| Project/Area Number |
18K10013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58010:Medical management and medical sociology-related
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 薬剤耐性菌 / 人畜共通感染症 / Covid-19 / エアロゾル感染 / COVID-19 / 空気感染 / ESBL / SARS-Cov-2 / SARS-CoV-2 / 人畜共通感染 / Campylobacter / 間接的接触感染 / one health / ESBL産生菌 / 薬剤耐性菌（AMR） / 人・動物・環境 / 数理モデル / One health |
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| Outline of Final Research Achievements |
We estimated the risk of resistant bacteria or resistance determinants caused by the use of antibacterial agents in animals infecting humans via the meat of food-producing animals, including Campylobacter jejuni/coli in chicken meat. A review of the literature regarding the risk of infection from community-based ESBL-producing E. coli. As the novel coronavirus was recognized to be prevalent in Japan in 2020, priority was given to supporting university hospitals' countermeasures against the novel coronavirus and research on the novel coronavirus, which is a zoonotic disease. We were conducting joint research with the Department of Anesthesiology of our School of Medicine regarding the risk of infection measures to prevent aerosol generation during intubation of COVID-19 patients. The infection risk through the mouth, nose, and eye mucous membranes due to hand contact with environmental surfaces was investigated, and the risk of aerosol infection by the model also was examined.
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| Academic Significance and Societal Importance of the Research Achievements |
環境からの間接的な接触感染、眼からの感染リスクに関する研究は多くなく、6件の論文に引用されている。プラスチック製のエアロゾルボックスとビニール製の覆いに関する比較実験の共同研究で、ビニール製の覆いの方が周囲の汚染 が低い可能性を示した。この結果の報告が、J. Clin. Anesth. 2021に掲載され、資源の乏しい途上国でも利用可能なもので有用と考えられた。エアロゾル感染リスクの推定では、感受性者のマスクだけでなく、換気の併用が重要であることを示せた。研究期間が新型コロナ禍と重なり、薬剤耐性菌の発生メカニズムにも影響をもたらした可能性があり、文献調査であるが検討を行った。
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