

    • Author(s)
      Imoto N, Obinata K, Nakazawa T, Sasaki S
    • Journal Title

      Juntendo Medical Journal

      Volume: 64 Pages: 461-467

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 小児呼吸器感染症診療ガイドライン2018

    • Author(s)
      大日方 薫
    • Journal Title

      小児科

      Volume: 59 Pages: 1227-1233

    • Related Report
      2018 Research-status Report
  • [Presentation] COVID-19後に小児多系統炎症性症候群および川崎病様症状を呈した小児例2021

    • Author(s)
      106.若盛ゆき音, 新妻隆広, 米山俊之, 嶋 泰樹,織田久之,大日方 薫
    • Organizer
      第95回 日本感染症学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 関連3施設における極低出生体重児の遅発型敗血症の傾向2020

    • Author(s)
      笠井悠里葉、久田 研、遠山雄大、中野紗季、五十嵐成、小松充孝、大川夏紀、西崎直人、寒竹正人、大日方薫、清水俊明
    • Organizer
      第52回 日本小児感染症学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 早産児敗血症ショックに対するメディエーター除去療法の有用性と転帰に関する検討2020

    • Author(s)
      西崎直人、松田明奈、水谷亮、中川真由、大日方薫、清水俊明
    • Organizer
      第52回 日本小児感染症学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 小児呼吸器感染症におけるmultiplex PCR法を用いた原因微生物の検討2019

    • Author(s)
      坂野万里子、新妻隆広、笠井悠里葉、大日方薫、清水俊明
    • Organizer
      第51回 日本小児感染症学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 2018年以降の当院における百日咳届け症例の検討2019

    • Author(s)
      新妻隆広、大日方薫、笠井悠里葉、鈴木恭子、清水俊明
    • Organizer
      第51回 日本小児感染症学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 乳幼児突然死症候群2例における呼吸器ウイルス感染2019

    • Author(s)
      新妻隆広、大日方薫
    • Organizer
      第60回 日本臨床ウイルス学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Validation of PCR-based testing for surveillance of drug resistant Acinetobacter baumannii(ISAbal/blaOXA-51-like) in a pediatric wardi2018

    • Author(s)
      Imoto N, Obinata K, Nakazawa T, Sasaki S
    • Organizer
      The 9th Asian Congress of Pediatric Infectious Diseases
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 2016/2017,2017/2018シーズンにおける冬季感染性胃腸炎入院患者のマルチプレックスPCR法による原因微生物解析2018

    • Author(s)
      鈴木恭子、新妻隆広、木下恵司、大日方 薫
    • Organizer
      第50回日本小児感染症学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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