Physical Activity Recommended as a Preventive Measure for Chronic Kidney Disease

• Project/Area Number: 18K10090
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Hokkaido Bunkyo University
• Principal Investigator: Sasaki Sachiko 北海道文教大学, 人間科学部, 准教授 (10612294)
• Co-Investigator(Kenkyū-buntansha): 中村 幸志 琉球大学, 医学(系)研究科(研究院), 教授 (80422898)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 身体活動 / 座位行動 / 慢性腎臓病 / 生活習慣

Outline of Final Research Achievements

In the present study investigated the association between indices of physical activity measured with an accelerometer and kidney function in a general Japanese population. Physical activity was assessed using an accelerometer. Kidney function was assessed using estimated glomerular filtration rate (eGFR). A linear regression model was employed to calculate the β coefficient of eGFR and logistic regression model was used to calculate the odds ratio for low eGFR (< 60 versus 60 mL/min/1.73m2) in each physical activity type.MVPA time and eGFR were positively associated in both men and women, after adjusting for age, body mass index, and other clinical characteristics . In women, sedentary behavior and eGFR were inversely associated after adjusting for the same factors . The odds ratio (95% confidence interval) for low eGFR associated with a 60-min increase in sedentary behavior was 1.65 (1.07, 2.55) after adjusting for the same factors in women.

Academic Significance and Societal Importance of the Research Achievements

慢性腎臓病 (Chronic Kidney Disease: CKD)の予防対策としては、その発症にかかわる修正可能な生活習慣要因に対して、是正・改善の取り組みを十分に行っていくことが求められている。本研究では、身体活動の種類と腎機能の低下との関連が男女間で異なる可能性を示唆しており、CKD予防対策のための生活習慣指導法の構築に新たな知見を加えるものと考える。

Research Products

• [Journal Article] Association of accelerometer-measured physical activity with kidney function in a Japanese population: the DOSANCO Health Study (2022)
  • Author(s): Sasaki S, Nakamura K, Ukawa S, Okada E, Amagasa S, Inoue S, Kimura T, Yoshimura A, Tanaka A, Nakagawa T, Imae A, Tamakoshi A.
  • Journal Title: BMC Nephrology Volume: 3 Issue: 1
  • DOI: 10.1186/s12882-021-02635-0
  • Peer Reviewed / Open Access
• [Journal Article] Are Japanese Women Less Physically Active Than Men? Findings From the DOSANCO Health Study (2021)
  • Author(s): Amagasa S., Inoue S., Ukawa S., Sasaki S., Nakamura K., Yoshimura A., Tanaka A., Kimura T., Nakagawa T., Imae A., Ding D., Kikuchi H., Tamakoshi A.
  • Journal Title: Journal of Epidemiology Volume: 31 Issue: 10 Pages: 530-536
  • DOI: 10.2188/jea.JE20200185
  • NAID: 130008101394
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2021-10-05
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations between socioeconomic status, social participation, and physical activity in older people during the COVID-19 pandemic: A cross-sectional study in a northern Japanese city. (2021)
  • Author(s): Sasaki S., Sato A., Tanabe Y., Matsuoka S., Adachi A., Kayano T., Yamazaki H., Matsuno Y., Miyake A., Watanabe T.
  • Journal Title: Journal of Environmental Health and Public Health Volume: 18(4) Issue: 4 Pages: 1477-1477
  • DOI: 10.3390/ijerph18041477
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of a new wrist-worn accelerometer with a commonly used triaxial accelerometer under free-living conditions (2018)
  • Author(s): Sachiko Sasaki, Shigekazu Ukawa, Emiko Okada, Zhao Wenjing, Tomoko Kishi, Ai Sakamoto, Akiko Tamakoshi
  • Journal Title: BMC Research Notes Volume: 11(1) Issue: 1 Pages: 746-746
  • DOI: 10.1186/s13104-018-3849-9
  • Peer Reviewed / Open Access