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Why epidemic period of respiraotry syncytial virus has shift to summer time?

Research Project

Project/Area Number 18K10043
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionNiigata University

Principal Investigator

Saito Reiko  新潟大学, 医歯学系, 教授 (30345524)

Co-Investigator(Kenkyū-buntansha) 菖蒲川 由郷  新潟大学, 医歯学総合研究科, 特任教授 (30621198)
阿部 貴志  新潟大学, 自然科学系, 教授 (30390628)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsRSウイルス / 流行時期 / 夏期流行 / 渡航客数 / 温暖化 / 遺伝子解析 / 沖縄 / 新型コロナウイルス / 来日渡航者数 / 気候 / 全国調査 / 新型コロナウイルス感染症 / 流行減少 / 分子疫学解析 / 臨床症状 / ウイルス量 / 海外渡航客数 / RSウイルス流行時期 / 系統地理学 / 臨床経過解析 / 流行疫学 / 分子疫学
Outline of Final Research Achievements

We examined the causes of the RSV epidemic that changed significantly from winter to summer nationwide in Japan from 2017. Epidemiological analysis strongly suggested that the significant increase in the number of overseas travelers in Japan in recent years may have caused a change of the season in the the RSV epidemic. We also conducted sample collection survey with the cooperation of clinicians from Hokkaido to Okinawa. A total of 973 samples were collected, 193 type A and 290 type B RSV. In 2018 and 2019, RSV was prevalent in Okinawa one or two months ahead of the rest of the country, and genetic analysis suggested that the Okinawan virus may have spread nationwide subsequently. In 2020, RSV was detected only in Okinawa from October to November, which was considered to be the effect of corona virus control measurements.

Academic Significance and Societal Importance of the Research Achievements

本課題を通じてRSV の流行時期の変化には、温暖化よりも、海外からの渡航客の増加の影響があることが示唆された。新型コロナ流行においても海外からの輸入感染が発端であったため、感染症が国際的な人の移動に大きく影響されることが明らかとなった。また逆に新型コロナの影響で感染対策が進み、国内外の人の移動が大きく制限されたことによって日本で RSV の流行が見られなくなり、社会的な要因の影響を大きく受けていることが示された。沖縄の流行時期が、他の地域に先駆けていること、遺伝子解析上も沖縄のウイルスが他の地域より早く出現している傾向があるため今後は日本の流行における沖縄の重要性を検討すべきである。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (12 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Int'l Joint Research] National Health Laboratory, Yangon/Sanpya General Hospital, Yangon/Pyinmana General Hospital(ミャンマー)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Shifts in the epidemic season of human respiratory syncytial virus associated with inbound overseas travelers and meteorological conditions in Japan, 2014?2017: An ecological study2021

    • Author(s)
      Wagatsuma Keita、Koolhof Iain S.、Shobugawa Yugo、Saito Reiko
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 3 Pages: e0248932-e0248932

    • DOI

      10.1371/journal.pone.0248932

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Factors Contributing to Symptom Duration and Viral Reduction in Outpatient Children With Respiratory Syncytial Virus Infection2020

    • Author(s)
      Utsunomiya Takeshi、Hibino Akinobu、Taniguchi Kiyosu、Nagai Takao、Saito Naruo、Tanabe Ikumi、Odagiri Takashi、Shobugawa Yugo、Kaneko Akira、Saito Reiko
    • Journal Title

      Pediatric Infectious Disease Journal

      Volume: Publish Ahead of Print Issue: 8 Pages: 678-683

    • DOI

      10.1097/inf.0000000000002626

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 夏に流行るRSウイルス感染症2019

    • Author(s)
      齋藤玲子 田邊郁望 Khin Thu Zar Htwe 菖蒲川由郷
    • Journal Title

      BIO Clinica

      Volume: 34 Pages: 50-53

    • Related Report
      2018 Research-status Report
  • [Journal Article] 特集 RSウイルス感染症 RSウイルスの分子疫学2018

    • Author(s)
      齋藤玲子、田邊郁望
    • Journal Title

      国立感染症研究所 病原微生物検出情報

      Volume: 39 Pages: 213-215

    • Related Report
      2018 Research-status Report
    • Open Access
  • [Presentation] Decreased human respiratory syncytial virus activity during COVID-19 pandemic in Japan associated with non-pharmaceutical measurement compared to pre- pandemic period2021

    • Author(s)
      Keita WAGATSUMA, Reiko SAITO
    • Organizer
      RSV WEBINAR SERIES
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 本邦で確認された新型コロナウイルス感染症(COVID-19)と外国人渡航客数との関連について2020

    • Author(s)
      我妻奎太、齋藤玲子
    • Organizer
      第61回日本臨床ウィルス学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] RSウイルス罹患小児における症状持続期間とウイルス排泄に影響を与える因子について2019

    • Author(s)
      宇都宮剛 長田伸夫 冨本和彦 佐野康子 加地はるみ 青木才一志 谷口清洲 中村晴奈 西藤成雄 鈴木英太郎 島田康 浜端宏英 田中敏博 永井崇雄 菖蒲川由郷 齋藤玲子
    • Organizer
      第51回日本小児感染症学会総会・学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Phylogeographic analysis of respiratory syncytial virus in Japan during 2012-20172018

    • Author(s)
      Ryosuke Ito, Akinobu Hibino, Ikumi Tanabe, Takashi Odagiri, Takashi Abe, Reiko Saito
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] RSウイルス感染症 流行状況の変化2018

    • Author(s)
      齋藤玲子
    • Organizer
      第63回日本新生児生育医学会・学術集会
    • Related Report
      2018 Research-status Report
  • [Remarks] 新潟大学医学部国際保健学教室HP

    • URL

      http://www.med.niigata-u.ac.jp/pub/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 新潟大学大学院医歯学総合研究科国際保健学分野HP

    • URL

      http://www.med.niigata-u.ac.jp/pub/

    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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