A large-scale molecular epidemiological study to evaluate associations between dietary inflammation and cancer risk considering genetic factors

• Project/Area Number: 18K10037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: Ito Hidemi 愛知県がんセンター(研究所), がん情報・対策研究分野, 分野長 (90393123)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 食事由来の炎症 / 上部消化管リスク / 頭頚部がんリスク / 食道がんリスク / 食事由来の炎症性指標 DII / 炎症性サイトカイン遺伝子多型 / がんリスク / 食事由来の炎症性指標 / DII / 頭頚部がん / 食道がん / 持続感染 / がん / 食事由来炎症性マーカー / 炎症性サイトカイン多型

Outline of Final Research Achievements

The inflammatory potential of diet that has been shown to be associated with cancer risk. We examined the association between dietary inflammatory potential as measured by the dietary inflammatory index (DII) and cancer risk in Japan.
We performed a case-control study of upper aerodigestive tract cancer (UATC), including 1,028 cases and 3,081 age- and sex-matched controls. Conditional logistic regression models were fit to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for potential confounders. A positive association was observed between increasing DII scores and overall UATC, and across anatomic subsites. All anatomic subsites, except larynx, showed the consistently elevated risk with increasing DII score. Risks for hypopharyngeal and nasopharyngeal cancers were greatly elevated, compared to the other subsites. Those subsites with known etiological associations with persistent infection to HPV or EBV showed the largest elevation in risk.

Academic Significance and Societal Importance of the Research Achievements

本研究では、日本人を対象として初めて、DIIによって推定された食事由来の炎症上部消化管がんリスクとの関連を示すことができた。 交絡要因を考慮しても、DIIは上部消化管がんリスクとの間に統計学的有意な正の関連が認められた。この関連は、頭頸部がんと食道がんいずれにおいても一貫していた。 また、DIIスコアとの関連の強さは、部位によって異なっていた。がんの発症の重要な要因である慢性炎症に関わるウイルス感染と関連が知られている鼻咽頭がんと下咽頭がんで特にDIIとの関連が強かったことが興味深い。

Research Products

• [Journal Article] Association between Socioeconomic Status and Digestive Tract Cancers: A Case-Control Study (2020)
  • Author(s): Kawakatsu Yukino、Koyanagi Yuriko N.、Oze Isao、Kasugai Yumiko、Morioka Hisayoshi、Yamaguchi Rui、Ito Hidemi、Matsuo Keitaro
  • Journal Title: Cancers Volume: 12 Issue: 11 Pages: 3258-3258
  • DOI: 10.3390/cancers12113258
  • Peer Reviewed / Open Access
• [Journal Article] Cumulative cigarette tar exposure and lung cancer risk among Japanese smokers (2020)
  • Author(s): Shimatani K、Ito H、Matsuo K、Tajima K、Takezaki T
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 50 Issue: 9 Pages: 1009-1017
  • DOI: 10.1093/jjco/hyaa083
  • Peer Reviewed
• [Journal Article] Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan (2019)
  • Author(s): Ishikura N, Usui Y, Ito H, Kasugai Y, Oze I, Kato S, Yatabe Y, Nakamura S, Matsuo K
  • Journal Title: Ann Hematol Volume: 98(8) Issue: 8 Pages: 1981-1987
  • DOI: 10.1007/s00277-019-03721-y
  • Peer Reviewed
• [Journal Article] Revisit of an unanswered question by pooled analysis of eight cohort studies in Japan: Does cigarette smoking and alcohol drinking have interaction for the risk of esophageal cancer? (2019)
  • Author(s): Oze Isao、Charvat Hadrien、Matsuo Keitaro、Ito Hidemi、Tamakoshi Akiko、Nagata Chisato、Wada Keiko、Sugawara Yumi、Sawada Norie、Yamaji Taiki、Naito Mariko、Tanaka Keitaro、Shimazu Taichi、Mizoue Tetsuya、Tsugane Shoichiro、Inoue Manami
  • Journal Title: Cancer Medicine Volume: 8 Issue: 14 Pages: 6414-6425
  • DOI: 10.1002/cam4.2514
  • Peer Reviewed / Open Access
• [Journal Article] Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population (2019)
  • Author(s): Low Siew-Kee、Chin Yoon Ming、Ito Hidemi、Matsuo Keitaro、et al.
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 17332-17332
  • DOI: 10.1038/s41598-019-53654-9
  • NAID: 120006875665
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Smoking and Pancreatic Cancer Incidence: A Pooled Analysis of 10 Population-Based Cohort Studies in Japan (2019)
  • Author(s): Koyanagi Yuriko N.、Ito Hidemi、Matsuo Keitaro、Sugawara Yumi、Hidaka Akihisa、Sawada Norie、Wada Keiko、Nagata Chisato、Tamakoshi Akiko、Lin Yingsong、Takeuchi Taro、Kitamura Yuri、Utada Mai、Sadakane Atsuko、Mizoue Tetsuya、Naito Mariko、Tanaka Keitaro、Shimazu Taichi、Tsugane Shoichiro、Inoue Manami
  • Journal Title: Cancer Epidemiology Biomarkers & Prevention Volume: 28 Issue: 8 Pages: 1370-1378
  • DOI: 10.1158/1055-9965.epi-18-1327
  • Peer Reviewed / Open Access
• [Journal Article] The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium (2019)
  • Author(s): Ugai Tomotaka、Milne Roger L.、Ito Hidemi、et al.
  • Journal Title: Molecular Genetics & Genomic Medicine Volume: 7 Issue: 6
  • DOI: 10.1002/mgg3.707
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of germinal center-associated nuclear protein polymorphisms on breast cancer risk and prognosis in a Japanese population (2019)
  • Author(s): Kotani Haruru、Ito Hidemi、Kuwahara Kazuhiko、Kuzushima Kiyotaka、Iwata Hiroji、Tsunoda Nobuyuki、Nagino Masato、Matsuo Keitaro
  • Journal Title: Breast Cancer Volume: - Issue: 5 Pages: 562-572
  • DOI: 10.1007/s12282-019-00956-5
  • Peer Reviewed / Open Access
• [Journal Article] A functional single nucleotide polymorphism in ABCC11, rs17822931, is associated with the risk of breast cancer in Japanese (2019)
  • Author(s): Ishiguro Junko、Ito Hidemi、Tsukamoto Megumi、Iwata Hiroji、Nakagawa Hiroshi、Matsuo Keitaro
  • Journal Title: Carcinogenesis Volume: - Issue: 4 Pages: 537-543
  • DOI: 10.1093/carcin/bgz005
• [Journal Article] Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults. (2018)
  • Author(s): Abe M, Shivappa N, Ito H, Oze I, Abe T, Shimizu Y, Hasegawa Y, Kiyohara C, Nomura M, Ogawa Y, Hebert JR, Matsuo K.
  • Journal Title: Oncotarget Volume: 9 Issue: 35 Pages: 24028-24040
  • DOI: 10.18632/oncotarget.25288
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer: a replication and mediation analysis. (2018)
  • Author(s): Ishioka K, Masaoka H, Ito H, Oze I, Ito S, Tajika M, Shimizu Y, Niwa Y, Nakamura S, Matsuo K.
  • Journal Title: Gastric Cancer Volume: 印刷中 Issue: 6 Pages: 936-945
  • DOI: 10.1007/s10120-018-0823-0
  • NAID: 40021694566
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21 (2018)
  • Author(s): Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, et al.
  • Journal Title: Cancer Science Volume: 109 Issue: 12 Pages: 4015-4024
  • DOI: 10.1111/cas.13815
  • Peer Reviewed / Open Access
• [Presentation] 日本人の乳がんのリスクモデル構築と個別化予防への応用 (2018)
  • Author(s): 伊藤秀美
  • Organizer: 第77回日本癌学会学術総会