Relationship between insulin resistance and fatty liver index in ninth-grader in Tsunan Town, Niigata, Japan

• Project/Area Number: 18K10111
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Jikei University School of Medicine
• Principal Investigator: NISHIMURA RIMEI 東京慈恵会医科大学, 医学部, 教授 (20343535)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脂肪肝指数 / インスリン抵抗性 / 小児 / 肥満 / インスリン抵抗性指数 / 疫学調査

Outline of Final Research Achievements

Obesity in adult is related with insulin resistance (IR) and fatty liver, (FL), however, little information is available in children. The study included a total of 134 ninth-grade children participating in health check-up programs in Tsunan Town, Niigata, Japan (boys/girls, 69/65), and their medians of HOMA-IR, Fatty Liver Index (FLI) and BMI were 2.6, 2.8 and 19.6 kg/m2, respectively. Those with FL accounted for a higher proportion of girls than boys, and all of them accompanied OB and IR. HOMA-IR were found to be significantly positively correlated with FLI (r=0.252、p=0.004).

Academic Significance and Societal Importance of the Research Achievements

成人においては肥満(obesity: OB)とインスリン抵抗性(insulin resistance: IR)が深く関連する。脂肪肝(fatty liver: FL)は生活習慣病のリスク因子となるが、中学生におけるFLとIRの関連について検討した報告はない。新潟県津南町にある中学3年生143名で検討したところ、HOMA-IRは肥満度/BMIとは有意な相関関係を認めなかったが、FLIと有意な相関関係を認めた(r=0.252、p=0.004)。したがって、肥満ではなく、HOMA-IRが、中学3年生における脂肪肝を予測するための指標になる可能性が示唆された。

Research Products

• [Journal Article] Eicosapentaenoic acid/arachidonic acid ratio in Japanese junior high school students (2022)
  • Author(s): Takahashi Hiroshi、Sano Hironari、Hayashi Yuusaku、Nishimura Rimei
  • Journal Title: Pediatrics International Volume: 64 Issue: 1
  • DOI: 10.1111/ped.14898
  • Peer Reviewed
• [Presentation] 中学生における脂肪肝指数とインスリン抵抗性の経時的変化と関連性の検討 (2021)
  • Author(s): 高橋 紘, 西村 理明
  • Organizer: 第64回日本糖尿病学会年次学術集会
• [Presentation] 中学生を対象としたインスリン抵抗性指数、BMI、肥満度の経時的変化の検討 (2021)
  • Author(s): 菅沼 由佳、高橋 紘, 西村 理明
  • Organizer: 第64回日本糖尿病学会年次学術集会
• [Presentation] 中学生における脂肪肝指数とインスリン抵抗性の関連性を検討する (2020)
  • Author(s): 高橋紘
  • Organizer: 第63回日本糖尿病学会年次学術集会
• [Presentation] Population-based cross-sectional study of the relationship between insulin resistance and fatty liver index in Japanese school children. (2020)
  • Author(s): Hiroshi T, Rimei N.
  • Organizer: 13th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD)
  • Int'l Joint Research