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Genome-wide association study and Mendelian randomization analysis focusing on sweet taste and sugar intake

Research Project

Project/Area Number 18K10095
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionYokohama City University (2020-2021)
National Cancer Center Japan (2018-2019)

Principal Investigator

Goto Atsushi  横浜市立大学, 大学院データサイエンス研究科, 教授 (80644822)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords糖質摂取量 / 糖尿病 / ゲノムワイド関連解析 / 甘味嗜好 / 単純糖質摂取量 / GWAS
Outline of Final Research Achievements

The nutritional implications of carbohydrates differ by simple and complex carbohydrates, and excessive intake of simple and complex carbohydrates is thought to lead to an increased risk of diabetes and other diseases.
In this study, we planned to find genetic factors for simple carbohydrate intake and sweet taste preferences by a genome-wide association study, but statistically significant genetic factors were not identified in the Japanese data. Therefore, we conducted a cohort study on simple sugars and starch intake in relation to the risk of type 2 diabetes without using genetic information. The results showed that in women, higher starch intake was associated with an increased risk of developing diabetes, and extremely high simple carbohydrate intake (>30% energy per day) was associated with an increased risk of developing diabetes.

Academic Significance and Societal Importance of the Research Achievements

炭水化物摂取量の違いにより、糖尿病などの慢性疾患の罹患リスクが異なると考えられているが、日本人を含むアジア人ではこの関係は検討されていなかった。本研究では、日本人女性において、でん粉の摂取量が多いと糖尿病の罹患リスク増加と関連し、単純糖質(合計単純糖質や合計果糖)の摂取が極端に多いことも、糖尿病の罹患リスク増加と関連する可能性を明らかにした。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2022 2021 2019

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Association between sugar and starch intakes and type 2 diabetes risk in middle-aged adults in a prospective cohort study2022

    • Author(s)
      Kanehara R, Goto A, Sawada N, Mizoue T, Noda M, Hida A, Iwasaki M, Tsugane S
    • Journal Title

      European Journal of Clinical Nutrition

      Volume: 76 Issue: 5 Pages: 746-755

    • DOI

      10.1038/s41430-021-01005-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Body mass index and colorectal cancer risk: A Mendelian randomization study2021

    • Author(s)
      Suzuki Shiori, Goto Atsushi, Nakatochi Masahiro, et al.
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 4 Pages: 1579-1588

    • DOI

      10.1111/cas.14824

    • NAID

      120007147665

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validity and Reproducibility of a Self-Administered Food Frequency Questionnaire for the Assessment of Sugar Intake in Middle-Aged Japanese Adults2019

    • Author(s)
      Kanehara R, Goto A, Kotemori A, Mori N, Nakamura A, Sawada N, Ishihara J, Takachi R, Kawano Y, Iwasaki M, Tsugane S
    • Journal Title

      Nutrients

      Volume: 11 Issue: 3 Pages: 554-554

    • DOI

      10.3390/nu11030554

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] メンデルランダム化は疫学の発展に貢献できるか.2021

    • Author(s)
      後藤 温
    • Organizer
      第31回日本疫学会学術総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Estimation of Sugar Intake and Validation Study for a SelfAdministered Food Frequency Questionnaire Using Urinary Sugar in Middle-Aged Japanese Adults2019

    • Author(s)
      Rieko Kanehara, Atsushi Goto, Ayaka Kotemori, Nagisa Mori, Ari Nakamura, Norie Sawada, Junko Ishihara, Ribeka Takachi, Yukari Kawano, Motoki Iwasaki, Shoichiro Tsugane
    • Organizer
      Nutrients 2019 Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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