| Project/Area Number |
18K10133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58040:Forensics medicine-related
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 入浴死 / 鑑別診断 / 死因究明 / 水チャネル / 熱ショック蛋白 / 浴室内突然死 / 温水溺死モデル / DNAマイクロアレイ / アクアポリン / 疫学的解析 / 環境気温 / 入浴死警報 / 網羅的解析 / 法医分子生物学 / 温水溺死の診断 / 法医学的診断法 / 予防医学 / 死因診断 / 法医学的鑑別診断法 / 熱ショックタンパク質 / 心不全モデル |
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| Outline of Final Research Achievements |
In order to elucidate the pathology of bath-related deaths and develop a differential diagnosis, genes that fluctuate during drowning by hot water inhalation were comprehensively analyzed using DNA microarrays, and the genes that fluctuated were confirmed using quantitative RT-PCR and also examined using lung samples from forensic autopsy cases. In warm-water drowned mice, 793 genes were found to be altered in 38°C warm-water drowning and 743 genes were altered in 41°C warm-water drowning. Of these, similar results were obtained for water channel aqp5 and heat shock protein hsp90aa/ab in qRT-PCR. Furthermore, similar results were obtained in forensic autopsy samples, suggesting that they may serve as forensic diagnostic markers in cases of drowning in bathtubs.
Translated with www.DeepL.com/Translator (free version)
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で得られた成果によって浴槽内溺死の正確な診断方法の確立につながる可能性がある。これは，死因究明の新たな展開につながる可能性があり法医実務に多大な貢献をするばかりでなく，臨床現場においても浴室内から救急搬送された患者の正確な病態把握，適切な治療（二次予防）にも大きく貢献するものと考える。さらに，これまで嘱望されてきた入浴死の発生予防対策法の確立（一次予防）にもつながる可能性があり，社会への貢献度も極めて大きいといえる。
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