Intrathrombotic appearances of AQP-1 and AQP-3 in relation to thrombus age in murine deep vein thrombosis model

• Project/Area Number: 18K10134
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58040:Forensics medicine-related
• Research Institution: Wakayama Medical University
• Principal Investigator: Nosaka Mizuho 和歌山県立医科大学, 医学部, 講師 (00244731)
• Co-Investigator(Kenkyū-buntansha): 近藤 稔和 和歌山県立医科大学, 医学部, 教授 (70251923) ; 石田 裕子 和歌山県立医科大学, 医学部, 准教授 (10364077)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 深部静脈血栓症 / アクアポリン１ / アクアポリン３ / 免疫組織化学的染色 / マクロファージ / 深部静脈血栓塞栓症 / アクアポリン3 / マッソントリクローム染色 / 免疫組織化学染色 / アクアポリン / 血栓陳旧度

Outline of Final Research Achievements

Using the experimental murine model of deep vein thrombosis induced by ligation of the inferior vena cava, we performed immunohistochemical studies focusing on (1) the establishment of the new indices for determining thrombus age using Aquaporin 1 and Aquaporin 3, and (2) the application of the area of Aquaporin 1-positive regions to the evaluation of the degree of thrombus organogenesis. The results suggest that changes in the number of Aquaporin 1- and Aquaporin 3-positive cells and the distribution and area of Aquaporin 1-positive areas in thrombus cross-sections may be useful as a new index for determining thrombus aging.

Academic Significance and Societal Importance of the Research Achievements

血栓断面におけるアクアポリン１，３の分布を明確にとらえた研究は他に例を見ない．両者は今後，血栓陳旧度判定のための指標となると同時に，深部静脈血栓形成・溶解のメカニズム解明に有用であると考えられる．特に後者においては，アクアポリンが深部静脈血栓症の治療薬の開発にも貢献できる可能性があり，本症患者数が増加傾向にある現在において，重要な意義をもつ分子であると言える．またアクアポリン１は赤血球に分布することから，血栓の器質化領域の検出にも有用であり，種々の組織標本においても応用できると考えられ，より効率的な病理検査手段への足掛かりとなるものである．

Research Products

• [Journal Article] Complete decapitation by a self-constructed guillotine in a burned body ? complex suicide or postmortem burning? (2021)
  • Author(s): Ishigami A, Hata S, Ishida Y, Nosaka M, Kuninaka Y, Yamamoto H, Shimada E, Hashizume Y, Takayasu T, Kimura A, Furukawa F, Kondo T
  • Journal Title: Int J Legal Med Volume: 135 Issue: 1 Pages: 301-305
  • DOI: 10.1007/s00414-020-02323-y
  • Peer Reviewed / Open Access
• [Journal Article] Intrathrombotic appearances of AQP-1 and AQP-3 in relation to thrombus age in murine deep vein thrombosis model (2021)
  • Author(s): Nosaka M, Ishida Y, Kuninaka Y,Ishigami A, Taruya A, Shimada E, Hashizume Y, Yamamoto H, Kimura A, Furukawa F, Kondo T
  • Journal Title: Int J Legal Med Volume: 135 Issue: 2 Pages: 547-553
  • DOI: 10.1007/s00414-020-02482-y
  • Peer Reviewed / Open Access
• [Journal Article] The application of autophagy to thrombus age estimation in murine (2020)
  • Author(s): Nosaka M, Ishida Y, Kuninaka Y, Taruya A, Kimura A, Shimada E, Yamamoto H, Michiue T, Furukawa F, Kondo T
  • Journal Title: Int J Legal Med Volume: 134 Issue: 3 Pages: 1061-1066
  • DOI: 10.1007/s00414-019-02168-0
  • Peer Reviewed / Open Access
• [Journal Article] Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3?CCR5 axis (2020)
  • Author(s): Ishida Yuko、Kuninaka Yumi、Nosaka Mizuho、Kimura Akihiko、Taruya Akira、Furuta Machi、Mukaida Naofumi、Kondo Toshikazu
  • Journal Title: Nature Communications Volume: 11 Issue: 1 Pages: 1-15
  • DOI: 10.1038/s41467-020-19763-0
  • Peer Reviewed / Open Access
• [Journal Article] A case of complex suicide due to acute nicotine intoxication caused by cigarette ingestion. (2020)
  • Author(s): Yamamoto H, Takayasu T, Ishida Y, Nosaka M, Hata S, Kuninaka Y, Shimada E, Hashizume Y, Ishigami A, Ozaki M, Kawaguchi M, Kimura A, Furukawa F, Kondo T
  • Journal Title: Int J Legal Med Volume: 134 Issue: 3 Pages: 997-1002
  • DOI: 10.1007/s00414-019-02228-5
  • Peer Reviewed / Open Access
• [Journal Article] Crucial Involvement of IL-6 in Thrombus Resolution in Mice via Macrophage Recruitment and the Induction of Proteolytic Enzymes. (2020)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Taruya A, Ozaki M, Tanaka A, Mukaida N, Kondo T
  • Journal Title: Front Immunol Volume: - Pages: 3150-3150
  • DOI: 10.3389/fimmu.2019.03150
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Forensic pathological study on temporal appearance of dendritic cells in skin wounds. (2020)
  • Author(s): Kuninaka Y, Ishida Y, Nosaka M, Shimada E, Kimura A, Ozaki M, Hata S, Michiue T, Yamamoto H, Furukawa F, Eisenmenger W, Kondo T
  • Journal Title: Int J Legal Med Volume: 134 Issue: 2 Pages: 597-601
  • DOI: 10.1007/s00414-019-02185-z
  • Peer Reviewed / Open Access
• [Journal Article] Pivotal Involvement of the CX3CL1-CX3CR1 Axis for the Recruitment of M2 Tumor-Associated Macrophages in Skin Carcinogenesis. (2020)
  • Author(s): Ishida Y, Kuninaka Y, Yamamoto Y, Nosaka M, Kimura A, Furukawa F, Mukaida N, Kondo T
  • Journal Title: J Invest Dermatol Volume: - Issue: 10 Pages: 1951-1961.e6
  • DOI: 10.1016/j.jid.2020.02.023
  • Peer Reviewed / Open Access
• [Journal Article] CCL2-Mediated Reversal of Impaired Skin Wound Healing in Diabetic Mice by Normalization of Neovascularization and Collagen Accumulation. (2019)
  • Author(s): Ishida Y, Kuninaka Y, Nosaka M, Furuta M, Kimura A, Taruya A, Yamamoto H, Shimada E, Akiyama M, Mukaida N, Kondo T
  • Journal Title: J Invest Dermatol Volume: 139 Issue: 12 Pages: 2517-2527
  • DOI: 10.1016/j.jid.2019.05.022
  • Peer Reviewed / Open Access
• [Journal Article] Postmortem distribution of acephate and its metabolite methamidophos in body fluids and organ tissues of an intoxication case. (2019)
  • Author(s): Takayasu T, Yamamoto H, Ishida Y, Nosaka M, Kuninaka Y, Shimada E, Kawaguchi M, Kimura A, Kondo T
  • Journal Title: Forensic Sci Int Volume: 300 Pages: 38-43
  • DOI: 10.1016/j.forsciint.2019.02.015
  • Peer Reviewed / Open Access
• [Journal Article] Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9‐genome editing promotes antitumor immunity and suppresses ovarian cancer progression (2019)
  • Author(s): Yahata T, Mizoguchi M, Kimura A, Orimo T, Toujima S, Kuninaka Y, Nosaka M, Ishida Y, Sasaki I, Fukuda‐Ohta Y, Hemmi H, Iwahashi N, Noguchi T, Kaisho T, Kondo T, Ino K
  • Journal Title: Cancer Science Volume: 110 Issue: 4 Pages: 1279-1292
  • DOI: 10.1111/cas.13958
  • Peer Reviewed / Open Access
• [Journal Article] Sucide by plastic bag suffocation combined with the mixture of citric acid and baking soda in an adolescent (2019)
  • Author(s): Murakami K, Kawaguchi T, Hashizume Y, Kitamura K, Okada M, Okumoto K, Sakamoto S, Ishida Y, Nosaka M, Kimura A, Takatsu A, Kondo T
  • Journal Title: Int J Legal Med Volume: 133 Issue: 1 Pages: 177-180
  • DOI: 10.1007/s00414-018-1856-y
  • Peer Reviewed / Open Access
• [Journal Article] Forensic application of epidermal AQP3 expression to determination of wound vitality in human compressed neck skin (2018)
  • Author(s): Ishida Y, Kuninaka Y, Nosaka M, Shimada, Hata S, Yamamoto H, Hashizume Y, Kimura A, Furukawa F, Kondo T
  • Journal Title: Int J Legal Med Volume: 132 Issue: 5 Pages: 1375-1380
  • DOI: 10.1007/s00414-018-1780-1
  • Peer Reviewed / Open Access
• [Journal Article] Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice (2018)
  • Author(s): Mizoguchi M, Ishida Y, Nosaka M, Kimura A, Kuninaka Y, Yahata T, Nanjo S, Toujima S, Minami S, Ino K, Mukaida N, Kondo T
  • Journal Title: PLOS ONE Volume: 13 Issue: 11 Pages: e0207085-e0207085
  • DOI: 10.1371/journal.pone.0207085
  • Peer Reviewed / Open Access
• [Journal Article] Contribution of the TNF-α (Tumor Necrosis Factor-α)-TNF-Rp55 (Tumor Necrosis Factor Receptor p55) Axis in the Resolution of Venous Thrombus (2018)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Taruya A, Furuta M, Mukaida N, Kondo T
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 38 Issue: 11 Pages: 2638-2650
  • DOI: 10.1161/atvbaha.118.311194
  • Peer Reviewed / Open Access
• [Presentation] 血栓陳旧度判定に有用だったIL-6は血栓の予防・治療のための新たな標的分子となり得るか (2020)
  • Author(s): 野坂 みずほ，石田 裕子，國中 由美，石上 安希子，山本 寛記，橋爪 佑示子，島田 栄美，川口 真理子，木村 章彦，近藤 稔和
  • Organizer: 第104次日本法医学会学術全国集会
• [Presentation] マウス拘束モデルにおける胸腺萎縮へのCX3CR1の関与 (2020)
  • Author(s): 石田裕子，國中由美，野坂みずほ，石上安希子，島田栄美，山本寛記，川口真理子，近藤稔和
  • Organizer: 第104次日本法医学会学術全国集会
• [Presentation] 頸部が離断された高度焼損死体の一剖検例 (2020)
  • Author(s): 石上安希子，石田裕子，野坂みずほ，國中由美，山本寛記，島田栄美，高安達典，木村章彦，近藤稔和
  • Organizer: 第104次日本法医学会学術全国集会
• [Presentation] マウス血栓溶解におけるIL-6の役割―マクロファージとタンパク分解酵素発現の誘導― (2020)
  • Author(s): 野坂みずほ，石田裕子，石上安希子，國中由美，山本寛記，橋爪佑示子，木村章彦，向田直史，近藤稔和
  • Organizer: 第41回日本炎症・再生医学会
• [Presentation] Prevention of CaCL2-induced aortic inflammation and subsequent aneurysm formation by CCL3 (2020)
  • Author(s): 石田裕子，國中由美，野坂みずほ，木村章彦，樽谷 玲，古田眞智，向田直史，川口真理子，近藤稔和
  • Organizer: 第41回日本炎症・再生医学会
• [Presentation] CCL2-mediated reversal of impaired skin wound healing diabetic mice by normalization of neovascularization (2020)
  • Author(s): Ishida Y, Kuninaka Y, Nosaka M, Akiyama M, Mukaida N, Kawaguchi M, Kondo T
  • Organizer: 8th Annual Meeting of the International Cytokine & Interferon Society
  • Int'l Joint Research
• [Presentation] Absence of CCL5/CCR5 axis exggerates thrombus formation through reduced uPA, tPA and VEGF expression in murine DVT model (2020)
  • Author(s): Nosaka M, Ishida Y, Kuninaka Y, Ishigami A, Yamamoto H, Kimura A, Mukaida N, Kondo T
  • Organizer: 8th Annual Meeting of the International Cytokine & Interferon Society
  • Int'l Joint Research
• [Presentation] Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by CCL3 (2020)
  • Author(s): 石田 裕子，國中 由美，野坂みずほ，木村 章彦，樽谷 玲，向田 直史，近藤 稔和
  • Organizer: 第50回日本創傷治癒学会
• [Presentation] マウス深部静脈血栓の溶解におけるIL-6 の役割―マクロファージとタンパク分解酵素発現の誘導― (2020)
  • Author(s): 野坂みずほ，石田 裕子，石上安希子，國中 由美，山本 寛記，橋爪佑示子，木村 章彦，向田 直史，近藤 稔和
  • Organizer: 第50回日本創傷治癒学会
• [Presentation] 関節内ヒアルロン酸注射による壊死性筋膜炎の一剖検例 (2020)
  • Author(s): 松木順平，石上安希子，田中基就，石田裕子，野坂みずほ，山本寛記，國中由美，島田栄美，川口真理子，木村章彦，古川福実，近藤稔和
  • Organizer: 第67回日本法医学会学術近畿地方集会
• [Presentation] 複合自殺例の法医学的検討 (2020)
  • Author(s): 田中基就，橋爪佑示子，石上安希子，松木順平，石田裕子，野坂みずほ，山本寛記，國中由美，島田栄美，川口真理子，木村章彦，古川福実，近藤稔和
  • Organizer: 第67回日本法医学会学術近畿地方集会
• [Presentation] Pivotal roles of the CX3CL1-CX3CR1 axis in skin carcinogenesis (2019)
  • Author(s): Ishida Y, Kuninaka Y, Yamamoto Y, Nosaka M, Kimura A, Furukawa F, Mukaida N, Kondo T
  • Organizer: The 26th International Symposium on Molecular Cell Biology of Macrophages
• [Presentation] Intrathrombotic CX3CR1-fractalkine axis during thrombus formation and resolution through accelaration MMP2, uPA, tPA and VEGF expression on murine deep vein thrombosis model (2019)
  • Author(s): Nosaka M, Ishida Y, Kimuda A, Michiue T, Kuninaka Y, Yamamoto H, Mukaida N, Kondo T
  • Organizer: The 26th International Symposium on Molecular Cell Biology of Macrophages
• [Presentation] Pathophysiological roles of C-C chemokine receptor-5 positive macrophages in cerulein-induced acute pancreatitis (2019)
  • Author(s): Michiue T, Ishida Y, Nosaka M, Kimuda A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: The 26th International Symposium on Molecular Cell Biology of Macrophages
• [Presentation] CCL2-mediated reversal of impaired skin wound healing in diabetic mice by normalization of neovascularization (2019)
  • Author(s): Ishida Y, Kuninaka Y, Nosaka M, Akiyama M, Mukaida N, Kondo T
  • Organizer: The 26th International Symposium on Molecular Cell Biology of Macrophages
• [Presentation] セルレイン誘発急性膵炎モデルマウスを用いたケモカイン受容体CCR5の病態生理学的役割の解明 (2019)
  • Author(s): 道上知美，石田裕子，野坂みずほ，木村章彦，島田栄美，國中由美，山本寛記，川口真理子，近藤稔和
  • Organizer: 第103次日本法医学会学術全国集会
• [Presentation] 深部静脈血栓におけるCX3CR1-fractalkineの動態と法医診断学的応用に関する研究 (2019)
  • Author(s): 野坂みずほ，石田裕子，國中由美，山本寛記，道上知美，島田栄美，川口真理子，木村章彦，近藤稔和
  • Organizer: 第103次日本法医学会学術全国集会
• [Presentation] アセトアミノフェン中毒の病態形成における概日リズムの影響 (2019)
  • Author(s): 山本寛記，石田裕子，野坂みずほ，國中由美，島田栄美，道上知美，近藤稔和
  • Organizer: 第103次日本法医学会学術全国集会
• [Presentation] Pivotal roles of the CX3CL1-CX3CR1 axis in skin carcinogenesis (2019)
  • Author(s): 石田裕子，國中由美，山本有紀，野坂みずほ，木村章彦，古川福実，向田直史，近藤稔和
  • Organizer: 第40回日本炎症・再生医学会
• [Presentation] 深部静脈血栓塞栓症モデルにおけるCCR5システムの病態生理学的役割の解明 (2019)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，道上知美，山本寛記，國中由美，向田直史，近藤稔和
  • Organizer: 第40回日本炎症・再生医学会
• [Presentation] セルレイン誘発急性膵炎モデルを用いたケモカイン受容体CCR5の病態生理学役割の解明 (2019)
  • Author(s): 道上知美，石田裕子，野坂みずほ，木村章彦，國中由美，島田栄美，山本寛記，近藤稔和
  • Organizer: 第40回日本炎症・再生医学会
• [Presentation] アクアポリン動態解析による深部静脈血栓陳旧度判定の新規指標の確立 (2019)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，山本寛記，國中由美，島田栄美，中須賀諒平，川口真理子，近藤稔和
  • Organizer: 第2回日本法医病理学会・学術全国集会
• [Presentation] 樹状細胞検出による受傷後経過時間判定 (2019)
  • Author(s): 近藤稔和，石田裕子，野坂みずほ，國中由美，島田栄美，中須賀諒平，川口真理子
  • Organizer: 第2回日本法医病理学会・学術全国集会
• [Presentation] Pivotal roles of the CX3CL1-CX3CR1 axis in skin carcinogenesis (2019)
  • Author(s): Ishida Y, Kuninaka Y, Yamamoto Y, Nosaka M, Furukawa F, Mukaida N, Kondo T
  • Organizer: Cytokiens 2019
  • Int'l Joint Research
• [Presentation] Role of intrathrombotic CX3CR1-fractalkine axis during resolution on stasis-induced murine deep vein thrombosis model? (2019)
  • Author(s): Nosaka M, Ishida Y, Kimuda A, Kuninaka Y, Michiue T, Yamamoto H, Mukaida N, Kondo T
  • Organizer: Cytokiens 2019
  • Int'l Joint Research
• [Presentation] 法医解剖例における認知症関連事例の検討 (2019)
  • Author(s): 橋爪佑示子，石田裕子，野坂みずほ，山本寛記，木村章彦，國中由美，島田栄美，川口真理子，近藤稔和
  • Organizer: 第66回日本法医学会学術近畿地方集会
• [Presentation] 頸部が離断された高度焼損死体の一剖検例 (2019)
  • Author(s): 石上安希子，秦 聡，石田裕子，野坂みずほ，國中由美，山本寛記，島田栄美，高安達典，木村章彦，高津光洋，近藤稔和
  • Organizer: 第66回日本法医学会学術近畿地方集会
• [Presentation] 陰毛の白毛発生による年齢推定 (2019)
  • Author(s): 中須賀諒平，木村章彦，石田裕子，野坂みずほ，山本寛記，國中由美，島田栄美，川口真理子，近藤稔和
  • Organizer: 第66回日本法医学会学術近畿地方集会
• [Presentation] 糖尿病マウスにおける慢性創傷はCCL2投与により治癒が促進する (2019)
  • Author(s): 石田裕子，國中由美，野坂みずほ，島田栄美，川口真理子，秋山萬里子，向田直史，近藤稔和
  • Organizer: 第49回日本創傷治癒学会
• [Presentation] Crucial involvement of IL-6 in thrombus resolution in DVT model mouse (2019)
  • Author(s): Nosaka M, Ishida Y, Kimuda A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第48回日本免疫学会学術集会
• [Presentation] Pivotal roles of the CX3CL1-CX3XR1 axis in skin carcinogenesis (2019)
  • Author(s): Ishida Y, Kuninaka Y, Yamamoto Y, Nosaka M, Kimura A, Furukawa F, Mukaida N, Kondo T
  • Organizer: 第48回日本免疫学会学術集会
• [Presentation] Fibrinolytic role of intrathrombotic CX3CR1 and its application to thrombus age estimation in murine deep vein thrombosis model (2019)
  • Author(s): Nosaka M
  • Organizer: The 2st Wakayama Medical University International Symposium of Forensic Molecular Pathology
  • Int'l Joint Research / Invited
• [Presentation] Tne absence of CCL3 exaggerated CaCl2-induced aortic aneurysm (2018)
  • Author(s): Ishida Y, Kondo T, Kuninaka Y, Nosaka M, Kimura A, Yamamoto H, Shimada E, Kawaguchi M
  • Organizer: 24th Congress of the International Academy of Legal Medicine (IALM). The 102nd Congress of the Japanese Society of Legal Medicine
  • Int'l Joint Research
• [Presentation] Forensic pathophysiological study on intrathrombotic aquaporin 1 and 3 for age determination of intravenous thrombi (2018)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Yamamoto H, Kuninaka Y, Shimada E, Hashizume Y, Kondo T
  • Organizer: 24th Congress of the International Academy of Legal Medicine (IALM). The 102nd Congress of the Japanese Society of Legal Medicine
  • Int'l Joint Research
• [Presentation] The influence of circadian rhythm on thrombus formation, infection and intoxication (2018)
  • Author(s): Kuninaka Y, Ishida Y, Nosaka M, Yamamoto H, Shimada E, Kawaguchi M, Kimura A, Kondo T
  • Organizer: 24th Congress of the International Academy of Legal Medicine (IALM). The 102nd Congress of the Japanese Society of Legal Medicine
  • Int'l Joint Research
• [Presentation] Retrospective study on agricultural chemical-related forensic autopsy cases (2018)
  • Author(s): Takayasu T, Yamamoto H, Ishida Y, Nosaka M, Kuninaka Y, Shimada E, Kawaguchi M, Kimura A, Kondo T
  • Organizer: 24th Congress of the International Academy of Legal Medicine (IALM). The 102nd Congress of the Japanese Society of Legal Medicine
  • Int'l Joint Research
• [Presentation] Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by a typical inflammatory chemokine, CCL3 (2018)
  • Author(s): 石田裕子，國中由美，野坂みずほ，木村章彦，向田直史，近藤稔和
  • Organizer: 第39回日本炎症・再生医学会
• [Presentation] 圧負荷による心不全の病態形成におけるSpi-Bの役割解析―プロテオグリカンと炎症性サイトカインの発現制御― (2018)
  • Author(s): 木村章彦，石田裕子，野坂みずほ，佐々木泉，樽谷 玲，山本寛記，國中由美，加藤 喬，福田有里，改正恒康，近藤稔和
  • Organizer: 第39回日本炎症・再生医学会
• [Presentation] 深部静脈血栓塞栓症モデルにおけるCX3CR1の病態生理学的役割の解明 (2018)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，山本寛記，國中由美，向田直史，近藤稔和
  • Organizer: 第39回日本炎症・再生医学会
• [Presentation] 深部静脈血栓塞栓症モデルにおけるCCL5/CCR5の病態生理学的役割の解明 (2018)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，道上知美，山本寛記，國中由美，島田栄美，中山翔平，川口真理子，近藤稔和
  • Organizer: 第１回日本法医病理学会・学術全国集会
• [Presentation] CaCl2誘発大動脈瘤におけるケモカインCCL3の病態生理学的役割 (2018)
  • Author(s): 石田裕子，國中由美，野坂みずほ，道上知美，島田栄美，山本寛記，中山翔平，川口真理子，木村章彦，近藤稔和
  • Organizer: 第１回日本法医病理学会・学術全国集会
• [Presentation] 頸部圧迫による窒息死事例の検討―舌骨・頸部諸軟骨の骨折等について (2018)
  • Author(s): 中山翔平，村上圭秀，秦 聡，道上知美，木村章彦，石田裕子，野坂みずほ，山本寛記，國中由美，島田栄美，川口真理子，近藤稔和
  • Organizer: 第65回日本法医学会学術近畿地方集会
• [Presentation] セルレイン誘発急性膵炎モデルマウスを用いたケモカイン受容体CCR5の病態生理学的役割の解明（第一報） (2018)
  • Author(s): 道上知美，石田裕子，野坂みずほ，木村章彦，島田栄美，國中由美，山本寛記，川口真理子，近藤稔和
  • Organizer: 第65回日本法医学会学術近畿地方集会
• [Presentation] タバコを服用したことによる急性ニコチン中毒の一剖検例 (2018)
  • Author(s): 山本寛記，高安達典，中山翔平，村上圭秀，秦 聡，石田裕子，野坂みずほ，國中由美，島田栄美，道上知美，川口真理子，高津光洋，近藤稔和
  • Organizer: 第65回日本法医学会学術近畿地方集会
• [Presentation] 深部静脈血栓症モデルにおけるCX3CR1-fractalkineの病態生理学的役割の解明 (2018)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，山本寛記，國中由美，近藤稔和
  • Organizer: 第48回日本創傷治癒学会
• [Presentation] Roles of CX3CR1-fractalkine axis during thrombus formation and resolution on murine deep vein thrombosis model (2018)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第47回日本免疫学会学術集会
• [Presentation] CCL2 enhance skin wound healing by promoting macrophage and endothelial progenitor cell accumulation in diabetic mice (2018)
  • Author(s): Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Mukaida N, Kondo T
  • Organizer: 第47回日本免疫学会学術集会
• [Book] WOC Nursing 創傷治癒の最前線 (2018)
  • Author(s): 近藤稔和，石田裕子，野坂みずほ，國中由美
  • Total Pages: 7
  • Publisher: 医学出版
  • ISBN: 9784287730560