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Establishment of a detection system for antiviral-resistant influenza viruses

Research Project

Project/Area Number 18K10036
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Takashita Emi  国立感染症研究所, インフルエンザ・呼吸器系ウイルス研究センター, 主任研究官 (30361249)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsインフルエンザ / 抗インフルエンザ薬 / 薬剤耐性ウイルス / 薬剤耐性 / インフルエンザウイルス
Outline of Final Research Achievements

This study aimed to establish a detection system and surveillance framework for antiviral-resistant influenza viruses, specifically targeting resistance to the novel anti-influenza drug baloxavir marboxil developed in Japan. The research successfully developed a system for rapid detection of baloxavir-resistant viruses and provided a mechanism for timely dissemination of information to communities and medical institutions. In addition, using the detection system established in this study, we screened circulating viruses in Japan and identified human-to-human transmission of baloxavir-resistant viruses.

Academic Significance and Societal Importance of the Research Achievements

キャップ依存性エンドヌクレアーゼ阻害剤バロキサビル マルボキシルは、日本国内で開発された新規抗インフルエンザ薬で、2018年2月に世界に先駆けて日本で承認された。本研究ではバロキサビルに対する耐性ウイルスの検出系を構築し、耐性ウイルスの監視体制を確立した。
耐性ウイルスの発生状況を迅速に把握し、自治体および医療機関に速やかに情報提供することは公衆衛生上極めて重要である。本研究で確立した監視体制は、耐性ウイルスの感染拡大を防ぐための早期対策を可能にし、流行を効果的に制御するための基盤となる。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (58 results)

All 2023 2022 2021 2020 2019 2018 Other

All Journal Article (24 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 20 results,  Open Access: 21 results) Presentation (23 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results) Book (7 results) Remarks (4 results)

  • [Journal Article] A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 20232023

    • Author(s)
      Takashita Emi、Fujisaki Seiichiro、Morita Hiroko、Nagata Shiho、Miura Hideka、Matsuura Yuki、Yamamoto Saya、Chiba Shoko、Inoue Yumiko、Minami Iori、Yoshikawa Sayaka、Yamazaki Seiko、Kishida Noriko、Nakamura Kazuya、Shirakura Masayuki、Watanabe Shinji、Hasegawa Hideki
    • Journal Title

      Eurosurveillance

      Volume: 28 Issue: 39 Pages: 2300501-2300501

    • DOI

      10.2807/1560-7917.es.2023.28.39.2300501

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical And Virologic Impacts of Respiratory Viral Co-infections in Children With Influenza2023

    • Author(s)
      Sato Masatoki、Takashita Emi、Katayose Masahiko、Nemoto Kenji、Sakai Nobuko、Fujisaki Seiichiro、Hashimoto Koichi、Hosoya Mitsuaki
    • Journal Title

      Pediatric Infectious Disease Journal

      Volume: Publish Ahead of Print Issue: 8 Pages: 0000-0000

    • DOI

      10.1097/inf.0000000000003940

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of the frequency of SARS-CoV-2 Omicron variant escape from RNA-dependent RNA polymerase inhibitors and 3C-like protease inhibitors2023

    • Author(s)
      Takashita Emi、Fujisaki Seiichiro、Morita Hiroko、Nagata Shiho、Miura Hideka、Nagashima Mami、Watanabe Shinji、Takeda Makoto、Kawaoka Yoshihiro、Hasegawa Hideki
    • Journal Title

      Antiviral Research

      Volume: 216 Pages: 105671-105671

    • DOI

      10.1016/j.antiviral.2023.105671

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antiviral Susceptibilities of Distinct Lineages of Influenza C and D Viruses2023

    • Author(s)
      Takashita Emi、Murakami Shin、Matsuzaki Yoko、Fujisaki Seiichiro、Morita Hiroko、Nagata Shiho、Katayama Misa、Mizuta Katsumi、Nishimura Hidekazu、Watanabe Shinji、Horimoto Taisuke、Hasegawa Hideki
    • Journal Title

      Viruses

      Volume: 15 Issue: 1 Pages: 244-244

    • DOI

      10.3390/v15010244

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antiviral Susceptibilities of Avian Influenza A(H5), A(H7), and A(H9) Viruses Isolated in Japan2022

    • Author(s)
      Takashita Emi、Morita Hiroko、Nagata Shiho、Shirakura Masayuki、Fujisaki Seiichiro、Miura Hideka、Takayama Ikuyo、Arita Tomoko、Suzuki Yasushi、Yamaoka Masaoki、Tanikawa Taichiro、Tsunekuni Ryota、Mine Junki、Sakuma Saki、Uchida Yuko、Shibata Akihiro、Iwanaka Mari、Kishida Noriko、Nakamura Kazuya et al.
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 75 Issue: 4 Pages: 398-402

    • DOI

      10.7883/yoken.JJID.2021.751

    • NAID

      130008136488

    • ISSN
      1344-6304, 1884-2836
    • Year and Date
      2022-07-31
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2018?20202022

    • Author(s)
      Govorkova EA, Takashita E, Daniels RS, Fujisaki S, Presser LD, Patel MC, Huang W, Lackenby A, Nguyen HT, Pereyaslov D, Rattigan A, Brown SK, Samaan M, Subbarao K, Wong S, Wang D, Webby RJ, Yen HL, Zhang W, Meijer A, Gubareva LV
    • Journal Title

      Antiviral Research

      Volume: 200 Pages: 105281-105281

    • DOI

      10.1016/j.antiviral.2022.105281

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assays for Determining the Sialidase Activity of Influenza Viruses and Monitoring Influenza Virus Susceptibility to Neuraminidase Inhibitors2022

    • Author(s)
      Takashita Emi
    • Journal Title

      Methods Mol Biol

      Volume: - Pages: 287-302

    • DOI

      10.1007/978-1-0716-2635-1_19

    • ISBN
      9781071626344, 9781071626351
    • Related Report
      2022 Research-status Report
  • [Journal Article] Are twindemics occurring?2022

    • Author(s)
      Takashita Emi、Watanabe Shinji、Hasegawa Hideki、Kawaoka Yoshihiro
    • Journal Title

      Influenza and Other Respiratory Viruses

      Volume: 17 Issue: 1

    • DOI

      10.1111/irv.13090

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group2021

    • Author(s)
      Ison Michael G.、Hayden Frederick G.、Hay Alan J.、Gubareva Larisa V.、Govorkova Elena A.、Takashita Emi、McKimm-Breschkin Jennifer L.
    • Journal Title

      Antiviral Research

      Volume: 194 Pages: 105158-105158

    • DOI

      10.1016/j.antiviral.2021.105158

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of variants with reduced baloxavir marboxil and oseltamivir susceptibility in children with influenza A during the 2019-2020 influenza season2021

    • Author(s)
      Sato Masatoki、Takashita Emi、Katayose Masahiko、Nemoto Kenji、Sakai Nobuko、Fujisaki Seiichiro、Hashimoto Koichi、Hosoya Mitsuaki
    • Journal Title

      The Journal of Infectious Diseases

      Volume: - Pages: 1735-1741

    • DOI

      10.1093/infdis/jiab196

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of a Peramivir-Resistant Influenza B/Yamagata-Lineage Virus Imported from Indonesia in Aichi, Japan, March 20192020

    • Author(s)
      Takashita Emi、Yasui Yoshihiro、Nagata Shiho、Morita Hiroko、Fujisaki Seiichiro、Miura Hideka、Shirakura Masayuki、Kishida Noriko、Nakamura Kazuya、Kuwahara Tomoko、Sugawara Hiromi、Sato Aya、Akimoto Miki、Kaido Tatsuya、Watanabe Shinji、Hasegawa Hideki、The Influenza Virus Surveillance Group of Japan
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 73 Issue: 5 Pages: 386-390

    • DOI

      10.7883/yoken.jjid.2020.084

    • NAID

      130007907185

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influenza A(H1N1)pdm09 virus exhibiting reduced susceptibility to baloxavir due to a PA E23K substitution detected from a child without baloxavir treatment2020

    • Author(s)
      Takashita Emi、Abe Takashi、Morita Hiroko、Nagata Shiho、Fujisaki Seiichiro、Miura Hideka、Shirakura Masayuki、Kishida Noriko、Nakamura Kazuya、Kuwahara Tomoko、Mitamura Keiko、Ichikawa Masataka、Yamazaki Masahiko、Watanabe Shinji、Hasegawa Hideki et al.
    • Journal Title

      Antiviral Research

      Volume: 180 Pages: 104828-104828

    • DOI

      10.1016/j.antiviral.2020.104828

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In Vitro Characterization of Multidrug-Resistant Influenza A(H1N1)pdm09 Viruses Carrying a Dual Neuraminidase Mutation Isolated from Immunocompromised Patients2020

    • Author(s)
      Takashita Emi、Fujisaki Seiichiro、Yokoyama Masaru、Shirakura Masayuki、Morita Hiroko、Nakamura Kazuya、Kishida Noriko、Kuwahara Tomoko、Sato Hironori、Doi Ikuko、Sato Yuji、Takao Shinichi、Shimazu Yukie、Shimomura Takeshi、Ito Takuo、Watanabe Shinji、Odagiri Takato et al.
    • Journal Title

      Pathogens

      Volume: 9 Issue: 9 Pages: 725-725

    • DOI

      10.3390/pathogens9090725

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] グローバル視点からみるインフルエンザの動向について教えてください2020

    • Author(s)
      高下恵美
    • Journal Title

      up-to-date 子どもの感染症

      Volume: 8 Pages: 10-11

    • Related Report
      2020 Research-status Report
  • [Journal Article] バロキサビル マルボキシルは、NA阻害薬耐性株に対しても有効なのでしょうか2020

    • Author(s)
      高下恵美
    • Journal Title

      インフルエンザ~その他の呼吸器感染症

      Volume: 70 Pages: 42-42

    • Related Report
      2020 Research-status Report
  • [Journal Article] Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017?20182020

    • Author(s)
      Takashita Emi、Daniels Rod S.、Fujisaki Seiichiro、Gregory Vicki、Gubareva Larisa V.、Huang Weiijuan、Hurt Aeron C.、Lackenby Angie、Nguyen Ha T.、Pereyaslov Dmitriy、Roe Merryn、Samaan Magdi、Subbarao Kanta、Tse Herman、Wang Dayan、Yen Hui-Ling、Zhang Wenqing、Meijer Adam
    • Journal Title

      Antiviral Research

      Volume: 175 Pages: 104718-104718

    • DOI

      10.1016/j.antiviral.2020.104718

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of Variants With Reduced Baloxavir Marboxil Susceptibility After Treatment of Children With Influenza A During the 2018?2019 Influenza Season2020

    • Author(s)
      Sato Masatoki、Takashita Emi、Katayose Masahiko、Nemoto Kenji、Sakai Nobuko、Hashimoto Koichi、Hosoya Mitsuaki
    • Journal Title

      The Journal of Infectious Diseases

      Volume: - Issue: 1 Pages: 121-125

    • DOI

      10.1093/infdis/jiaa061

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid detection of an I38T amino acid substitution in influenza polymerase acidic subunit associated with reduced susceptibility to baloxavir marboxil2020

    • Author(s)
      Nakauchi Mina、Takashita Emi、Fujisaki Seiichiro、Shirakura Masayuki、Ogawa Rie、Morita Hiroko、Miura Hideka、Saito Shinji、Watanabe Shinji、Odagiri Takato、Kageyama Tsutomu
    • Journal Title

      Influenza and Other Respiratory Viruses

      Volume: - Issue: 4 Pages: 436-443

    • DOI

      10.1111/irv.12728

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influenza Polymerase Inhibitors: Mechanisms of Action and Resistance2020

    • Author(s)
      Takashita Emi
    • Journal Title

      Cold Spring Harbor Perspectives in Medicine

      Volume: - Issue: 5 Pages: a038687-a038687

    • DOI

      10.1101/cshperspect.a038687

    • Related Report
      2019 Research-status Report
    • Open Access
  • [Journal Article] Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 20192019

    • Author(s)
      Takashita Emi、Ichikawa Masataka、Morita Hiroko、Ogawa Rie、Fujisaki Seiichiro、Shirakura Masayuki、Miura Hideka、Nakamura Kazuya、Kishida Noriko、Kuwahara Tomoko、Sugawara Hiromi、Sato Aya、Akimoto Miki、Mitamura Keiko、Abe Takashi、Yamazaki Masahiko、Watanabe Shinji、Hasegawa Hideki、Odagiri Takato
    • Journal Title

      Emerging Infectious Diseases

      Volume: 25 Issue: 11 Pages: 2108-2111

    • DOI

      10.3201/eid2511.190757

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018.2019

    • Author(s)
      Takashita E, Kawakami C, Morita H, Ogawa R, Fujisaki S, Shirakura M, Miura H, Nakamura K, Kishida N, Kuwahara T, Mitamura K, Abe T, Ichikawa M, Yamazaki M, Watanabe S, Odagiri T, On Behalf Of The Influenza Virus Surveillance Group Of Japan.
    • Journal Title

      Euro Surveill.

      Volume: 24 Issue: 3 Pages: 1800698-1800698

    • DOI

      10.2807/1560-7917.es.2019.24.3.1800698

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.2019

    • Author(s)
      Takashita E, Kawakami C, Ogawa R, Morita H, Fujisaki S, Shirakura M, Miura H, Nakamura K, Kishida N, Kuwahara T, Ota A, Togashi H, Saito A, Mitamura K, Abe T, Ichikawa M, Yamazaki M, Watanabe S, Odagiri T.
    • Journal Title

      Euro Surveill.

      Volume: 24 Issue: 12 Pages: 1900170-1900170

    • DOI

      10.2807/1560-7917.es.2019.24.12.1900170

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors and status of novel antivirals, 2016-2017.2018

    • Author(s)
      Lackenby A, Besselaar TG, Daniels RS, Fry A, Gregory V, Gubareva LV, Huang W, Hurt AC, Leang SK, Lee RTC, Lo J, Lollis L, Maurer-Stroh S, Odagiri T, Pereyaslov D, Takashita E, Wang D, Zhang W, Meijer A.
    • Journal Title

      Antiviral Res.

      Volume: 157 Pages: 38-46

    • DOI

      10.1016/j.antiviral.2018.07.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Susceptibility of Influenza Viruses to the Novel Cap-Dependent Endonuclease Inhibitor Baloxavir Marboxil.2018

    • Author(s)
      Takashita E, Morita H, Ogawa R, Nakamura K, Fujisaki S, Shirakura M, Kuwahara T, Kishida N, Watanabe S, Odagiri T.
    • Journal Title

      Front Microbiol.

      Volume: 9 Pages: 3026-3026

    • DOI

      10.3389/fmicb.2018.03026

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 2022/23インフルエンザシーズンにおける薬剤未投与例からのバロキサビル耐性変異ウイルスの検出2023

    • Author(s)
      高下恵美
    • Organizer
      第55回日本小児感染症学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] SARS-CoV-2 resistance to antibodies and protease inhibitors2023

    • Author(s)
      Emi Takashita
    • Organizer
      The 2nd isirv Antiviral Group Webinar Series
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 2021/22シーズンに横浜市で分離したAH3インフルエンザウイルスの解析2022

    • Author(s)
      川上千春、清水耕平、小澤広規、宇宿秀三、大久保一郎、高下恵美、藤崎誠一郎、岸田典子、中村一哉、渡邉真治
    • Organizer
      第35回インフルエンザ研究者交流の会シンポジウム
    • Related Report
      2022 Research-status Report
  • [Presentation] SARS-CoV-2に対するCOVID-19治療薬の効果について2022

    • Author(s)
      高下恵美
    • Organizer
      第89回日本呼吸器学会・日本結核 非結核性抗酸菌症学会・日本サルコイドーシス/肉芽腫性疾患学会 九州支部秋季学術講演会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] COVID-19流行下における小児のライノウイルス感染リスクの上昇2022

    • Author(s)
      高下恵美
    • Organizer
      第125回日本小児科学会学術集会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 新型コロナウイルス感染症流行下における小児のライノウイルス感染リスクの上昇2021

    • Author(s)
      高下恵美、川上千春、百木智子、七種美和子、清水耕平、小澤広規、熊崎真琴、宇宿秀三、田中伸子、大久保一郎、森田博子、永田志保、渡邉真治、長谷川秀樹、河岡義裕
    • Organizer
      第34回インフルエンザ研究者交流の会シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] 2017/18 シーズンから2019/20 シーズンに流行したAH1pdm09 インフルエンザウイルスの解析2021

    • Author(s)
      川上千春、百木智子、七種美和子、清水耕平、小澤広規、宇宿秀三、田中伸子、大久保一郎、高下恵美、藤崎誠一郎、中村一哉、岸田典子、渡邉真治、長谷川秀樹
    • Organizer
      第34回インフルエンザ研究者交流の会シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] 新型コロナウイルス感染症流行下における小児のライノウイルス感染リスクの上昇2021

    • Author(s)
      高下恵美、川上千春、百木智子、七種美和子、清水耕平、小澤広規、熊崎真琴、宇宿秀三、田中伸子、大久保一郎、森田博子、永田志保、渡邉真治、長谷川秀樹、河岡義裕
    • Organizer
      第53回小児感染症学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Increased risk of rhinovirus infection in children during the coronavirus disease-19 pandemic2021

    • Author(s)
      Takashita E, Kawakami C, Momoki T, Saikusa M, Shimizu K, Ozawa H, Kumazaki M, Usuku S, Tanaka N, Okubo I, Morita H, Nagata S, Watanabe S, Hasegawa H, Kawaoka Y
    • Organizer
      ISIRV-WHO Virtual Conference: COVID-19, Influenza and RSV: Surveillance-Informed Prevention and Treatment
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新型コロナウイルス感染症流行下における小児のライノウイルス感染リスクの上昇2021

    • Author(s)
      高下恵美、川上千春、百木智子、七種美和子、清水耕平、小澤広規、熊崎真琴、宇宿秀三、田中伸子、大久保一郎、森田博子、永田志保、渡邉真治、長谷川秀樹、河岡義裕
    • Organizer
      第68回日本ウイルス学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Characterizations of circulating influenza viruses in the 2020/21 season and selection of vaccine viruses for the 2021/22 season2021

    • Author(s)
      Watanabe S, Nakamura K, Kishida N, Fujisaki S, Shirakura M, Takashita E, T Kuwahara, Sato A, Akimoto M, Miura H, Morita H, Sugawara H, Hasegawa, H The influenza surveillance group of Japan
    • Organizer
      第68回日本ウイルス学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 過去3シーズンに流行したAH1pdm09インフルエンザウイルスの解析2020

    • Author(s)
      川上千春、七種美和子、清水耕平、小澤広規、宇宿秀三、高下恵美、藤崎誠一郎、中村一哉、岸田典子、渡邉真治
    • Organizer
      第52回日本小児感染症学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Antiviral resistance: frequency of resistance, impact on patient, risk of transmission2020

    • Author(s)
      Emi Takashita
    • Organizer
      APACI 2020 Webinar Series on Pandemic Preparedness
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 2018-19シーズンにおける バロキサビル耐性変異ウイルスの検出状況2020

    • Author(s)
      高下恵美、森田博子、永田志保、藤崎誠一郎、白倉雅之、中村一哉、岸田典子、 桑原朋子、渡邉真治、長谷川秀樹
    • Organizer
      9tn Negative Strand Virus-Japan
    • Related Report
      2019 Research-status Report
  • [Presentation] 抗インフルエンザ薬 耐性株サーベイランス2019

    • Author(s)
      高下恵美
    • Organizer
      第93回日本感染症学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] インフルエンザウイルスの グローバルサーベイランス2019

    • Author(s)
      高下恵美
    • Organizer
      第60回日本臨床ウイルス学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 新規抗インフルエンザ薬 バロキサビルに対する耐性株サーベイランス2019

    • Author(s)
      高下恵美
    • Organizer
      第33回インフルエンザ研究者交流の会シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Human-to-human transmission of influenza A(H3N2) viruses exhibiting reduced susceptibility to baloxavir due to a PA I38T substitution in Japan2019

    • Author(s)
      Emi Takashita, Rie Ogawa, Hiroko Morita, Seiichiro Fujisaki, Masayuki Shirakura, Hideka Miura, Kazuya Nakamura, Noriko Kishida, Tomoko Kuwahara, Hiromi Sugawara, Aya Sato, Miki Akimoto, Keiko Mitamura, Takashi Abe, Masataka Ichikawa, Masahiko Yamazaki, Shinji Watanabe, Takato Odagiri
    • Organizer
      Options X for the Control of Influenza
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] インフルエンザウイルスの 薬剤耐性株サーベイランス2019

    • Author(s)
      高下恵美
    • Organizer
      第33回日本臨床内科医学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 2018/2019シーズンにおける新規抗インフルエンザ薬バロキサビル耐性変異ウイルスの検出状況2019

    • Author(s)
      高下恵美 藤崎誠一郎 白倉雅之 中村一哉 岸田典子 桑原朋子 三田村敬子 安倍隆 市川正孝 山崎雅彦 渡邉真治 小田切孝人 長谷川秀樹
    • Organizer
      第51回日本小児感染症学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Human-to-human transmission of influenza A(H3N2) viruses exhibiting reduced susceptibility to baloxavir due to a PA I38T substitution in Japan2019

    • Author(s)
      Emi Takashita, Hiroko Morita, Rie Ogawa, Seiichiro Fujisaki, Masayuki Shirakura, Hideka Miura, Kazuya Nakamura, Noriko Kishida, Tomoko Kuwahara, Hiromi Sugawara, Aya Sato, Miki Akimoto, Keiko Mitamura, Takashi Abe, Masataka Ichikawa, Masahiko Yamazaki, Shinji Watanabe, Takato Odagiri, Hideki Hasegawa
    • Organizer
      第67回日本ウイルス学会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新規抗インフルエンザ薬バロキサビルマルボキシルに対する耐性株サーベイランス.2019

    • Author(s)
      高下恵美, 森田博子, 小川理恵, 中村一哉, 藤崎誠一郎, 白倉雅之, 桑原朋子, 岸田典子, 三浦秀佳, 秋元未来, 佐藤彩, 菅原裕美, 渡邉真治, 小田切孝人.
    • Organizer
      8th Negative Strand Virus-Japan.
    • Related Report
      2018 Research-status Report
  • [Presentation] Susceptibility of influenza viruses to the novel cap-dependent endonuclease inhibitor baloxavir marboxil.2018

    • Author(s)
      Takashita E, Morita H, Ogawa R, Nakamura K, Fujisaki S, Shirakura M, Kuwahara T, Kishida N, Mitamura K, Abe T, Ichikawa M, Yamazaki M, Watanabe S, Odagiri T.
    • Organizer
      6th isirv Antiviral Group Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] インフルエンザ診療ガイド2023-24【電子版付】2023

    • Author(s)
      菅谷 憲夫
    • Total Pages
      210
    • Publisher
      日本医事新報社
    • ISBN
      9784784954841
    • Related Report
      2023 Annual Research Report
  • [Book] インフルエンザ/新型コロナウイルス感染症 診療ガイド2022-23【電子版付】2022

    • Author(s)
      菅谷 憲夫
    • Total Pages
      320
    • Publisher
      日本医事新報社
    • ISBN
      478495483X
    • Related Report
      2022 Research-status Report
  • [Book] 創薬研究者がこれだけは知っておきたい最新のウイルス学2021

    • Author(s)
      執筆者:101名、技術情報協会
    • Total Pages
      602
    • Publisher
      技術情報協会
    • ISBN
      9784861048555
    • Related Report
      2021 Research-status Report
  • [Book] インフルエンザ/新型コロナウイルス感染症 診療ガイド2021-22【電子版付】2021

    • Author(s)
      菅谷憲夫
    • Total Pages
      298
    • Publisher
      日本医事新報社
    • ISBN
      9784784954827
    • Related Report
      2021 Research-status Report
  • [Book] Influenza: Advances in Diagnosis and Management2021

    • Author(s)
      Jun Fujita
    • Total Pages
      229
    • Publisher
      Springer
    • ISBN
      9789811591082
    • Related Report
      2020 Research-status Report
  • [Book] 新型コロナウイルス感染症流行下のインフルエンザ診療ガイド2020-212020

    • Author(s)
      菅谷 憲夫
    • Total Pages
      258
    • Publisher
      日本医事新報社
    • ISBN
      9784784954810
    • Related Report
      2020 Research-status Report
  • [Book] インフルエンザ診療ガイド2019-20【電子版付】2019

    • Author(s)
      菅谷 憲夫
    • Total Pages
      248
    • Publisher
      日本医事新報社
    • ISBN
      9784784954803
    • Related Report
      2019 Research-status Report
  • [Remarks] 抗インフルエンザ薬耐性株サーベイランス

    • URL

      https://www.niid.go.jp/niid/ja/influ-resist.html

    • Related Report
      2023 Annual Research Report 2022 Research-status Report 2021 Research-status Report 2020 Research-status Report 2019 Research-status Report
  • [Remarks] Antiviral resistance surveillance in Japan

    • URL

      https://www.niid.go.jp/niid/en/influ-resist-e.html

    • Related Report
      2023 Annual Research Report 2022 Research-status Report 2021 Research-status Report 2020 Research-status Report 2019 Research-status Report
  • [Remarks] 抗インフルエンザ薬耐性株サーベイランス

    • URL

      http://www.nih.go.jp/niid/ja/influ-resist.html

    • Related Report
      2018 Research-status Report
  • [Remarks] Antiviral resistance surveillance in Japan

    • URL

      http://www.nih.go.jp/niid/en/influ-resist-e.html

    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2025-01-30  

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