Epigenetic effect of prenatal exposure to perfluoroalkyl substances on fetal development and later-long health
| Project/Area Number |
18K10022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | Hokkaido University |
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Principal Investigator |
Miura Ryu 北海道大学, 環境健康科学研究教育センター, 客員研究員 (20506414)
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| Co-Investigator(Kenkyū-buntansha) |
岸 玲子 北海道大学, 環境健康科学研究教育センター, センター特別招へい教授 (80112449)
宮下 ちひろ 北海道大学, 環境健康科学研究教育センター, 特任准教授 (70632389)
湊屋 街子 北海道大学, 環境健康科学研究教育センター, 客員研究員 (50733367)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 有機フッ素化合物 / エピジェネティクス / DNAメチル化 / 胎児期曝露 / 発育体格 / 臍帯血 / 環境疫学 / 肥満・発育異常 / 出生コホート |
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| Outline of Final Research Achievements |
We examined the associations of obesity tendency at 12 years of age with prenatal exposure to Perfluoroalkyl substances (PFASs) and genome-wide DNA methylation changes in cord blood. Of the 8 PFASs analyzed, perfluorooctanoic acid (PFOA) were inversely associated with obesity tendency (per log10-unit: odds ratio (R)=0.23, 95% confidence intervals (95% CI), 0.06 to 0.89). While, in adjusted robust linear regression models, there was no CpG with significant epigenome-wide methylation alteration (FDR q-value < 0.05). In a previous study, we found a PFOA associated-down methylation region on the GFPT2 gene, which is suggested to be associated with adiposity in childhood. However, no significant association between methylation levels at CpG sites on t the GFPT2 gene and obesity tendency was found.
We are currently conducting exposure measurements to investigate in detail the association with DNA methylation changes, childhood obesity, and prenatal PFASs exposure.
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| Academic Significance and Societal Importance of the Research Achievements |
母体の環境要因によるエピゲノム変化が次世代の健康リスクの上昇・低下に関与するため、エピゲノムを介したメカニズムを解明することは環境化学物質のリスク評価および疾病予防にとって重要である。
本研究は、難燃剤などで多用される有機フッ素系化学物質の胎児期曝露に起因する臍帯血DNAのメチル化変化を介して、曝露が児の発育・成長に与える影響を出生前向きコホート研究により明らかにすることを目的とする。エピゲノムを介した胎児期環境による健康影響を引き起こすメカニズムが解明されれば、次世代の健康リスクの軽減や影響を減らすことに大きく貢献できる。
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children’s Health.2021
Author(s)
Miyake K, Miyashita C, Araki A, Miura R, Itoh S, Yamazaki K, Kobayashi S, Masuda H, Ooka T, Yamagata Z, Kishi R
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Journal Title
Clinical Epigenetics
Volume: in press
Related Report
Peer Reviewed
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