• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the effects of assisted reproductive technology and maternal environmental factors on higher brain function and construction of its risk assessment system

Research Project

Project/Area Number 18K10058
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionTokai University

Principal Investigator

ENDO Hitoshi  東海大学, 医学部, 講師 (10550551)

Co-Investigator(Kenkyū-buntansha) 大和田 賢  東海大学, 医学部, 助教 (40756409)
住吉 秀明  東海大学, 医学部, 講師 (60343357)
阿部 幸一郎  東海大学, 医学部, 准教授 (90294123)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords次世代影響 / THAラット / 学習能力 / 高学習能 / 高次脳機能
Outline of Final Research Achievements

It is well known that in the development of healthy children, exposure to environmental factors during development has a significant impact on the formation of next-generation higher brain functions. However, no method has been established to evaluate the impact on next-generation learning and memory during development. Tokai High Avoider (THA) rats, which are high-learning ability model animals, were able to sensitively grasp the effects of environmental changes associated with developmental engineering technology and stress during pregnancy on the learning function of pups. It was also suggested that the maternal phenotype is a factor that supports the high learning ability of THA rats. This study suggests that THA rats will be very useful experimental model animals for assessing their effects on higher brain function.

Academic Significance and Societal Importance of the Research Achievements

健全な子供の発育において、出生前の母体環境や出生後の発育環境について注視することに大きな社会的意義がある。近年では、様々な生殖補助医療技術が急速に進歩・普及しする一方で、出生した子供の健康影響について高次脳機能の側面から評価がなされていない。本研究で得られた成果は、母体環境の変化によって引き起こされる次世代の認知機能への影響について適切に評価する方法を提案するものである。周産期ケアに対する新規かつ重要な情報提供の一助となり、次世代を担う子供たちの健やかな発育を考える上で大きな礎になるものと考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2021 2020 2019 2018 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Invited: 2 results) Remarks (2 results)

  • [Journal Article] Effect of acetamiprid on the immature murine testes.2018

    • Author(s)
      Terayama H, Qu N, Endo H, Ito M, Tsukamoto H, Umemoto K, Kawakami S, Fujino Y, Tatemichi M, Sakabe K
    • Journal Title

      Int J Environ Health Res.

      Volume: 28 (6) Issue: 6 Pages: 683-696

    • DOI

      10.1080/09603123.2018.1504897

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Tokai High Avoider (THA)ラットの高学習能を規定する因子の探索2021

    • Author(s)
      志田 侑華里、遠藤 整、大和田 賢、立道 昌幸
    • Organizer
      第91回日本衛生学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] THAラットを用いた次世代の学習能力への影響を評価する新規分子の探索2021

    • Author(s)
      志田 侑華里、遠藤 整、大和田 賢、立道 昌幸
    • Organizer
      第20回分子予防環境医学研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Tokai High Avoider (THA)ラットを用いた次世代のストレス適応の検討2020

    • Author(s)
      志田侑華里、菅琴美、遠藤整、大和田賢、立道昌幸
    • Organizer
      第90回日本衛生学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高学習能モデル動物Tokai High Avoider (THA)ラットを規定するメタボローム特性2019

    • Author(s)
      遠藤整
    • Organizer
      第26回肝細胞研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 生殖工学技術によるラットの個体復元と表現型への影響2019

    • Author(s)
      遠藤整
    • Organizer
      日本実験動物技術者協会関東支部 REG部会第20回特別講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 次世代影響評価における THA ラットの有用性の検討2019

    • Author(s)
      志田侑華里、遠藤整、大和田賢、古屋博行、立道昌幸
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Research-status Report
  • [Remarks] 東海大学医学部基盤診療学系 衛生学公衆衛生学HP

    • URL

      http://health.med.u-tokai.ac.jp/index.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 東海大学医学部基盤診療学系 衛生学公衆衛生学HP

    • URL

      http://health.med.u-tokai.ac.jp/index.html

    • Related Report
      2019 Research-status Report 2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi