Development of novel therapy for lifestyle-related diseases of elderly

• Project/Area Number: 18K10044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: University of Toyama
• Principal Investigator: Inadera Hidekuni 富山大学, 学術研究部医学系, 教授 (10301144)
• Co-Investigator(Kenkyū-buntansha): 崔 正国 福井大学, 学術研究院医学系部門, 講師 (90572115)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 生活習慣病 / がん / 高齢者 / 天然資源

Outline of Final Research Achievements

Hyperthermia (HT) has been used as mild anticancer therapy. However, HT alone is insufficient to completely kill tumor cells and an additional agent is required to overcome. In the present study, we have screened and identified several natural compounds as an adjunctive therapy to HT to induce cell death. We also explored the molecular mechanisms involved.

Academic Significance and Societal Importance of the Research Achievements

高齢者のがん治療は、病気と共存してQOLを長く維持するという視点が重要である。天然資源由来化合物は合成化合物よりも一般的に副作用が低く、高齢者にも投与しやすい。本研究により見出したがん細胞の温熱誘発細胞死を増強する化合物の有効性について、動物実験等により検証を加えることにより、身体にやさしいがん治療法の開発が期待できる。

Research Products

• [Int'l Joint Research] Graduate School of Medicine/Henan Polytechnic University/Jiaozuo 454000(中国)
• [Journal Article] The molecular mechanism of a novel derivative of BTO-956 induced apoptosis in human myelomonocytic lymphoma. (2021)
  • Author(s): Li Y, Zhou D, Cui ZG, Sun L, Feng Q, Zakki SA, Wu CA, Inadera H.
  • Journal Title: Apoptosis Volume: 26 Issue: 3-4 Pages: 219-231
  • DOI: 10.1007/s10495-021-01664-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Melatonin sensitises shikonin-induced cancer cell death mediated by oxidative stress via inhibition of the SIRT3/SOD2-AKT pathway. (2020)
  • Author(s): Li M, Wu C, Muhammad JS, Yan D, Tsuneyama K, Hatta H, Cui ZG, Inadera H.
  • Journal Title: Redox Biol Volume: 36 Pages: 101632-101632
  • DOI: 10.1016/j.redox.2020.101632
  • NAID: 120007146109
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Melatonin triggers the anticancer potential of phenylarsine oxide via induction of apoptosis through ROS generation and JNK activation. (2020)
  • Author(s): Zakki SA, Muhammad JS, Li JL, Sun L, Li ML, Feng QW, Li YL, Cui ZG, Inadera H.
  • Journal Title: Metallomics Volume: 12 Issue: 3 Pages: 396-407
  • DOI: 10.1039/c9mt00238c
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Protective effect of dihydromyricetin on hyperthermia-induced apoptosis in human myelomonocytic lymphoma cell. (2019)
  • Author(s): Feng QW, Cui ZG, Jin YJ, Sun L, Li ML, Zakki SA, Zhou D, Inadera H.
  • Journal Title: Apoptosis Volume: 24 Issue: 3-4 Pages: 290-300
  • DOI: 10.1007/s10495-019-01518-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer. (2019)
  • Author(s): Ahmed K, Zaidi SF, Cui ZG, Zhou D, Saeed SA, Inadera H.
  • Journal Title: Oncol Lett. Volume: 18 Pages: 487-498
  • DOI: 10.3892/ol.2019.10349
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Baicalin Augments Hyperthermia-Induced Apoptosis in U937 Cells and Modulates the MAPK Pathway via ROS Generation (2018)
  • Author(s): Zakki Shahbaz?Ahmad、Cui Zheng-Guo、Sun Lu、Feng Qian-Wen、Li Meng-Ling、Inadera Hidekuni
  • Journal Title: Cellular Physiology and Biochemistry Volume: 45 Issue: 6 Pages: 2444-2460
  • DOI: 10.1159/000488263
  • Peer Reviewed / Open Access
• [Journal Article] Excessive Oxidative Stress in the Synergistic Effects of Shikonin on the Hyperthermia-Induced Apoptosis (2018)
  • Author(s): Piao JL, Jin YJ, Li ML, Zakki SA, Sun L, Feng QW, Zhou DJ, Kondo T, Cui ZG, Inadera H.
  • Journal Title: Curr Mol Med Volume: 18 Issue: 5 Pages: 322-334
  • DOI: 10.2174/1566524018666181024161704
  • Peer Reviewed / Int'l Joint Research
• [Presentation] SIRT3/SOD2の阻害を介したメラトニンによるシコニン誘発細胞死の増強. (2021)
  • Author(s): Li M, Feng FW, Li YL, Zakki SA, 平工雄介, Cui ZG, 稲寺秀邦.
  • Organizer: 第91回日本衛生学会学術総会 2021, 3,6-8, 富山.
• [Presentation] 高温誘導U937細胞アポトーシスにおけるジヒドロミリセチンの耐性効果. (2021)
  • Author(s): Feng FW, Cui ZG, Li M, Li YL, Zakki SA, 稲寺秀邦.
  • Organizer: 第91回日本衛生学会学術総会 2021, 3,6-8, 富山.
• [Presentation] Melatonin sensitizes phenylarsine oxide via induction of apoptosis and results in strong anticancer potential. (2021)
  • Author(s): Cui ZG, Zakki AS, Li M, Feng Q, Li Y, Hiraku Y, Inadera H.
  • Organizer: 第91回日本衛生学会学術総会 2021, 3,6-8, 富山.
• [Presentation] Shikonin augments hyperthermia-induced apoptosis through enhancement of oxidative stress. (2019)
  • Author(s): Cui ZG, JinYJ, Zakki SA, Sun L, Li ML, Feng QW, Inadera H.
  • Organizer: IUTOX 15th International Congress of Toxicology, Hawaii, USA , July 15-18, 2019.
  • Int'l Joint Research
• [Presentation] 温熱誘発アポトーシスにおけるシコニンの増強効果とその分メカニズム. (2018)
  • Author(s): Cui ZG, 周徳軍, Li ML, Sun L, Zakki SA, Inadera H.
  • Organizer: 第88回日本衛生学会学術総会
• [Presentation] Dihydromyricetin による温熱誘発ヒトリンパU937 細胞アポトーシスの抑制効果. (2018)
  • Author(s): Feng Q, Cui ZG, Li ML, Jin Y, Sun L, Zakki SA, Kondo T, Inadera H.
  • Organizer: 第88回日本衛生学会学術総会