• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Heterogeneity of Japanese Epstein-Barr virus strains explored by viral genome sequences

Research Project

Project/Area Number 18K10057
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionTohoku Medical and Pharmaceutical University

Principal Investigator

Yajima Misako  東北医科薬科大学, 医学部, 助教 (60443131)

Co-Investigator(Kenkyū-buntansha) 神田 輝  東北医科薬科大学, 医学部, 教授 (50333472)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsEBウイルス / ゲノム塩基配列決定 / 大腸菌人工染色体 / ゲノム編集 / 多様性
Outline of Final Research Achievements

Epstein-Barr virus (EBV) establishes lifelong latent infection in the majority of healthy individuals, while it is a causative agent for various diseases. Recent studies indicate that there are substantial levels of viral genome heterogeneity among different EBV strains. However, the extent of EBV strain variation among asymptomatically infected individuals remains elusive. We cloned and sequenced EBV genomes derived from human tonsillar tissues, which are the reservoirs of asymptomatic EBV infection. Phylogenetic analyses revealed that Asian EBV strains could be divided into several distinct subgroups. EBV strains derived from nasopharyngeal carcinoma-endemic areas constitute different subgroups from a subgroup of EBV strains from non-endemic areas, including Japan. The results could be consistent with biased regional distribution of EBV-associated diseases depending on the different EBV strains colonizing different regions in Asian countries.

Academic Significance and Societal Importance of the Research Achievements

EBウイルスが関係する疾患の一部にはある特定の地域で高い発症率を示すものがあることが知られているが、なぜこのような発症率の違いがみられるのか、その理由は不明である。
本研究では、日本人の扁桃組織に潜伏感染しているEBウイルス株のゲノム塩基配列を調べ、比較解析を行った結果、日本のEBウイル株には多様性があり、日本を含む東アジアのEBウイルス株が中国南部・東南アジア地域のEBウイルス株と異なる系統に属することを明らかにした。本研究は、アジアにおけるEBウイルス株の地域分布とEBウイルス関連疾患の好発地域が一致する可能性があることを示した初めての報告である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2021 2019 2018 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] A global phylogenetic analysis of Japanese tonsil-derived Epstein-Barr virus strains using viral whole-genome cloning and long-read sequencing2021

    • Author(s)
      Yajima Misako、Kakuta Risako、Saito Yutaro、Kitaya Shiori、Toyoda Atsushi、Ikuta Kazufumi、Yasuda Jun、Ohta Nobuo、Kanda Teru
    • Journal Title

      Journal of General Virology

      Volume: 102 Issue: 3

    • DOI

      10.1099/jgv.0.001549

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficient Epstein-Barr Virus Progeny Production Mediated by Cancer-Derived LMP1 and Virally-Encoded microRNAs.2019

    • Author(s)
      Misako Yajima, Mamiko Miyata, Kazufumi Ikuta, Yasuhisa Hasegawa, Chitose Oneyama, Teru Kanda
    • Journal Title

      Microorganisms

      Volume: 7 Issue: 5 Pages: 119-119

    • DOI

      10.3390/microorganisms7050119

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epstein‐Barr virus strain variation and cancer2019

    • Author(s)
      Kanda Teru、Yajima Misako、Ikuta Kazufumi
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 4 Pages: 1132-1139

    • DOI

      10.1111/cas.13954

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid CRISPR/Cas9-Mediated Cloning of Full-Length Epstein-Barr Virus Genomes from Latently Infected Cells2018

    • Author(s)
      Misako Yajima, Kazufumi Ikuta, Teru Kanda
    • Journal Title

      Viruses

      Volume: 10 Issue: 4 Pages: 171-183

    • DOI

      10.3390/v10040171

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Whole-genome cloning of Epstein-Barr virus strains from asymptomatically infected individuals2019

    • Author(s)
      Misako Yajima, Kazufumi Ikuta, Teru Kanda
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 日本人由来「無症候感染EBウイルス株」のクローニング2019

    • Author(s)
      矢島美彩子、生田和史、神田輝
    • Organizer
      第33回ヘルペスウイルス研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Molecular phylogenetic analysis of Epstein-Barr virus isolated in Japan2018

    • Author(s)
      Misako Yajima, Kazufumi Ikuta, Teru Kanda
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Research-status Report
  • [Remarks] 東北医科薬科大学医学部微生物学教室

    • URL

      https://tmpukandalab.com/

    • Related Report
      2019 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi