| Project/Area Number |
18K10052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
菱川 善隆 宮崎大学, 医学部, 教授 (60304276)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 重金属中毒 / ヒ素中毒 / 神経障害 / 末梢神経障害 / 感覚障害 / 神経生理 / 聴覚障害 / 神経生理学 / 神経学的所見 / 砒素中毒 |
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| Outline of Final Research Achievements |
Regarding sensory impairment, an analysis in Myanmar showed that the group with arsenic concentration in drinking water (ACDW) of 10 ppb or higher had significantly higher subjective symptoms of weakness and persistent numbness and pain. Objective neurological findings showed that the group with ACDW of 50 ppb or higher had a higher rate of pain and vibration sensation impairment. Objective peripheral neuropathy (both small and large diameter fibers) was estimated to occur at around 50 ppb of ACDW. Regarding hearing impairment, even high-concentration exposure in the Toroku area did not leave any sequelae in the long term in adults. Conversely, analysis in Myanmar suggests that even low concentrations may cause hearing impairment in children. When considering arsenic-induced neuropathy, it is necessary to carefully consider the factors of the exposed side, including age.
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| Academic Significance and Societal Importance of the Research Achievements |
飲料水ヒ素濃度と感覚障害に関しての末梢神経障害の関連を報告した。今回の研究にて、神経障害の閾値（dose-response関係）を世界で初めて示した。また、安全な飲料水のヒ素濃度はWHOが推奨する 10ppb以下が適切と思われた。ヒ素濃度の安全な閾値は年齢によって異なる可能性を示した。ヒ素による神経障害を検討する際には、曝露されるヒ素の濃度、期間以外に、年齢を含めた曝露される側の要素を十分に考慮する必要がある。
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